Sufentanil-induced Nrf2 protein ameliorates cerebral ischemia-reperfusion injury through suppressing neural ferroptosis
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
279, С. 135109 - 135109
Опубликована: Авг. 27, 2024
Язык: Английский
Bee Pollen Potential to Modulate Ferroptosis: Phytochemical Insights for Age-Related Diseases
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 265 - 265
Опубликована: Фев. 25, 2025
Bee
pollen
(BP)
is
one
of
the
richest
known
natural
resources
micronutrients
and
bioactive
phytochemicals.
Some
captivating
bioactivities
BP
compounds,
although
being
largely
investigated
for
latter
as
individual
molecules,
remain
very
scarcely
or
completely
uninvestigated
in
bee
a
whole
product.
Among
most
intriguing
these
bioactivities,
we
identified
ferroptosis
major
one.
Ferroptosis,
recently
discovered
form
cell
death
(connecting
oxidative
stress
inflammation),
complex
pathophysiological
process
crucial
perplexing
events
current
challenging
human
diseases
such
cancer,
neurodegeneration,
general
aging
diseases.
Many
compounds
were
found
to
intricately
modulate
depending
on
cellular
context
by
inducing
this
mechanism
malignant
cells
preventing
it
non-malignant
cells.
Since
research
both
fields,
i.e.,
ferroptosis,
still
recent,
deemed
necessary
undertake
review
figure
out
extent
potential
modulating
mechanisms.
Our
proved
that
wide
range
(polyphenols,
phenolamides,
carotenoids,
vitamins,
minerals,
others)
substantially
diverse
Accordingly,
phytochemicals
nutrients
showed
interesting
preclinical
studies
lead
ferroptosis-mediated
outcomes
important
processes,
including
many
aging-related
disorders.
One
paramount
challenges
be
resolved
determine
how
different
act
biological
contexts,
either
through
synergistic
antagonistic
behaviors.
We
hope
our
work
constitutes
valuable
incentive
future
investigations
promising
relevant
avenue.
Язык: Английский
Investigation into the Sleep-Promoting Effects of the Traditional Use of Passionflower (Passiflora spp.), Chamomile (Matricaria chamomilla L.) and Mulungu (Erythrina spp.) in Brazil
Drugs and Drug Candidates,
Год журнала:
2025,
Номер
4(1), С. 11 - 11
Опубликована: Март 13, 2025
Background/Objectives:
Sleep
is
essential
to
human
health,
playing
a
vital
role
in
physical
and
mental
well-being.
disorders
can
lead
significant
health
complications,
such
as
cardiovascular
problems,
diabetes,
obesity,
depression.
In
Brazil,
plants
passionflower
(Passiflora
spp.),
chamomile
(Matricaria
chamomilla
L.)
mulungu
(Erythrina
spp.)
are
widely
used
folk
medicine
for
their
sleep-promoting
properties.
This
article
reviews
the
existing
literature
on
effects
of
these
plants,
focusing
Brazilian
context
popular
knowledge
use.
Methods:
An
integrative
review
was
conducted,
including
scientific
articles
English
Portuguese
from
PubMed,
Scielo
Google
Scholar
databases.
Ethnobotanical
studies
documenting
traditional
use
Brazil
clinical
preclinical
research
were
included.
Results:
The
juice
infusion
leaves
fruits
mainly
treat
anxiety
insomnia,
flower
tea
its
sedative
effects,
bark
decoctions
anxiolytic
These
uses
supported
by
demonstrating
efficacy
treating
anxiety,
stress.
Conclusions:
recognition
inclusion
RENISUS
highlights
importance
public
Brazil.
However,
more
rigorous
trials
needed
confirm
safety
ensure
safe
integration
into
modern
medicine.
Язык: Английский
Natural flavonoids from herbs and nutraceuticals as ferroptosis inhibitors in central nervous system diseases: current preclinical evidence and future perspectives
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 24, 2025
Flavonoids
are
a
class
of
important
polyphenolic
compounds,
renowned
for
their
antioxidant
properties.
However,
recent
studies
have
uncovered
an
additional
function
these
natural
flavonoids:
ability
to
inhibit
ferroptosis.
Ferroptosis
is
key
mechanism
driving
cell
death
in
central
nervous
system
(CNS)
diseases,
including
both
acute
injuries
and
chronic
neurodegenerative
disorders,
characterized
by
iron
overload-induced
lipid
peroxidation
dysfunction
the
defense
system.
This
review
discusses
therapeutic
potential
flavonoids
from
herbs
nutraceuticals
as
ferroptosis
inhibitors
CNS
focusing
on
molecular
mechanisms,
summarizing
findings
preclinical
animal
models,
providing
insights
clinical
translation.
We
specifically
highlight
such
Baicalin,
Baicalein,
Chrysin,
Vitexin,
Galangin,
Quercetin,
Isoquercetin,
Eriodictyol,
Proanthocyanidin,
(−)-epigallocatechin-3-gallate,
Dihydromyricetin,
Soybean
Isoflavones,
Calycosin,
Icariside
II,
Safflower
Yellow,
which
shown
promising
results
models
injuries,
ischemic
stroke,
cerebral
ischemia-reperfusion
injury,
intracerebral
hemorrhage,
subarachnoid
traumatic
brain
spinal
cord
injury.
Among
these,
Baicalin
its
precursor
Baicalein
stand
out
due
extensive
research
favorable
outcomes
injury
models.
Mechanistically,
not
only
regulate
Nrf2/ARE
pathway
activate
GPX4/GSH-related
pathways
but
also
modulate
metabolism
proteins,
thereby
alleviating
overload
inhibiting
While
show
promise
especially
settings,
further
needed
evaluate
efficacy,
safety,
pharmacokinetics,
blood-brain
barrier
penetration
application.
Язык: Английский
Copper metabolism in osteoarthritis and its relation to oxidative stress and ferroptosis in chondrocytes
Frontiers in Molecular Biosciences,
Год журнала:
2024,
Номер
11
Опубликована: Сен. 11, 2024
Ferroptosis,
an
iron-ion-dependent
process
of
lipid
peroxidation,
damages
the
plasma
membrane,
leading
to
non-programmed
cell
death.
Osteoarthritis
(OA),
a
prevalent
chronic
degenerative
joint
disease
among
middle-aged
and
older
adults,
is
characterized
by
chondrocyte
damage
or
loss.
Emerging
evidence
indicates
that
ferroptosis
plays
role
in
OA
development.
However,
most
research
has
concentrated
on
regulation
involving
typical
iron
ions,
potentially
neglecting
significance
elevated
copper
ions
both
serum
fluid
patients
with
OA.
This
review
aims
fill
this
gap
systematically
examining
interplay
between
metabolism,
oxidative
stress,
ferroptosis,
copper-associated
death
It
will
provide
comprehensive
overview
ions'
regulating
their
dual
approach
seeks
offer
new
insights
for
further
research,
prevention,
treatment
Язык: Английский
Fighting ferroptosis: Protective effects of dexmedetomidine on vital organ injuries
Life Sciences,
Год журнала:
2024,
Номер
354, С. 122949 - 122949
Опубликована: Авг. 8, 2024
Язык: Английский
Compare and Contrast of the Cellular Actions of Related Flavonoids, Apigenin and Chrysin
Nutrients,
Год журнала:
2024,
Номер
16(23), С. 4195 - 4195
Опубликована: Дек. 4, 2024
In
this
review,
we
provide
an
evidence-based
approach
to
determine
the
cellular
and
systemic
actions
of
two
structurally
similar
flavonoids,
apigenin
chrysin.
We
have
clearly
evaluated
charted
overlapping
diverging
properties
these
sister
flavonoids.
Based
on
separate
Omics-based
approaches
by
our
group
independent
reports
from
others,
cholesterol-lowering
been
revealed.
addition,
prevention
uric
acid
biosynthesis
enhancement
ketogenesis
also
quite
evident
in
Along
with
functions,
chrysin
demonstrated
unique
that
allow
them
stand
out
each
other.
Chrysin
has
abilities
like
downregulating
alanine
metabolism
pyrimidine
synthesis,
which
could
be
helpful
metabolic
diseases
cancer.
contrast,
anti-oxidant
anti-inflammatory
enhancing
endogenous
lipids
upregulating
vasoprotective
metabolites,
beneficial
for
cardiovascular,
renal,
cerebrovascular
complications.
Further
validation
studies
using
vivo
translational
us
better
clarity
regarding
use
agents
therapeutically
treat
a
combination
or
pool
diseases.
Язык: Английский