Development of quercetin-loaded liposomal nanocarriers for alleviation of gemcitabine-induced hepatotoxicity: Optimization, in-vitro, and in-vivo evaluation
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
105, С. 106659 - 106659
Опубликована: Фев. 1, 2025
Язык: Английский
Supramolecular approach to the design of nanocarriers for antidiabetic drugs: targeted patient-friendly therapy
Russian Chemical Reviews,
Год журнала:
2024,
Номер
93(11), С. RCR5150 - RCR5150
Опубликована: Окт. 30, 2024
Diabetes
and
its
complications
derived
are
among
serious
global
health
concerns
that
critically
deteriorate
the
quality
of
life
patients
and,
in
some
cases,
result
lethal
outcome.
Herein,
general
information
on
pathogenesis,
factors
aggravating
course
disease
drugs
used
for
treatment
two
types
diabetes
briefly
discussed.
The
aim
review
is
to
introduce
supramolecular
strategies
currently
being
developed
mellitus
present
a
very
effective
alternative
chemical
synthesis,
allowing
fabrication
nanocontainers
with
switchable
characteristics
meet
criteria
green
chemistry.
Particular
attention
paid
organic
(amphiphilic
polymeric)
formulations,
including
those
natural
origin,
due
their
biocompatibility,
low
toxicity,
bioavailability.
advantages
limitations
different
nanosystems
discussed,
emphasis
adaptivity
noninvasive
administration
routes.<br>The
bibliography
includes
378
references.
Язык: Английский
Targeting Autophagy: A Promising Therapeutic Strategy for Diabetes Mellitus and Diabetic Nephropathy
Diabetes Therapy,
Год журнала:
2024,
Номер
15(10), С. 2153 - 2182
Опубликована: Авг. 21, 2024
Diabetes
mellitus
(DM)
significantly
impairs
patients'
quality
of
life,
primarily
because
its
complications,
which
are
the
leading
cause
mortality
among
individuals
with
disease.
Autophagy
has
emerged
as
a
key
process
closely
associated
DM,
including
complications
such
diabetic
nephropathy
(DN).
DN
is
major
complication
contributing
to
chronic
kidney
disease
and
renal
failure.
The
intricate
connection
between
autophagy
DN,
highlights
potential
for
new
therapeutic
targets.
This
review
examines
interplay
these
conditions,
aiming
uncover
novel
approaches
treatment
enhance
our
understanding
their
underlying
pathophysiology.
It
also
explores
role
in
maintaining
homeostasis
involvement
development
progression
DM
DN.
Furthermore,
discusses
natural
compounds
that
may
alleviate
conditions
by
modulating
autophagy.
Язык: Английский
Berberine hydrochloride-loaded lipid-based nanoparticles ameliorate β-cell function by targeting Nrf2/NF-κB signaling pathway in alloxan-induced diabetes using a murine model: Optimization through full factorial design
Journal of Drug Delivery Science and Technology,
Год журнала:
2024,
Номер
100, С. 106076 - 106076
Опубликована: Авг. 23, 2024
Язык: Английский
SIRT1-Dependent Neuroprotection by Resveratrol in TOCP-Induced Spinal Cord Injury: Modulation of ER Stress and Autophagic Flux
Toxics,
Год журнала:
2024,
Номер
12(11), С. 810 - 810
Опубликована: Ноя. 11, 2024
This
study
explores
the
neuroprotective
effects
of
resveratrol
(Resv)
against
tri-o-cresyl
phosphate
(TOCP)-induced
neurotoxicity
in
spinal
cord
adult
hens.
It
is
well
documented
that
TOCP
exposure
causes
significant
neurodegeneration
via
mechanisms
involve
endoplasmic
reticulum
(ER)
stress
and
impaired
autophagy.
In
this
experiment,
hens
were
assigned
to
one
four
groups:
Control,
Resv,
TOCP,
+
Resv.
The
tissues
examined
through
transmission
electron
microscopy,
hematoxylin
eosin
(HE)
staining,
Nissl
Western
blotting
evaluate
key
proteins
associated
with
ER
Additionally,
RT-qPCR
immunofluorescence
employed
measure
sirtuin1
(SIRT1)
expression.
findings
revealed
induced
severe
ultrastructural
damage,
including
disrupted
myelin
sheaths,
dilated
ER,
extensive
neurodegeneration,
as
confirmed
by
histological
evaluations.
expression
levels
GRP78,
p-PERK,
p-eIF2α,
ATF4,
CHOP,
Beclin-1,
P62,
LC3-II
also
significantly
elevated
TOCP.
However,
Resv
treatment
markedly
attenuated
these
pathological
changes
reducing
stress,
restoring
autophagic
flux,
upregulating
SIRT1
expression,
preserving
integrity.
These
results
indicate
can
effectively
counteract
TOCP-induced
modulating
autophagy,
underscoring
its
potential
a
therapeutic
agent
for
neuroprotection.
Язык: Английский