SIRT1-Dependent Neuroprotection by Resveratrol in TOCP-Induced Spinal Cord Injury: Modulation of ER Stress and Autophagic Flux DOI Creative Commons
Xuebi Tian,

Yiquan Ou,

Shengyuan Shi

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(11), P. 810 - 810

Published: Nov. 11, 2024

This study explores the neuroprotective effects of resveratrol (Resv) against tri-o-cresyl phosphate (TOCP)-induced neurotoxicity in spinal cord adult hens. It is well documented that TOCP exposure causes significant neurodegeneration via mechanisms involve endoplasmic reticulum (ER) stress and impaired autophagy. In this experiment, hens were assigned to one four groups: Control, Resv, TOCP, + Resv. The tissues examined through transmission electron microscopy, hematoxylin eosin (HE) staining, Nissl Western blotting evaluate key proteins associated with ER Additionally, RT-qPCR immunofluorescence employed measure sirtuin1 (SIRT1) expression. findings revealed induced severe ultrastructural damage, including disrupted myelin sheaths, dilated ER, extensive neurodegeneration, as confirmed by histological evaluations. expression levels GRP78, p-PERK, p-eIF2α, ATF4, CHOP, Beclin-1, P62, LC3-II also significantly elevated TOCP. However, Resv treatment markedly attenuated these pathological changes reducing stress, restoring autophagic flux, upregulating SIRT1 expression, preserving integrity. These results indicate can effectively counteract TOCP-induced modulating autophagy, underscoring its potential a therapeutic agent for neuroprotection.

Language: Английский

Development of quercetin-loaded liposomal nanocarriers for alleviation of gemcitabine-induced hepatotoxicity: Optimization, in-vitro, and in-vivo evaluation DOI

Mahran Mohamed Abd El-Emam,

Ahmed Alobaida, Marwa Mohamed El Sayed

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 105, P. 106659 - 106659

Published: Feb. 1, 2025

Language: Английский

Citations

0
Supramolecular approach to the design of nanocarriers for antidiabetic drugs: targeted patient-friendly therapy DOI
Л. А. Васильева, Gulnara A. Gaynanova,

E. A. Romanova

et al.

Russian Chemical Reviews, Journal Year: 2024, Volume and Issue: 93(11), P. RCR5150 - RCR5150

Published: Oct. 30, 2024

Diabetes and its complications derived are among serious global health concerns that critically deteriorate the quality of life patients and, in some cases, result lethal outcome. Herein, general information on pathogenesis, factors aggravating course disease drugs used for treatment two types diabetes briefly discussed. The aim review is to introduce supramolecular strategies currently being developed mellitus present a very effective alternative chemical synthesis, allowing fabrication nanocontainers with switchable characteristics meet criteria green chemistry. Particular attention paid organic (amphiphilic polymeric) formulations, including those natural origin, due their biocompatibility, low toxicity, bioavailability. advantages limitations different nanosystems discussed, emphasis adaptivity noninvasive administration routes.<br>The bibliography includes 378 references.

Language: Английский

Citations

3
Targeting Autophagy: A Promising Therapeutic Strategy for Diabetes Mellitus and Diabetic Nephropathy DOI Creative Commons
Qirui Li,

Huiying Xu,

Rui-Ting Ma

et al.

Diabetes Therapy, Journal Year: 2024, Volume and Issue: 15(10), P. 2153 - 2182

Published: Aug. 21, 2024

Diabetes mellitus (DM) significantly impairs patients' quality of life, primarily because its complications, which are the leading cause mortality among individuals with disease. Autophagy has emerged as a key process closely associated DM, including complications such diabetic nephropathy (DN). DN is major complication contributing to chronic kidney disease and renal failure. The intricate connection between autophagy DN, highlights potential for new therapeutic targets. This review examines interplay these conditions, aiming uncover novel approaches treatment enhance our understanding their underlying pathophysiology. It also explores role in maintaining homeostasis involvement development progression DM DN. Furthermore, discusses natural compounds that may alleviate conditions by modulating autophagy.

Language: Английский

Citations

2
Berberine hydrochloride-loaded lipid-based nanoparticles ameliorate β-cell function by targeting Nrf2/NF-κB signaling pathway in alloxan-induced diabetes using a murine model: Optimization through full factorial design DOI
Mahmoud Mostafa,

Mahran Mohamed Abd El-Emam,

Mohamed Fouad Mansour

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 100, P. 106076 - 106076

Published: Aug. 23, 2024

Language: Английский

Citations

2
SIRT1-Dependent Neuroprotection by Resveratrol in TOCP-Induced Spinal Cord Injury: Modulation of ER Stress and Autophagic Flux DOI Creative Commons
Xuebi Tian,

Yiquan Ou,

Shengyuan Shi

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(11), P. 810 - 810

Published: Nov. 11, 2024

This study explores the neuroprotective effects of resveratrol (Resv) against tri-o-cresyl phosphate (TOCP)-induced neurotoxicity in spinal cord adult hens. It is well documented that TOCP exposure causes significant neurodegeneration via mechanisms involve endoplasmic reticulum (ER) stress and impaired autophagy. In this experiment, hens were assigned to one four groups: Control, Resv, TOCP, + Resv. The tissues examined through transmission electron microscopy, hematoxylin eosin (HE) staining, Nissl Western blotting evaluate key proteins associated with ER Additionally, RT-qPCR immunofluorescence employed measure sirtuin1 (SIRT1) expression. findings revealed induced severe ultrastructural damage, including disrupted myelin sheaths, dilated ER, extensive neurodegeneration, as confirmed by histological evaluations. expression levels GRP78, p-PERK, p-eIF2α, ATF4, CHOP, Beclin-1, P62, LC3-II also significantly elevated TOCP. However, Resv treatment markedly attenuated these pathological changes reducing stress, restoring autophagic flux, upregulating SIRT1 expression, preserving integrity. These results indicate can effectively counteract TOCP-induced modulating autophagy, underscoring its potential a therapeutic agent for neuroprotection.

Language: Английский

Citations

1