Exosome-based cell therapy for diabetic foot ulcers: Present and Prospect
Heliyon,
Год журнала:
2024,
Номер
10(20), С. e39251 - e39251
Опубликована: Окт. 1, 2024
Язык: Английский
Anthracycline-induced cardiotoxicity: emerging mechanisms and therapies
Medicine Plus,
Год журнала:
2025,
Номер
unknown, С. 100074 - 100074
Опубликована: Фев. 1, 2025
Язык: Английский
Comparison of efficacy of exosomes derived from human umbilical cord blood mesenchymal stem cells in treating mouse acute lung injury via different routes
Frontiers in Pediatrics,
Год журнала:
2025,
Номер
13
Опубликована: Май 29, 2025
Objective
To
investigate
the
therapeutic
efficacy
of
human
umbilical
cord
blood
mesenchymal
stem
cell-derived
exosomes
(hUCMSC-Exo)
in
a
lipopolysaccharide
(LPS)-induced
acute
lung
injury
(ALI)
mouse
model
and
compare
effects
different
administration
routes.
Methods
An
ALI
was
established
through
intratracheal
LPS
injection.
Mice
received
hUCMSC-Exo
tail
vein
injection,
nasal
drip,
or
atomization
at
4-and-24
h
post-modeling,
with
comparisons
made
across
low,
medium,
high
doses.
were
categorized
into
three
groups:
control,
model,
experimental
(
n
=
8).
Histopathological
scoring
assessed
inflammation
after
48
h;
inflammatory
cytokine
levels
(TNF-α,
IL-6,
IL-1β,
IL-10)
serum
bronchoalveolar
lavage
fluid
(BALF)
quantified
by
enzyme-linked
immunosorbent
assay
(ELISA).
Results
In
murine
LPS-induced
ALI,
via
intravenous,
intranasal,
nebulized
routes
4
24
post-LPS
exposure
significantly
attenuated
pulmonary
inflammation,
as
evidenced
reduced
alveolar
cell
infiltration,
hemorrhage,
edema
histopathological
analysis
(except
low-dose
group).
ELISA
revealed
that
markedly
decreased
pro-inflammatory
cytokines
TNF-α,
IL-1β
P
<
0.05)
while
increasing
IL-10
levels.
Dose-dependent
observed
routes:
intravenous
high-dose
(Exo-VH)
outperformed
medium-
groups
0.05);
intranasal
medium-dose
(Exo-NM)
superior
to
(Exo-NL;
0.05),
no
significant
difference
between
medium
doses
>
(Exo-AH)
demonstrated
enhanced
over
(Exo-AM;
(Exo-AL;
0.05).
At
an
equivalent
dose
(5
×
10⁸
particles),
delivery
achieved
score
reduction
modulation
compared
whereas
latter
two
showed
comparable
These
findings
collectively
highlight
potential
emerging
optimal
route
tested
dose.
Conclusion
effectively
attenuates
mice.
exhibited
Язык: Английский
The immune regulatory role of exosomal miRNAs and their clinical application potential in heart failure
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Дек. 2, 2024
Heart
failure
(HF)
is
a
complex
and
debilitating
condition
characterized
by
the
heart's
inability
to
pump
blood
effectively,
leading
significant
morbidity
mortality.
The
abnormality
of
immune
response
key
factor
in
progression
HF,
contributing
adverse
cardiac
remodeling
dysfunction.
Exosomal
microRNAs
(miRNAs)
play
pivotal
role
regulating
gene
expression
cellular
function,
which
are
integral
crosstalk
between
cells,
influencing
cell
functions,
such
as
macrophage
polarization,
T
activity,
cytokine
production,
thereby
modulating
various
pathological
processes
inflammation,
fibrosis,
This
review
emphasizes
immune-regulatory
exosomal
miRNAs
HF
highlights
their
clinical
potential
diagnostic
biomarkers
therapeutic
agents.
Язык: Английский