The immune regulatory role of exosomal miRNAs and their clinical application potential in heart failure DOI Creative Commons
Dandan Guo, Jianjun Yan, Zhenyu Yang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 2, 2024

Heart failure (HF) is a complex and debilitating condition characterized by the heart's inability to pump blood effectively, leading significant morbidity mortality. The abnormality of immune response key factor in progression HF, contributing adverse cardiac remodeling dysfunction. Exosomal microRNAs (miRNAs) play pivotal role regulating gene expression cellular function, which are integral crosstalk between cells, influencing cell functions, such as macrophage polarization, T activity, cytokine production, thereby modulating various pathological processes inflammation, fibrosis, This review emphasizes immune-regulatory exosomal miRNAs HF highlights their clinical potential diagnostic biomarkers therapeutic agents.

Language: Английский

Anthracycline-induced cardiotoxicity: emerging mechanisms and therapies DOI Creative Commons
Guanjing Ling, Fei Ge, Weili Li

et al.

Medicine Plus, Journal Year: 2025, Volume and Issue: unknown, P. 100074 - 100074

Published: Feb. 1, 2025

Language: Английский

Citations

0
Exosome-based cell therapy for diabetic foot ulcers: Present and Prospect DOI Creative Commons
Yang Zhou, Meng-Ling Yang, Shunli Rui

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(20), P. e39251 - e39251

Published: Oct. 1, 2024

Language: Английский

Citations

0
The immune regulatory role of exosomal miRNAs and their clinical application potential in heart failure DOI Creative Commons
Dandan Guo, Jianjun Yan, Zhenyu Yang

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Dec. 2, 2024

Heart failure (HF) is a complex and debilitating condition characterized by the heart's inability to pump blood effectively, leading significant morbidity mortality. The abnormality of immune response key factor in progression HF, contributing adverse cardiac remodeling dysfunction. Exosomal microRNAs (miRNAs) play pivotal role regulating gene expression cellular function, which are integral crosstalk between cells, influencing cell functions, such as macrophage polarization, T activity, cytokine production, thereby modulating various pathological processes inflammation, fibrosis, This review emphasizes immune-regulatory exosomal miRNAs HF highlights their clinical potential diagnostic biomarkers therapeutic agents.

Language: Английский

Citations

0