Bacterial-Mediated In Situ Engineering of Tumour-Associated Macrophages for Cancer Immunotherapy
Cancers,
Год журнала:
2025,
Номер
17(5), С. 723 - 723
Опубликована: Фев. 20, 2025
Background/Objectives:
Tumour-associated
macrophages
(TAMs)
are
critical
components
of
the
tumour
microenvironment
(TME),
significantly
influencing
cancer
progression
and
treatment
resistance.
This
review
aims
to
explore
innovative
use
engineered
bacteria
reprogram
TAMs,
enhancing
their
anti-tumour
functions
improving
therapeutic
outcomes.
Methods:
We
conducted
a
systematic
following
predefined
protocol.
Multiple
databases
were
searched
identify
relevant
studies
on
phenotypic
plasticity,
for
reprogramming.
Inclusion
exclusion
criteria
applied
select
studies,
data
extracted
using
standardised
forms.
Data
synthesis
was
performed
summarise
findings,
focusing
mechanisms
benefits
non-pathogenic
modify
TAMs.
Results:
The
summarises
findings
that
can
selectively
target
promoting
shift
from
tumour-promoting
M2
phenotype
tumour-fighting
M1
phenotype.
reprogramming
enhances
pro-inflammatory
responses
activity
within
TME.
Evidence
various
indicates
significant
regression
improved
immune
bacterial
therapy.
Conclusions:
Reprogramming
TAMs
presents
promising
strategy
approach
leverages
natural
targeting
abilities
directly
tumour,
potentially
patient
outcomes
offering
new
insights
into
immune-based
treatments.
Further
research
is
needed
optimise
these
methods
assess
clinical
applicability.
Язык: Английский
Unveiling the microbial influence: bacteria’s dual role in tumor metastasis
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Март 14, 2025
As
cancer
research
advances,
the
intricate
relationship
between
microbiome
and
is
gaining
heightened
recognition,
especially
concerning
tumor
metastasis,
where
bacterial
involvement
becomes
increasingly
complex.
This
review
seeks
to
systematically
examine
dual
roles
of
bacteria
in
metastasis
process,
encompassing
both
mechanisms
that
facilitate
inhibitory
effects
exerted
by
specific
microorganisms.
We
explore
through
which
influence
cell
migration
inducing
chronic
inflammation,
evading
host
immune
responses,
remodeling
ECM.
Moreover,
immunomodulatory
potential
probiotics
genetically
engineered
offers
promising
prospects
for
prevention
treatment
metastasis.
article
elucidates
complexity
emerging
frontiers
examining
clinical
significance
as
biomarkers
evaluating
antibiotic
usage
on
metastatic
process.
posit
comprehending
biological
characteristics
bacteria,
a
critical
component
microenvironment,
will
offer
innovative
strategies
theoretical
foundations
treatment.
Furthermore,
this
explores
future
directions,
including
application
technologies
bacteria-based
therapeutic
strategies,
thereby
offering
valuable
perspective
development
novel
anti-cancer
approaches.
Язык: Английский
Organoids with a Type 1 Collagen Scaffold to Model Bacterial Cancer Therapy
Cells,
Год журнала:
2025,
Номер
14(7), С. 524 - 524
Опубликована: Апрель 1, 2025
Bacterial
cancer
therapy
(BCT)
is
emerging
as
an
important
option
for
the
treatment
of
solid
tumours,
with
promising
outcomes
in
preclinical
trials.
Further
progress
hampered
by
incomplete
understanding
how
oncotropic
bacteria,
such
attenuated
strains
Salmonella
enterica
serovar
Typhimurium,
colonise
tumours
and
responses
both
bacteria
tumour
cells
to
this
colonisation.
To
model
this,
we
developed
organoids
that
are
permissive
bacterial
colonisation,
replacing
conventional
commercially
available
extracellular
matrix
(e.g.,
Matrigel)
a
type
I
collagen
scaffold.
A
comparison
two
matrices
indicated
1
permitted
initial
infection
efficiency
more
than
5-times
greater
Matrigel.
In
addition,
subsequent
growth
within
expanded
cell
numbers
over
10-fold
4
days
infection.
These
allow
visualisation
chemoattraction,
invasion
population
interior
lumen,
will
permit
future
optimisation
BCT.
establishing
patient-derived
organoids,
demonstrate
platform
developing
personalised
treatments
exploiting
Язык: Английский
Salmonella-Derived Fluorescent Carbon Dots for Reprogramming Tumor-Associated Macrophages and Enhancing Tumor Photodynamic Therapy
ACS Applied Bio Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 24, 2025
Carbon
dots
(CDs)
are
used
as
photosensitizers
for
the
photodynamic
therapy
of
tumors
while
retaining
specific
functional
groups
and
biochemical
properties
carbon
precursors.
However,
short-wavelength
excitation
limits
their
application
in
tumors.
Upconversion
nanoparticles
(UCNPs)
effectively
solve
problem
low
penetration
due
to
by
converting
low-energy
near-infrared
light
into
high-energy
ultraviolet
or
visible
light.
In
this
paper,
were
prepared
a
hydrothermal
method
using
Salmonella
alendronic
acid
raw
materials,
phosphate
on
surface
coordinated
with
upconversion
form
UCNP@CD
nanoprobes.
Under
irradiation
an
808
nm
laser,
emitted
from
can
further
catalyze
enhance
generation
reactive
oxygen
species
killing
tumor
cells.
Meanwhile,
reprogrammed
M2
macrophages
M1
improve
immunosuppressive
microenvironment.
The
nanoprobes
tumor-associated
macrophage
reprogramming
tumors,
which
provides
effective
strategy
multimodal
synergistic
treatment.
Язык: Английский