International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(23), С. 12752 - 12752
Опубликована: Ноя. 27, 2024
Extracellular
vesicles
(EVs)
play
important
roles
in
intercellular
communication
various
biological
events.
In
particular,
EVs
released
from
cancer
cells
have
attracted
special
attention.
Although
it
has
been
reported
that
cancer-associated
glycosphingolipids
the
enhancement
of
malignant
properties
cells,
presence,
behavior,
and
not
elucidated.
Recently,
we
crucial
expressing
gangliosides,
GD2,
and/or
GD3
melanomas
gliomas.
However,
how
containing
their
to
date.
Here,
studied
spatio-temporal
mechanisms
for
GD3/GD2-containing
gliomas
actions
toward
target
cells.
Proteome
analyses
with/without
GD3/GD2
revealed
an
equally
high
concentration
integrin
isoforms
both
GD3/GD2+
GD3/GD2-
EVs.
PKH26-labeled
attached,
invaded,
distributed
to/in
within
1
h.
formed
molecular
complexes
with
integrins
on
as
elucidated
by
immunoprecipitation/immunoblotting
immunocytostaining.
The
addition
antibodies
reactive
GD3,
or
resulted
suppression
enhancing
effects
cell
adhesion
assay.
+
clearly
increased
phosphorylation
levels
PDGF
receptor,
FAK,
Erk1/2
immunoblotting,
suggesting
activate
signaling
pathway
15
min
after
addition.
Anti-ganglioside
blocked
conclusion,
GD3/GD2-expressing
glioma
enhance
phenotypes
signals
via
cluster
formation
EVs,
leading
regulation
microenvironment.
European journal of medical research,
Год журнала:
2024,
Номер
29(1)
Опубликована: Янв. 12, 2024
Abstract
Glial
fibrillary
acidic
protein
(GFAP),
an
intracellular
type
III
intermediate
filament
protein,
provides
structural
support
and
maintains
the
mechanical
integrity
of
astrocytes.
It
is
predominantly
found
in
astrocytes
which
are
most
abundant
subtypes
glial
cells
brain
spinal
cord.
As
a
marker
astrocytes,
GFAP
may
exert
variety
physiological
effects
neurological
diseases.
For
example,
previous
published
literatures
showed
that
autoimmune
astrocytopathy
inflammatory
disease
central
nervous
system
(CNS).
Moreover,
studies
tumors
mainly
focus
on
predictive
value
tumor
volume.
Furthermore,
using
biomarkers
early
setting
will
lead
to
simplified
standardized
way
estimate
poor
outcome
traumatic
injury
(TBI)
ischemic
stroke.
Recently,
observational
revealed
cerebrospinal
fluid
(CSF)
GFAP,
as
valuable
potential
diagnostic
biomarker
for
neurosyphilis,
had
sensitivity
76.60%
specificity
85.56%.
The
reason
plasma
could
serve
promising
diagnosis
prediction
Alzheimer's
(AD)
it
effectively
distinguished
AD
dementia
from
multiple
neurodegenerative
diseases
predicted
individual
risk
progression.
In
addition,
can
be
helpful
differentiating
relapsing–remitting
sclerosis
(RRMS)
versus
progressive
MS
(PMS).
This
review
article
aims
provide
overview
clinical
progression
neuroinflammation,
tumors,
TBI,
stroke,
genetic
disorders,
neurodegeneration
other
CNS
explore
therapeutic
methods.
CNS Neuroscience & Therapeutics,
Год журнала:
2024,
Номер
30(5)
Опубликована: Май 1, 2024
Abstract
Gliomas
are
the
most
common
primary
tumors
of
central
nervous
system,
with
glioblastoma
multiforme
(GBM)
having
highest
incidence,
and
their
therapeutic
efficacy
depends
primarily
on
extent
surgical
resection
postoperative
chemotherapy.
The
role
intracranial
blood–brain
barrier
occurrence
drug‐resistant
gene
O6‐methylguanine‐DNA
methyltransferase
have
greatly
limited
chemotherapeutic
agents
in
patients
GBM
made
it
difficult
to
achieve
expected
clinical
response.
In
recent
years,
rapid
development
nanotechnology
has
brought
new
hope
for
treatment
tumors.
Nanoparticles
(NPs)
shown
great
potential
tumor
therapy
due
unique
properties
such
as
light,
heat,
electromagnetic
effects,
passive
targeting.
Furthermore,
NPs
can
effectively
load
drugs,
significantly
reduce
side
effects
improve
efficacy,
showing
chemotherapy
glioma.
this
article,
we
reviewed
mechanisms
glioma
drug
resistance,
physicochemical
NPs,
advances
resistance.
We
aimed
provide
perspectives
Cancers,
Год журнала:
2023,
Номер
15(15), С. 3804 - 3804
Опубликована: Июль 26, 2023
Glioblastoma
(GBM)
is
a
highly
aggressive
and
lethal
primary
brain
cancer
that
necessitates
early
detection
accurate
diagnosis
for
effective
treatment
improved
patient
outcomes.
Traditional
diagnostic
methods,
such
as
imaging
techniques
tissue
biopsies,
have
limitations
in
providing
real-time
information
distinguishing
treatment-related
changes
from
tumor
progression.
Liquid
used
to
analyze
biomarkers
body
fluids,
offer
non-invasive
dynamic
approach
detecting
monitoring
GBM.
This
article
provides
an
overview
of
GBM
including
circulating
cells
(CTCs),
cell-free
DNA
(cfDNA),
RNA
(cfRNA),
microRNA
(miRNA),
extracellular
vesicles.
It
explores
the
clinical
utility
these
detection,
monitoring,
prognosis.
Challenges
implementing
liquid
biopsy
strategies
practice
are
also
discussed.
The
highlights
potential
biopsies
valuable
tools
personalized
management
but
underscores
need
standardized
protocols
further
research
optimize
their
utility.
Nanoscale,
Год журнала:
2023,
Номер
15(26), С. 10904 - 10938
Опубликована: Янв. 1, 2023
This
review
summarizes
recent
advances
in
extracellular
vesicle-based
carriers
for
glioblastoma
diagnosis
and
therapy,
points
out
the
current
challenges
perspectives.
Seminars in Cancer Biology,
Год журнала:
2024,
Номер
101, С. 25 - 43
Опубликована: Май 14, 2024
Glioblastoma
(GBM)
is
the
most
aggressive
tumor
among
gliomas
and
intracranial
tumors
to
date
prognosis
for
GBM
patients
remains
poor,
with
a
median
survival
typically
measured
in
months
few
years
depending
on
various
factors.
Although
standardized
therapies
are
routinely
employed,
it
clear
that
these
strategies
unable
cope
heterogeneity
invasiveness
of
GBM.
Furthermore,
diagnosis
monitoring
responses
directly
dependent
tissue
biopsies
or
magnetic
resonance
imaging
(MRI)
techniques.
From
this
point
view,
liquid
arising
as
key
sources
variety
biomarkers
advantage
being
easily
accessible
monitorable.
In
context,
extracellular
vesicles
(EVs),
physiologically
shed
into
body
fluids
by
virtually
all
cells,
gaining
increasing
interest
both
natural
carriers
specific
signatures
even
What
makes
particularly
attractive
they
also
emerging
therapeutical
vehicles
treat
given
their
native
ability
cross
blood-brain
barrier
(BBB).
Here,
we
reviewed
recent
advances
use
EVs
biomarker
biopsy
nanocarriers
targeted
delivery
anticancer
drugs
glioblastoma.
Exosomes,
which
are
small
extracellular
vehicles
produced
by
a
variety
of
cell
types,
have
emerged
as
key
actors
in
intercellular
communication
due
to
their
ability
transport
diverse
payload
proteins,
nucleic
acids,
and
lipids.
This
is
critical
both
normal
pathological
situations,
particularly
the
complicated
terrain
brain
illnesses.
book
chapter
introduces
exosomes
many
actions
inside
central
nervous
system
(CNS).
These
duties
include
crucial
activities
like
cell-to-cell
communication,
waste
disposal,
inflammation
regulation,
neuroprotection.
Exosomes
been
connected
neurological
disorders
such
Alzheimer's
Parkinson's
disease,
where
they
replicate
misfolded
proteins
contribute
disease
progression.
Furthermore,
related
cancer,
promote
tumor
formation
dissemination.
Understanding
concepts
behind
exosome-mediated
diseases
enables
diagnostic
innovation
therapy
progress.
provide
promising
approach
for
biomarker
creation,
with
potential
change
early
detection
monitoring.
targeted
utilization
drug
delivery
brings
up
new
therapeutic
options.
review
focuses
on
roles
CNS
consequences
understanding,
diagnosing,
even
treating
Pathology & Oncology Research,
Год журнала:
2024,
Номер
30
Опубликована: Фев. 6, 2024
Glioblastoma
is
the
most
aggressive
brain
tumor
with
extremely
poor
prognosis
in
adults.
Routine
treatments
include
surgery,
chemotherapy,
and
radiotherapy;
however,
these
may
lead
to
rapid
relapse
development
of
therapy-resistant
tumor.
cells
are
known
communicate
macrophages,
microglia,
endothelial
cells,
astrocytes,
immune
microenvironment
(TME)
promote
preservation.
It
was
recently
demonstrated
that
Glioblastoma-derived
extracellular
vesicles
(EVs)
participate
bidirectional
intercellular
communication
TME.
Apart
from
promoting
glioblastoma
cell
proliferation,
migration,
angiogenesis,
EVs
their
cargos
(primarily
proteins
miRNAs)
can
act
as
biomarkers
for
diagnosis
prognosis.
Furthermore,
they
be
used
therapeutic
tools.
In
this
review,
mechanisms
Glioblastoma-EVs
biogenesis
TME
have
been
summarized.
Moreover,
there
discussion
surrounding
novel
diagnostic
structures
tools
glioblastoma.
Finally,
unclear
questions
require
future
investigation
reviewed.
Current Issues in Molecular Biology,
Год журнала:
2024,
Номер
46(7), С. 6903 - 6939
Опубликована: Июль 3, 2024
Accounting
for
48%
of
malignant
brain
tumors
in
adults,
glioblastoma
has
been
great
interest
the
last
decades,
especially
biomolecular
and
neurosurgical
fields,
due
to
its
incurable
nature
notable
neurological
morbidity.
The
major
advancements
technologies
have
positively
influenced
extent
safe
tumoral
resection,
while
latest
progress
field
GBM
uncovered
new
potential
therapeutical
targets.
Although
currently
no
curative
therapy,
recent
made
management
this
disease,
both
from
surgical
molecular
perspectives.
main
current
therapeutic
approach
is
multimodal
consists
intervention,
radiotherapy,
chemotherapy,
mostly
with
temozolomide.
most
patients
will
develop
treatment
resistance
tumor
recurrence
after
removal,
regarding
contributed
a
better
understanding
pathology
management.
Over
past
few
specific
biomarkers
discovered
that
helped
predict
prognosis
responses
improvements
survival
rates.
