Meditsinskiy sovet = Medical Council,
Год журнала:
2024,
Номер
5, С. 222 - 228
Опубликована: Май 11, 2024
Smooth
skin
mycoses
are
common
all
over
the
world
and
occur
in
20-30%
of
population.
Currently,
with
climate
change,
distribution
areas
pathogenic
fungi
changing,
which
is
observed
world.
In
this
paper,
analysis
changes
epidemiological
regions
spread
feet
hands,
microsporia,
trichophytia
onychomycosis
Russia
carried
out.
The
most
disadvantaged
federal
districts
have
been
identified.
incidence
as
well
onychomycosis,
increased
Northwestern,
Central,
Ural
Far
Eastern
districts.
At
same
time,
infections
District
localized
mainly
Khabarovsk
Territory,
but
not
Yamalo-Nenets
District.
Microsporia
Volga
North
Caucasian
Siberian,
and,
especially,
Caucasus
(10
times
higher
than
national
average)
recent
years,
microsporia
has
significantly
decreased
Southern
moment,
prosperous
terms
epidemiology
types
superficial
mycoses.
district,
it
necessary
to
find
out
cause
highly
trichophytia.
First
all,
may
be
due
aquaphilic
pathogens.
article
provides
recommendations
for
treatment
prevention
smooth
skin.
main
drug
sertaconazole.
hydrophobic
nature
makes
possible
obtain
effective
topical
products
based
on
(creams,
gels,
shampoos,
candles).
Several
sertaconazole-based
drugs
developed
Russia,
example,
Acrimicol
cream,
recommended
multicolored
lichen.
Genes,
Год журнала:
2025,
Номер
16(2), С. 146 - 146
Опубликована: Янв. 24, 2025
Background/Objectives:
Dermatophytosis,
a
prevalent
fungal
infection
of
keratinized
tissues,
is
primarily
caused
by
the
filamentous
fungus
Trichophyton
rubrum.
Sertraline
(SRT),
an
antidepressant
with
antifungal
activity,
has
already
demonstrated
therapeutic
potential
against
this
fungus.
Elucidating
effects
SRT
may
provide
insights
into
its
mechanism
action
and
adaptation
to
drug.
Differential
gene
expression
alternative
splicing
(AS)
facilitate
adaptations
various
environmental
conditions.
This
study
aimed
comprehensive
overview
AS
events
their
implications
in
T.
rubrum
cultivated
under
sub-inhibitory
concentrations
SRT.
Method:
The
transcriptome
challenged
was
analyzed
detect
events.
Results:
RNA-seq
analysis
revealed
that
affected
transcriptional
post-transcriptional
numerous
genes,
including
those
encoding
transcription
factors,
kinases,
efflux
pumps.
Among
events,
intron
retention
predominant.
After
12
h
exposure,
intron-3
levels
serine/arginine
protein
kinase
mRNA
transcripts
were
significantly
increased
compared
control.
new
isoform
would
produce
putative
partially
lost
phosphotransferase
domain.
Conclusions:
These
findings
highlight
mechanisms
suggest
how
adapts
itself
Pediatric Blood & Cancer,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 6, 2025
Invasive
fungal
diseases
(IFD)
in
children
with
newly
diagnosed
acute
lymphoblastic
leukemia
(ALL)
and
lymphoma
(LBL)
are
poorly
characterized,
especially
lower-middle-income
countries
(LMICs).
This
study
aims
to
identify
the
incidence,
risk
factors,
outcomes
of
IFD
a
pediatric
cohort
ALL/LBL.
We
retrospectively
analyzed
patients
ALL/LBL
between
January
December
2023
at
tertiary
cancer
center
India.
Patients
were
risk-stratified
treated
per
modified
ICiCLe-ALL-14
protocol.
IFDs
classified
as
proven,
probable,
possible
according
revised
EORTC/MSG
consensus
definition.
Among
407
patients,
392(96%)
had
ALL.
The
overall
incidence
was
25%,
probable/proven
infections
12%.
Mold
predominated
(79
cases,
77%),
followed
by
yeast
(21
21%).
In
comparison
without
IFDs,
those
more
likely
have
received
dexamethasone
(30
vs.
20%;
p
=
0.009),
anthracycline
(28
14%;
0.001)
during
induction
central
venous
access
(27
18%;
0.008).
6-week
mortality
rate
15%,
rising
26%
cases.
Coexisting
bacterial
infection
associated
increased
(odds
ratio:
19.2[95%CI:
3.5-105];
0.001).
common
LMICs,
particularly
early
phases
therapy.
These
considerable
mortality,
often
compounded
concomitant
sepsis.
Given
these
findings,
consideration
antifungal
prophylaxis
is
warranted
mitigate
morbidity
due
IFDs.
