Bioengineering, Год журнала: 2024, Номер 12(1), С. 6 - 6
Опубликована: Дек. 25, 2024
Glaucoma, a progressive and multifactorial optic neurodegenerative disease, still poses significant challenges in both diagnosis management remains perpetual enigma [...].
Язык: Английский
Heliyon, Год журнала: 2024, Номер 10(15), С. e35516 - e35516
Опубликована: Авг. 1, 2024
Glaucoma, a leading cause of irreversible blindness worldwide, is characterized by progressive loss retinal ganglion cells (RGCs) and optic nerve damage. While elevated intraocular pressure (IOP) the only known modifiable risk factor, normal-tension glaucoma (NTG) challenges this notion, suggesting other mechanisms beyond IOP may contribute to its development. Emerging evidence support hypothesis that be an autoimmune disease. This review summarizes for hypothesis, focusing on gut-retina axis. We discuss how antigens gut bacterial prime peripheral T breach blood-retina barrier (BRB) initiate cross-reactivity with ocular tissues via molecular mimicry, resulting in RGC Understanding these uncover new diagnostic biomarkers therapeutic strategies targeting immune pathways alongside conventional IOP-lowering treatments.
Язык: Английский
Процитировано
1
Ophthalmology Science, Год журнала: 2024, Номер 5(1), С. 100610 - 100610
Опубликована: Авг. 28, 2024
Язык: Английский
Процитировано
1
Frontiers in Bioscience-Landmark, Год журнала: 2024, Номер 29(8)
Опубликована: Авг. 23, 2024
This review explores the connection between ocular surface microbiome and glaucoma, highlighting its impact on disease progression. Beginning with an overview of global glaucoma significance, it emphasizes importance understanding cellular characteristics microbiology microbiome. A search was conducted PubMed Cochrane Library databases using phrase "ocular glaucoma". 0 records were returned from while 21 PubMed. total results retrieved 2017 to 2024. comprised one opinion paper, four original research articles, 16 reviews. covered anatomy surface, advanced analysis methods, It also delved into dysbiosis in addressing altered microbial communities their potential role The intricate interplay host's immune system is explored, emphasizing crosstalk inflammatory responses. concludes by discussing therapeutic implications, including modulating microbiota future treatment strategies. Understanding healthy glaucomatous eyes can help researchers clinicians innovative approaches health.
Язык: Английский
Процитировано
1
Clinical and Experimental Ophthalmology, Год журнала: 2024, Номер unknown
Опубликована: Сен. 26, 2024
Abstract Background Glaucoma is the most common cause of irreversible blindness, and gut microbiota (GM) associated with glaucoma. Whether this association represents a causal role remains unknown. This study aims to assess potential link between GM various forms glaucoma, emphasising need for cautious interpretation strength these associations. Methods Employing two‐sample bidirectional Mendelian randomisation (MR) framework false discovery rate correction sensitivity analyses, supplemented by genetic correlation analysis via linkage disequilibrium score regression (LDSC) colocalisation European summary‐level data MiBioGen consortium FinnGen Study, we sought explore relationship Results While certain microbial taxa showed associations glaucoma subtypes (e.g., Erysipelotrichaceae primary angle closure Senegalimassilia exfoliation glaucoma), overall findings suggest complex not definitively Notably, reverse MR did establish significant effect on composition, no consistent correlations were observed Conclusions our provides some evidence specific results underscore complexity relationships further research clarify links. The highlight importance interpreting gut‐eye axis caution that while may play in it unlikely be predominant factor.
Язык: Английский
Процитировано
1
Elsevier eBooks, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Язык: Английский
Процитировано
0
Russian Ophthalmological Journal, Год журнала: 2024, Номер 17(2), С. 148 - 153
Опубликована: Июль 2, 2024
Nowadays, glaucoma is viewed as a multifactorial neurodegenerative condition that involves many factors affecting different cell types in human body. As known, increased intraocular pressure (IOP) not the only threatening factor of ganglion apoptosis and glaucomatous optic neuropathy development; IOP can be associated with other factors, such vascular, metabolic, neurotrophic, immune, inflammatory, etc. However, treatment remains largely symptomatic, aimed almost exclusively at reducing IOP. Microbiotic dysbiosis newly developing research direction progress, showing this mechanism may turn out to an important development. There are reasons believe strategies microbiota damage correction contribute better efficiency management.
Язык: Английский
Процитировано
0
Cureus, Год журнала: 2024, Номер unknown
Опубликована: Авг. 13, 2024
The gut microbiome has been studied in recent years due to its association with various pathological pathways involved different diseases, caused by structure, function, and diversity alteration. knowledge of this mechanism generated interest the investigation relationship ophthalmologic diseases. Recent studies infer existence a gut-eye microbiota axis, influenced intestinal barrier, blood-retina immune privilege eye. A common denominator among diseases that have related axis is inflammation, which perpetuated dysbiosis, causing an alteration barrier leading increased permeability and, turn, release components such as lipopolysaccharides (LPS), trimethylamine oxide (TMAO), bacterial translocation. Some theories explain depending on how composed, type T cells will be activated, while others say some bacteria can pre-activate mimic ocular structures allow leakage metabolites into circulation. In addition, therapies probiotics, diet, fecal transplantation (FMT) shown favor presence balanced population microorganisms limit inflammation generate beneficial effect these eye pathologies. This review aims analyze influences pathologies based microbial composition mechanisms, may provide better understanding their therapeutic potential.
Язык: Английский
Процитировано
0
Current Research in Microbial Sciences, Год журнала: 2024, Номер 7, С. 100314 - 100314
Опубликована: Янв. 1, 2024
Glaucoma is the primary cause of irreversible blindness globally. Different glaucoma subtypes are identified by their underlying mechanisms, and treatment options differ its pathogenesis. Current management includes topical medications to lower intraocular pressure surgical procedures like trabeculoplasty drainage implants. Fecal microbiota transplantation (FMT) an almost effective safe option for recurrent Clostridium difficile infection. The relationship between bacterial populations, metabolites, inflammatory pathways in retinal diseases indicates possible therapeutic strategies. Thus, incorporating host microbiota-based therapies could offer additional patients. Here, we propose that combining FMT with standard treatments may benefit those affected this condition. Also, potential safety, efficacy, cost-effectiveness clinical applications discussed.
Язык: Английский
Процитировано
0
Bioengineering, Год журнала: 2024, Номер 12(1), С. 6 - 6
Опубликована: Дек. 25, 2024
Glaucoma, a progressive and multifactorial optic neurodegenerative disease, still poses significant challenges in both diagnosis management remains perpetual enigma [...].
Язык: Английский
Процитировано
0