Dubai Medical Journal,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 8, 2024
Introduction:
Amyotrophic
lateral
sclerosis
(ALS),
a
neurodegenerative
disease
that
causes
muscle
weakness,
paralysis,
and
death,
develops
when
motor
neurons
begin
to
die.
There
are
few
proven
treatments
for
ALS,
because
the
is
incurable,
exact
cause
unknown,
making
it
devastating
condition.
According
recent
research,
marine
algae
may
contain
bioactive
substances
can
be
used
treat
ALS.
Methods:
The
comprehensive
review
of
publications
focused
on
compounds
extracted
from
various
species
algae,
including
their
mechanisms
action
against
oxidative
stress,
neuroinflammation,
apoptosis
in
were
reviewed
scientific
journals
(ScienceDirect,
Springer,
Taylor
&
Francis,
MDPI)
indexed
several
databases
(Scopus,
Web
Science,
PubMed,
Google
Scholar,
so
on).
Discussion:
Compounds
derived
polyunsaturated
fatty
acids,
fucoxanthin,
polysaccharides,
exhibit
potential
neuroprotective
effects
by
modulating
neuroinflammation
stress
levels.
Fucoxanthin,
fucosterol,
alginate
demonstrated
mitigating
damage
inflammation,
which
critical
factors
pathogenesis
Conclusion:
Bioactive
obtained
demonstrate
considerable
as
therapeutic
agents
owing
capacity
influence
multiple
pathways
linked
neuroinflammation.
Further
investigation
required
comprehend
medicinal
value,
well
develop
novel
alternative
The Veterinary Journal,
Год журнала:
2025,
Номер
unknown, С. 106358 - 106358
Опубликована: Апрель 1, 2025
Antimicrobial
resistance
is
a
growing
global
concern,
prompting
for
antibiotic
alternatives
in
animal
production.
Seaweed,
abundant
bioactive
compounds
with
anti-inflammatory
properties,
offers
natural
substitute
to
synthetic
compounds.
Considering
this,
the
objective
of
present
study
was
evaluate
bioactivity
three
seaweeds
1:1
combination
Ascophyllum
nodosum,
Palmaria
palmata,
and
Ulva
lactuca.
Initially,
polyphenol,
flavonoid,
total
phlorotannin
content
seaweed
species
were
assessed
through
colorimetric
assays.
Subsequently,
first
evaluated
an
inhibition
protein
precipitation
assay
then
confirmed
vitro
gene
expression
assays
LPS-stimulated
porcine
alveolar
macrophages
(PAMs).
The
evaluation
molecules
revealed
high
TPC
(1487.67±40.39
1763.57±69.01mg
TAE/100mg
sample,
respectively),
as
well
TFC
(95.68±3.62
126.09±7.34mg
CE/100mg
sample)
TPhC
(0.167±0.02
0.23±0.01mg
PGE/100mg)
AN
UL,
respectively.
inhibiting
disclosed
that
extracts
combining
two
algae
(ANUL,
ANPP,
PPUL)
more
effective
than
effect
exhibited
by
each
single
extract.
assessment
significant
down-regulation
IL-1β
TNF-α
extracts.
In
contrast,
TGF-β
showed
increasing
trend.
These
findings,
along
confirmation
molecules,
highlight
algae's
potential,
making
them
suitable
antibiotics
disease
prevention
livestock
sector.
Therefore,
future
research
should
explore
specific
validate
their
efficacy
vivo
confirm
potential
use
UTTAR PRADESH JOURNAL OF ZOOLOGY,
Год журнала:
2024,
Номер
45(13), С. 170 - 188
Опубликована: Июнь 10, 2024
The
growing
problem
of
antibiotic
resistance
calls
for
a
paradigm
shift
in
medication
discovery.
Fortunately,
the
enormous
oceans,
home
to
an
incredible
diversity
life,
provide
viable
solution:
marine
metabolites.
These
unusual
chemicals
have
potential
treating
wide
range
diseases.
This
present
study
investigates
great
using
these
marine-derived
gems
disease
management
techniques.
Despite
difficulty
procuring
and
isolating
organisms,
discovering
most
effective
metabolites,
traversing
lengthy
research
pipelines,
rewards
are
apparent.
To
demonstrate
power
resources,
paper
examines
successful
case
studies.
Each
delves
deeply
into
single
metabolite,
including
its
source
organism,
it
targets,
precise
mechanism
by
which
metabolite
disrupts
process.
We'll
look
at
results
clinical
trials
that
examined
efficacy
safety
medications,
eventually
exposing
real-world
influence
on
patient
outcomes
after
incorporating
them
treatment
plans.
Examining
cases
provides
useful
insights
resources
producing
novel
opening
path
further
discovery
innovation
battle
against
Marine Drugs,
Год журнала:
2024,
Номер
22(10), С. 478 - 478
Опубликована: Окт. 19, 2024
Macroalgae
are
known
as
abundant
sources
of
phytochemicals,
which
offer
a
plethora
beneficial
biological
properties.
Besides
being
the
most
notable
classes
compounds
found
in
macroalgae,
phlorotannins,
bromophenols,
and
terpenoids
comprise
some
relevant
for
their
Phlorotannins,
mainly
prevalent
brown
algae
structurally
characterized
complex
polyphenolic
derived
from
phloroglucinol
units,
possess
robust
antioxidant,
anti-inflammatory,
antitumor,
cytotoxic
activities,
modulated
by
factors
such
degree
polymerization
environmental
conditions.
Bromophenols,
halogenated
other
marine
organisms,
exhibit
significant
antioxidant
antiviral
Their
diverse
structures
bromination
patterns
contribute
to
potential
therapeutic
chemical
defense
agents.
Pigments
(chemically
described
primary
terpenoids)
play
critical
role
light
absorption
energy
transfer
macroalgae
divided
into
three
main
groups:
(i)
carotenoids,
primarily
provide
photoprotective
benefits;
(ii)
chlorophylls,
facilitating
conversion
energy;
(iii)
phycobilins,
mostly
red
important
roles
transfer,
besides
providing
remarkable
health
benefits.
Finally,
secondary
terpenoids,
particularly
(e.g.,
Rhodomelaceae
family)
central
cellular
interactions
antimicrobial,
antidiabetic,
anti-inflammatory
This
study
represents
detailed
analysis
biosynthesis,
structural
diversity,
activities
these
metabolites,
emphasizing
Science & Technology Indonesia,
Год журнала:
2024,
Номер
9(2), С. 502 - 516
Опубликована: Апрель 2, 2024
The
increasing
demand
for
effective
and
natural
anti-inflammatory
agents
prompts
an
investigation
into
the
properties
of
Sonneratia
caseolaris
(L.)
Engl.,
a
plant
traditionally
used
in
medicine.
This
study
aimed
to
explore
ability
S.
leaves
extract
inhibit
inflammation
accelerate
wound
healing.
were
collected
from
Tanjung
Api-Api
area,
Banyuasin,
South
Sumatra.
method
involved
carrageenan
induction
rat
paws
as
inflammatory
model.
results
showed
that
most
dose
was
found
group
with
150
mg/kg
BW
measured
using
digital
caliper
plethysmometer.
qualitative
phytochemical
test
contain
alkaloids,
steroids,
flavonoids,
phenols.
GC-MS
analysis
thought
aldehydes,
glucosinolates,
coumarins,
esters,
terpenoids,
alcohols,
lipids,
tocopherols,
steroids.
Due
their
diverse
range
mechanisms
action,
coumarins
show
significant
promise
mitigating
hold
potential
treating
conditions.
provides
new
insights
related
source
agents,
supporting
public
comprehension
regarding
utilization
traditional
herbal
remedies.
Journal of King Saud University - Science,
Год журнала:
2024,
Номер
36(8), С. 103342 - 103342
Опубликована: Июль 8, 2024
The
purpose
of
the
study
was
to
assess
a
phenolic
compound
that
extracted
from
brown
seaweed
Enteromorpha
intestinalis
(Linn.),
Nees
(1820)
for
its
antibacterial
activities
on
different
bacterial
pathogens
fish
illnesses.
Hexane
and
methanol
were
utilized
extract
bioactive
compounds
seaweed.
Phytochemical
analysis
methnaolic
extracts
have
revealed
presence
carbohydrates
glycosides,
saponins,
alkaloids,
amino
acids,
flavonoids,
fixed
oil
fat,
phenol
compounds,
tannins,
steroids.
fish,
including
Providencia
vermicola,
Aeromonas
hydrophila,
Vibrio
harveyi,
caviae,
targeted
assessment.
Among
them,
methanolic
crude
fraction-1
E.
shown
maximum
activity
against
A.
hydrophila
(22
±
0.13
33
0.56
µg/mL).
Column
chromatography
employed
isolate
effective
fraction,
while
FT-IR
HPLC
characterization.
phytochemical
confirmed
various
in
both
extracts.
demonstrated
efficacy
beside
tested
pathogens.
functional
groups
associated
with
polymeric
structures
extracts,
alcohols,
phenols,
aromatics,
alkyl
halides,
aliphatic
amines,
alkynes,
alkenes.
Overall,
exhibited
significant
as
result
chemicals
are
present.
provides
valuable
baseline
data,
emphasizing
need
further
research
towards
developing
drug
formulations.
Food Science & Nutrition,
Год журнала:
2024,
Номер
12(12), С. 10255 - 10261
Опубликована: Ноя. 4, 2024
ABSTRACT
Cystitis
glandularis
(CG),
known
as
a
pre‐gradual
lesion
in
the
bladder,
is
pathological
changes
vesical
mucosa
characterized
by
inflammatory
invasion
and
chronic
obstruction.
Clinically,
effective
treatment
against
CG
prescribed
only
when
using
drug
therapy.
Fucoidan,
naturally
extractive
polysaccharide,
well‐reported
bioactive
compound
with
anti‐inflammatory
immunoregulatory
properties.
In
this
research,
an
emerging
computational
approach
was
applied
to
explicate
anti‐CG
actions
pharmacological
targets
exhibited
fucoidan
detail.
Current
network
pharmacology
data
showed
that
16
intersection
genes
of
were
identified,
whereas
all
6
core
targets,
including
interleukin‐6
(IL‐6),
tumor
necrosis
factor
(TNF),
interleukin‐1B
(IL‐1B),
matrix
metalloproteinase‐9
(MMP‐9),
interleukin‐10
(IL‐10),
metalloproteinase‐2
(MMP‐2),
biological
processes,
signaling
pathways
characterized,
respectively.
As
revealed
underlying
mechanism,
achieved
chiefly
implicated
reduction
reactions
enhancement
immunoregulation.
Taken
together,
these
bioinformatics
findings
may
be
used
reveal
effects
mechanism
before
further
experimental
validation.
Furthermore,
those
identified
therapeutic
for
research
development
fucoidan‐anti‐CG.
Inflammation
is
part
of
the
host’s
normal
response
to
various
harmful
stimuli,
including
chemical
exposure,
tissue
damage,
infection,
or
contact
with
bacterial
components,
such
as
lipopolysaccharide
(LPS);
however,
excessive
inflammation
leads
acute
and
chronic
human
diseases.
Macrophages
contribute
inflammatory
process
by
secreting
mediators,
prostaglandin
E2
(PGE2)
nitric
oxide
(NO),
well
proinflammatory
cytokines
IL-1[Formula:
see
text],
TNF-[Formula:
text]
IL-6
excess
these
mediators
can
be
tissues
organisms.
The
RAW
264.7
murine
macrophage
cell
line
treated
LPS
a
commonly
used
in
vitro
model
for
assessing
anti-inflammatory
efficacy.
base
conventional
therapy
use
steroidal
nonsteroidal
medications,
both
which
have
significant
adverse
effects.
Therefore,
finding
new
sources
less
hazardous
treatments
imperative.
qualities
bioactive
lipids
from
crude
extracts
green
alga
Cladophora
were
investigated
using
ethanol
hexane-ether
two
distinct
solvents.
As
result,
total
lipid
concentration
extraction
was
higher,
so
unsaturated
fatty
acids
(UFAs)
extracted
this
sample
methanol-solvent
crystallization
technique
at
low
temperatures.
presence
their
percentage
purity
determined
gas
chromatography
(GC).
After
elimination
49.11%
saturated
acids,
spontaneous
nanoemulsification
approach
applied
improve
stability
functionalization
acids.
nanoemulsion
particles’
size,
distribution,
evaluated
Zetasizer
system.
mean
particle
size
zeta
potential
value
194.3
nm
−25.8
mV,
respectively.
Finally,
MTT
(thiazolyl
blue
tetrazolium
bromide)
assay
determine
toxicity
RAW264.7
24
h,
results
showed
an
increase
viability
cells
UFAs
after
encapsulation.
IC[Formula:
values
calculated
each
formulation
effects
(at
1/3
value)
LPS-stimulated
macrophages
performing
(NO)
cytokine
enzyme-linked
immunosorbent
assays.
Nanoemulsions
polyunsaturated
inhibited
production
NO
interleukin
6,
may
promising
candidates
biological
medical
applications
combat
inflammation.
Advances in medical technologies and clinical practice book series,
Год журнала:
2024,
Номер
unknown, С. 265 - 304
Опубликована: Сен. 25, 2024
Autoimmune
diseases
and
inflammatory
conditions
pose
significant
challenges
to
public
health
globally,
necessitating
the
exploration
of
novel
therapeutic
avenues.
In
recent
years,
marine
organisms
have
emerged
as
promising
sources
bioactive
compounds
with
diverse
pharmacological
properties.
Marine
metabolites,
derived
from
various
such
algae,
sponges,
corals,
microorganisms,
exhibit
remarkable
structural
diversity
biological
activities,
making
them
attractive
candidates
for
drug
discovery
development.
Here
discuss
mechanisms
action
underlying
immunomodulatory
anti-inflammatory
effects
marine-derived
compounds,
including
inhibition
pro-inflammatory
cytokines,
modulation
immune
cell
function,
regulation
signalling
pathways
implicated
in
autoimmunity
inflammation.
Furthermore,
highlight
specific
metabolites
that
shown
preclinical
clinical
outcomes
treatment
autoimmune
diseases,
rheumatoid
arthritis
etc.
