Modern Developments in the Application and Function of Metal/Metal Oxide Nanocomposite–Based Antibacterial Agents

BioNanoScience, Год журнала: 2023, Номер 13(2), С. 840 - 852

Опубликована: Апрель 15, 2023

Язык: Английский

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Combretastatin A4-based coumarins: synthesis, anticancer, oxidative stress-relieving, anti-inflammatory, biosafety, and in silico analysis

Chemical Papers, Год журнала: 2024, Номер 78(6), С. 3705 - 3720

Опубликована: Фев. 18, 2024

Язык: Английский

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6,7-Coumarin-heterocyclic hybrids: A comprehensive review of their natural sources, synthetic approaches, and bioactivity

Journal of Molecular Structure, Год журнала: 2024, Номер 1303, С. 137601 - 137601

Опубликована: Янв. 22, 2024

Язык: Английский

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Biocompatible chlorocoumarins from harmful chlorophenols, their synthesis and biomedicinal evaluation

Journal of Molecular Structure, Год журнала: 2024, Номер 1309, С. 138193 - 138193

Опубликована: Март 30, 2024

Язык: Английский

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Application of DFT Calculations in Designing Polymer-Based Drug Delivery Systems: An Overview

Pharmaceutics, Год журнала: 2022, Номер 14(9), С. 1972 - 1972

Опубликована: Сен. 19, 2022

Drug delivery systems transfer medications to target locations throughout the body. These are often made up of biodegradable and bioabsorbable polymers acting as components. The introduction density functional theory (DFT) has tremendously aided application computational material science in design development drug materials. use DFT other approaches avoids time-consuming empirical processes. Therefore, this review explored how computation may be utilized explain some features polymer-based systems. First, we went through key aspects provided context. Then looked at essential characteristics a system that simulations could predict. We observed Gaussian software had been extensively employed by researchers, particularly with B3LYP 6-31G(d, p) basic sets for However, give researchers choice basis set modelling complicated organic systems, such polymer–drug complexes, then offered possible resources presented future trend.

Язык: Английский

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Transition Metal-Decorated B₁₂N₁₂–X (X = Au, Cu, Ni, Os, Pt, and Zn) Nanoclusters as Biosensors for Carboplatin

ACS Omega, Год журнала: 2023, Номер 8(11), С. 10006 - 10021

Опубликована: Март 7, 2023

Theoretical studies on the adsorption, sensibility, and reactivity of a boron nitride nanocage decorated with Au, Cu, Ni, Os, Pt, Zn metals as biosensor material were carried out for adsorption carboplatin by applying density functional theory computation at B3LYP-GD3BJ/def2svp level theory. All optimized structures, well calculations regards studied objective including electronic properties, geometry optimization parameters, energy studies, natural bond orbital analysis, topology sensor mechanistic thermodynamic properties (ΔG ΔH), investigated herein. As result, noticeable change in gap surfaces when interacting accounted surfaces' reactivity, stability, conductivity, work function, overall ability, implying that are good materials sensing carboplatin. Furthermore, negative energies obtained suggest surface has superior ability to sense chemisorption was seen. Substantially, geometric short length after thermodynamically spontaneous reactions, acceptable mechanism results demonstrate have strong characteristics

Язык: Английский

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Nanoparticle-based materials in anticancer drug delivery: Current and future prospects

Heliyon, Год журнала: 2023, Номер 9(11), С. e21227 - e21227

Опубликована: Окт. 20, 2023

The past decade has witnessed a breakthrough in novel strategies to treat cancer. One of the most common cancer treatment modalities is chemotherapy which involves administering anti-cancer drugs body. However, these can lead undesirable side effects on healthy cells. To overcome this challenge and improve cell targeting, many nanocarriers have been developed deliver directly cancerous cells minimize tissues. majority research studies conclude that, using encapsulated much safer more effective alternative than delivering drug alone its free form. This review provides summary types mainly studied for delivery, namely: liposomes, polymeric micelles, dendrimers, magnetic nanoparticles, mesoporous gold carbon nanotubes quantum dots. In review, synthesis, applications, advantages, disadvantages, previous nanomaterials are discussed detail. Furthermore, future opportunities possible challenges translating materials into clinical applications also reported.

Язык: Английский

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Coumarins derived from natural methoxystilbene as oxidative stress-related disease alleviators: Synthesis and in vitro-in silico study

Journal of Molecular Structure, Год журнала: 2023, Номер 1302, С. 137471 - 137471

Опубликована: Дек. 31, 2023

Язык: Английский

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Novel coumarins from green sweet bell pepper seeds: Their isolation, characterization, oxidative stress-mitigating, anticancer, anti-inflammatory, and antidiabetic properties

Journal of Molecular Structure, Год журнала: 2024, Номер 1312, С. 138629 - 138629

Опубликована: Май 16, 2024

Язык: Английский

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Plant‐Derived Coumarins: A Narrative Review of Their Structural and Biomedical Diversity

Chemistry & Biodiversity, Год журнала: 2024, Номер 21(6)

Опубликована: Апрель 8, 2024

Plant-derived coumarin (PDC) is a naturally occurring heterocyclic backbone that belongs to the benzopyrone family. PDC and its based products are characterized by low toxicity high distribution in variety of herbal treatments have numerous therapeutic potentials. These include anticoagulants, antibacterials, anti-inflammatory agents, anticancer antioxidants, others. So, it may be appropriate investigate qualities potential bioactivities PDCs. This article provides an overview biomedical potentials, availability, clinical use possibilities PDCs, with focus on their important modes action, using information various pharmacological discovered. The data used this study came from published research between 2015 2023. We reviewed selection databases, including PubMed, Scopus, Web Science, Google Scholar, during period. In conclusion, because abundance medicinal plants, biochemistry attributes PDCs currently interest. medical specialties, serve useful role as agents.

Язык: Английский

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