Synergistic Effects of Radical Distributions of Soluble and Insoluble Polymers within Electrospun Nanofibers for an Extending Release of Ferulic Acid
Ran Dong,
Wenjian Gong,
Qiuyun Guo
и другие.
Polymers,
Год журнала:
2024,
Номер
16(18), С. 2614 - 2614
Опубликована: Сен. 15, 2024
Polymeric
composites
for
manipulating
the
sustained
release
of
an
encapsulated
active
ingredient
are
highly
sought
after
many
practical
applications;
particularly,
water-insoluble
polymers
and
core–shell
structures
frequently
explored
to
manipulate
behaviors
drug
molecules
over
extended
time
period.
In
this
study,
electrospun
nanostructures
were
utilized
develop
a
brand-new
strategy
tailor
spatial
distributions
both
insoluble
polymer
(ethylcellulose,
EC)
soluble
(polyvinylpyrrolidone,
PVP)
within
nanofibers,
thereby
extended-release
loaded
ingredient,
ferulic
acid
(FA).
Scanning
electron
microscopy
transmission
assessments
revealed
that
all
prepared
nanofibers
had
linear
morphology
without
beads
or
spindles,
those
from
coaxial
processes
obvious
structure.
X-ray
diffraction
attenuated
total
reflectance
Fourier
transform
infrared
spectroscopic
tests
confirmed
FA
fine
compatibility
with
EC
PVP,
presented
in
amorphous
state.
vitro
dissolution
indicated
radical
(decreasing
shell
core)
PVP
(increasing
able
play
their
important
role
elaborately.
On
one
hand,
F3
advantages
homogeneous
composite
F1
higher
content
solutions
inhibit
initial
burst
provide
longer
period
release.
other
F2
core
negative
tailing-off
The
key
element
was
water
permeation
rates,
controlled
by
ratios
polymers.
new
based
on
structure
paves
way
developing
wide
variety
polymeric
heterogeneous
realizing
desired
functional
performances.
Язык: Английский
Targeted therapeutic strategy for oral squamous carcinoma using celecoxib-loaded GABA/wheat gluten-alginate nanocarrier hydrogel with glutathione down-regulation and enhanced CCND2-mediated apoptosis
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 140679 - 140679
Опубликована: Фев. 1, 2025
Язык: Английский
Radiation-induced nanogel engineering based on pectin for pH-responsive rutin delivery for cancer treatment
Naunyn-Schmiedeberg s Archives of Pharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 14, 2024
This
research
investigates
the
formulation
of
a
nanogel
complex
using
pectin
and
poly(acrylic
acid)
(PAAc)
to
encapsulate
rutin.
The
nanogel's
pH-responsive
behavior
its
potential
as
targeted
drug
delivery
platform
are
investigated.
gamma
irradiation-induced
crosslinking
mechanism
is
elucidated,
highlighting
role
in
creating
stable
three-dimensional
network
structure
within
polymer
matrix.
Fourier
transform
infrared
spectroscopy
analysis
sheds
light
on
molecular
interactions
rutin
nanogel-rutin
complex.
explored,
showcasing
ability
release
selectively
response
pH
variations
displaying
high
physical
chemical
stability.
Transmission
electron
microscopy
imaging
provides
visual
insights
into
morphology
interactions.
cumulative
content
from
was
86.14
±
2.61%.
pH-dependent
profile
examined,
demonstrating
selective
varying
levels.
Cytotoxicity
studies
were
conducted
against
four
human
cancer
cell
lines-HepG2,
A549,
MCF-7,
HCT-116
showing
significant
reductions
IC
Язык: Английский
Interpenetrating Polymer Networks in Biomedical Fields: Recent Advanced and Applications
Polymers for Advanced Technologies,
Год журнала:
2025,
Номер
36(2)
Опубликована: Фев. 1, 2025
ABSTRACT
Recent
developments
in
polymer
materials
have
led
to
an
increased
implementation
of
hydrogels
biomedical
settings,
especially
the
creation
smart
hydrogels.
Traditional
single‐network
often
exhibit
challenges,
such
as
poor
mechanical
strength,
insufficient
biocompatibility,
and
slow
response
rates.
To
address
these
issues,
researchers
introduced
Interpenetrating
Polymer
Network
(IPN)
hydrogels,
which
significantly
improve
strength
via
topological
entanglements
physical
interactions.
This
dual‐network
design
not
only
enhances
biocompatibility
but
also
responsiveness
stimuli,
endowing
with
distinctive
properties
like
cell
adhesion,
conductivity,
hemostatic
functions,
antioxidant
abilities,
color‐changing
properties.
The
purpose
this
article
is
elucidate
factors
that
trigger
stimuli
IPN
their
impacts
on
cellular
behavior,
various
applications
they
can
serve.
A
comprehensive
overview
provided
regarding
classification,
mechanisms,
performance
attributes,
related
subjects.
Ultimately,
review
emphasizes
promise
hold
fulfilling
increasing
need
for
innovative
improved
features
sector.
Язык: Английский
LC-MS/MS Profiling and Immunomodulatory Potential of Green-Synthesized Zinc Oxide Nanoparticles Using Cordia sebestena Leaves Against Chromium-Induced Acute Lung Injury in Rats.
Journal of Drug Delivery Science and Technology,
Год журнала:
2025,
Номер
unknown, С. 106750 - 106750
Опубликована: Фев. 1, 2025
Язык: Английский
Design, nanogel synthesis, anti-proliferative activity and in silico ADMET profile of pyrazoles and pyrimidines as topo-II inhibitors and DNA intercalators
RSC Advances,
Год журнала:
2025,
Номер
15(13), С. 10037 - 10048
Опубликована: Янв. 1, 2025
Pyrazole
derivatives
2
and
3,
pyrimidine
derivative
4,
their
nanogels
as
drug
delivery
systems
were
synthesized,
cytotoxicity
against
MCF-7,
HCT-116,
HepG2
A549
cells
was
evaluated.
Язык: Английский
Targeting cell signaling pathway ALKBH5/Beclin1/ULK1 in lung cancer by 5-flurouracil- loaded P (AAm/SA) nanogel in rats
APOPTOSIS,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 1, 2025
Язык: Английский
Synthesis and characterization of sodium alginate/poly(N-vinylpyrrolidone) nano-carrier loaded with rebaudioside A and/or stevioside for anticancer drug delivery
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
316, С. 144778 - 144778
Опубликована: Май 29, 2025
Язык: Английский
Nano-carrier for [1,2,4]triazolo[4,3-a]quinoxaline derivatives as inhibitors of Topo-II and intercalators for DNA: Design, synthesis, in silico docking, ADMET and anti-proliferative evaluations
Journal of Molecular Structure,
Год журнала:
2025,
Номер
unknown, С. 142850 - 142850
Опубликована: Июнь 1, 2025
Язык: Английский
Dual Temperature and pH Sensitive Poly(ethyl methacrylate‐co‐acrylamide) Nanogels Have Potential for Controlled Release of Doxorubicin
ChemistrySelect,
Год журнала:
2024,
Номер
9(37)
Опубликована: Сен. 30, 2024
Abstract
In
this
study,
the
synthesis
and
characterization
of
poly(ethyl
methacrylate‐
co
‐acrylamide)
(i.e.,
poly(EMA‐
‐AAm))
nanogels
loading
release
studies
doxorubicin
hydrochloride
were
carried
out.
The
was
out
using
emulsion
polymerization
technique
at
60
°C.
Swelling
experiments
showed
that
sensitive
to
temperature
pH
medium.
Zeta
sizer
analysis
results
synthesized
had
an
average
size
23.17
nm
PDI
value
0.270.
into
nanogels,
drug
capacity
(DLC)
nanogel
determined
as
32%
efficiency
(DLE)
77%.
Release
conducted
=
5.4
7.4
37
°C
percentage
17%
even
in
32
h
7.4,
82%
5
5.4.
different
temperatures
revealed
°C,
85%
39
89%
41
These
‐AAm)
can
be
used
targeted
controlled
increase
effects
while
reducing
side
effects.
Язык: Английский