International Journal of Pharmaceutics,
Год журнала:
2023,
Номер
648, С. 123561 - 123561
Опубликована: Окт. 30, 2023
3D
Printing
(3DP)
of
pharmaceuticals
could
drastically
transform
the
manufacturing
medicines
and
facilitate
widespread
availability
personalised
healthcare.
However,
with
increasing
awareness
environmental
damage
manufacturing,
3DP
must
be
eco-friendly,
especially
when
it
comes
to
carbon
emissions.
This
study
investigated
effects
pharmaceutical
3DP.
Using
Design
Experiments
(DoE)
Machine
Learning
(ML),
we
looked
at
energy
use
in
Fused
Deposition
Modeling
(FDM).
From
136
experimental
runs
across
four
common
dosage
forms,
identified
several
key
parameters
that
contributed
consumption,
consequently
CO
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
17(2), С. 2791 - 2813
Опубликована: Янв. 6, 2025
Transplantation
of
bone
implants
is
currently
recognized
as
one
the
most
effective
means
treating
defects.
Biobased
and
biodegradable
polyester
composites
combine
good
mechanical
degradable
properties
polyester,
thereby
providing
an
alternative
for
implant
materials.
Bone
tissue
engineering
(BTE)
accelerates
defect
repair
by
simulating
microenvironment.
Composite
scaffolds
support
formation
further
accelerate
process
repair.
The
introduction
3D
printing
technology
enables
preparation
to
be
more
precise,
reproducible,
flexible,
which
a
very
promising
development.
This
review
presents
physical
BTE
summarizes
strategies
adopted
domestic
international
scholars
improve
based
on
biobased
polyester/ceramic
in
recent
years.
In
addition,
future
development
prospects
field
challenges
expanding
production
clinical
applications
are
presented.
Materials & Design,
Год журнала:
2024,
Номер
238, С. 112679 - 112679
Опубликована: Янв. 17, 2024
A
three-stage
solid
state
synthesis
assisted
by
thermodynamic
modelling
was
developed
to
prepare
highly
pure
(>99
%)
beta
tricalcium
phosphate
(β-TCP)
powder.
The
optimal
temperature
experimentally
determined
be
1000
°C
in
good
agreement
with
the
theoretical
calculations.
design
described
here
has
substantially
improved
product
quality
and
eliminated
presence
of
secondary
phases
compared
one-
two-stage
methods
investigated
this
work.
comprehensive
characterization
material's
structural,
vibrational,
morphological
characteristics
conducted.
Rietveld
refinement
X-ray
diffraction
data
confirmed
high
purity
samples.
crystal
structure
prepared
β-TCP
refined
unit
cell
parameters
agreed
well
reference
values.
From
infrared
Raman
spectral
analyses,
were
observed
discussed
details.
Furthermore,
morphology
elemental
composition
products
examined
found
homogenous
impurity
free.
reproducibility
material
scrutinized
showed
no
significant
variations.
Using
our
method,
it
is
possible
produce
powder
consistent
repeatability.
Ceramics International,
Год журнала:
2024,
Номер
50(15), С. 27403 - 27415
Опубликована: Май 4, 2024
In
response
to
the
urgent
demand
for
innovative
bone
regeneration
solutions,
focus
of
this
study
is
develop
and
characterize
Mg,
Sr,
Zn-substituted
calcium
phosphate
scaffolds
that
replicate
trabecular
architecture
cancellous
bone.
Ion
substitution
represents
a
promising
approach
improve
biological
effectiveness
phosphates
composite
materials
used
in
tissue
engineering
applications.
Porous
mimicking
natural
structure
were
additively
manufactured
from
photosensitive
ceramic
suspensions
vat
photopolymerization
using
digital
light
processing.
The
impact
selected
trace
elements
(0,
1
5
mol.%
substitution)
sintering
temperature
(900,
1000,
1100,
1200,
1300
°C)
was
investigated
relation
obtained
crystalline
phase
content,
microstructure,
elemental
distribution,
thermal
stability,
mechanical
properties.
After
sintering,
addition
hydroxyapatite,
β-tricalcium
detected
as
result
added
calcium-deficient
hydroxyapatite
starting
powder.
exhibited
uniform
distribution
elements,
they
feature
3D-designed
porosity
predominantly
ranged
10
900
μm
diameter,
with
an
average
pore
size
546.25
±
10.95
μm.
total
76.24
1.32
vol.%
wall
thickness
217.03
8.98
μm,
closely
resembling
morphology
tissue.
properties
sintered
at
1100°C,
1200°C,
1300°C
line
those
typically
observed
demonstrates
feasibility
custom
made
bioactive
powders
together
design
on
demand,
based
requirements
individual
defects.
ACS Omega,
Год журнала:
2024,
Номер
9(27), С. 29186 - 29204
Опубликована: Июнь 28, 2024
3D
printing
is
a
promising
technique
for
producing
bone
implants,
but
there
still
need
to
adjust
efficiency,
facilitate
production,
and
improve
biocompatibility.
Porous
materials
have
proven
positive
effect
on
the
regeneration
of
tissue,
their
production
associated
with
numerous
limitations.
In
this
work,
we
described
simple
method
polymer
or
polymer-ceramic
filaments
3D-printing
scaffolds
by
adding
micrometer-scale
porous
structures
scaffold
surfaces.
Scaffolds
included
polycaprolactone
(PCL)
as
primary
polymer,
β-tricalcium
phosphate
(β-TCP)
ceramic
filler,
poly(ethylene
glycol)
(PEG)
porogen.
The
pressurized
filament
extrusion
gave
flexible
composed
PCL,
β-TCP,
PEG,
which
are
ready
use
in
fused
fabrication
(FFF)
printers.
Washing
3D-printed
ethanol
solution
removed
PEG
revealed
microporous
structure
particles
scaffold's
Furthermore,
exhibit
good
precision,
no
cytotoxic
properties,
highly
impact
MG63
cell
alignment.
Although
combining
β-TCP
quite
popular,
presented
allows
well-organized
without
advanced
equipment,
produced
can
be
used
print
commercially
available
printer.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Ноя. 5, 2024
Orthopedic
implants
have
faced
challenges
in
treating
bone
defects
due
to
various
factors,
including
inadequate
osseointegration,
oxidative
stress,
bacterial
infection,
immunological
rejection,
and
poor
individualized
treatment.
These
profoundly
affect
both
the
results
of
treatment
patients'
daily
lives.
There
is
great
promise
for
layer-by-layer
(LbL)
assembly
method
tissue
engineering.
The
primarily
relies
on
electrostatic
attraction
entails
consecutive
deposition
electrolyte
complexes
with
opposite
charges
onto
a
substrate,
leading
formation
homogeneous
single
layers
that
can
be
quickly
deposited
produce
nanolayer
films.
LbL
has
attracted
considerable
interest
as
coating
technology
because
its
ease
production,
cost-effectiveness,
capability
apply
diverse
biomaterial
coatings
without
compromising
primary
bio-functional
properties
substrate
materials.
This
review
will
look
into
fundamentals
evolution
orthopedics,
provide
an
analysis
chemical
strategy
used
prepare
introduce
application
orthopedics
over
recent
years.
Among
many
potential
uses
LbL,
such
implementation
sustained-release
programmed
drug
delivery,
which
turn
promotes
osseointegration
development
new
blood
vessels,
well
antibacterial,
antioxidant,
other
similar
applications.
In
addition,
we
offer
thorough
examination
cell
behavior
interaction
facilitate
advancement
next-generation
films
Advanced Healthcare Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 10, 2025
Abstract
Effective
treatment
of
bone
diseases
is
quite
tricky
due
to
the
unique
nature
tissue
and
complexity
repair
process.
In
combination
with
biological
materials,
cells
factors
can
provide
a
highly
effective
safe
strategy
for
regeneration,
especially
based
on
these
multifunctional
hydrogel
interface
materials.
However,
itis
still
challenge
formulate
materials
fascinating
properties
(e.g.,
activity,
controllable
biodegradability,
mechanical
strength,
excellent
cell/tissue
adhesion,
release
properties)
their
clinical
applications
in
complex
processes.
this
review,
we
will
highlight
recent
advances
developing
functional
hydrogels.
We
then
discuss
barriers
producing
without
sacrificing
inherent
properties,
potential
cartilage
are
discussed.
Multifunctional
serve
as
fundamental
building
block
engineering.
Advanced Engineering Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 13, 2025
This
review
aims
to
summarize
recent
advances
in
3D
printing
technologies
for
polymer‐based
bone
scaffolds,
focusing
on
material
applications
and
clinical
implications.
The
applicable
different
materials
are
discussed
with
their
characteristics
application
advantages,
specifically
the
common
techniques
polymer
used.
Recent
of
3D‐printed
scaffolds
multifunctionality
(i.e.,
drug
delivery,
regeneration
minimally
invasive
implantation)
then
presented
provide
guidance
potential
applications.
