Anti-inflammatory Effect of Pyrus calleryana var. fauriei on Dextran Sulfate Sodium-induced Acute Colitis in Mice and Lipopolysaccharide-treated RAW 264.7 cells DOI
Mi-Ra Lee, Bohye Kim, Hee‐Jun Kim

и другие.

Korean Journal of Medicinal Crop Science, Год журнала: 2024, Номер 32(6), С. 393 - 401

Опубликована: Дек. 31, 2024

Back ground: Inflammatory bowel disease (IBD) is a pathological condition of the gastrointestinal tract characterized by chronic and relapsing inflammation. This study investigated anti-inflammatory effects Pyrus calleryana var. fauriei extract (PCE) in vitro vivo.BR/Methods Results: Lipopolysaccharide (LPS)-treated RAW 264.7 cells dextran sulfate sodium (DSS)-induced colitis mice were used to evaluate PCE. In cells, PCE inhibited nitric oxide production phagocytosis without cytotoxicity, pro-inflammatory cytokines tumor necrosis factor-α interleukin (IL)-6. Colitis was induced using 2% DSS for 5 days, administered 14 days. treatment relieved symptoms colitis, such as weight loss, diarrhea, bloody feces. Moreover, ameliorated splenomegaly colonic shortening, indicators colitis. reduced levels inflammatory cytokines, IL-6 IL-22. Histological analysis revealed that alleviated mucosal damage macrophage infiltration.BR/Conclusions: These results suggest has activity on LPS-treated ameliorates clinical DSS-induced mice. Therefore, potential therapeutic candidate IBD.

Язык: Английский

Inflammation-Targeted Delivery of Probiotics for Alleviation of Colitis and Associated Cognitive Disorders through Improved Vitality and Colonization DOI
Yi Chen,

Mingju Shui,

Hongyi Li

и другие.

Biomaterials, Год журнала: 2025, Номер 318, С. 123163 - 123163

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1

Rosmarinic acid-chondroitin sulfate nanoconjugate for targeted treatment of ulcerative colitis DOI

Miaomiao Long,

Jie Li,

Meiyang Yang

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 141008 - 141008

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1

Recent advances in dietary polyphenols (DPs): antioxidant activities, nutrient interactions, delivery systems, and potential applications DOI
Yalin Ran, Fuhua Li, Zhigang Xu

и другие.

Food & Function, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

The antioxidant capacity of DPs is determined by internal chemical structures and environmental factors. Green delivery systems help improve their bioactivities bioavailability, providing great options for personalized food nutrition.

Язык: Английский

Процитировано

4

Berberine‑calcium alginate-coated macrophage membrane-derived nanovesicles for the oral treatment of ulcerative colitis DOI
Huilin Ma, Y. Li, Huan Shi

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 294, С. 139114 - 139114

Опубликована: Янв. 2, 2025

Язык: Английский

Процитировано

0

Egg white-derived peptides co-assembly-reinforced zein/chondroitin sulfate nanoparticles for orally colon-targeted co-delivery of quercetin in colitis mitigation DOI

Sitong Ma,

Jingbo Liu, Yajuan Li

и другие.

Food Bioscience, Год журнала: 2025, Номер unknown, С. 106161 - 106161

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0

Efficacy of chondroitin sulfate as an emerging biomaterial for cancer-targeted drug delivery: A short review DOI
Sekar Vijayakumar, Zaira Isabel González-Sánchez, Mani Divya

и другие.

International Journal of Biological Macromolecules, Год журнала: 2024, Номер 283, С. 137704 - 137704

Опубликована: Ноя. 15, 2024

Язык: Английский

Процитировано

1

Anti-inflammatory Effect of Pyrus calleryana var. fauriei on Dextran Sulfate Sodium-induced Acute Colitis in Mice and Lipopolysaccharide-treated RAW 264.7 cells DOI
Mi-Ra Lee, Bohye Kim, Hee‐Jun Kim

и другие.

Korean Journal of Medicinal Crop Science, Год журнала: 2024, Номер 32(6), С. 393 - 401

Опубликована: Дек. 31, 2024

Back ground: Inflammatory bowel disease (IBD) is a pathological condition of the gastrointestinal tract characterized by chronic and relapsing inflammation. This study investigated anti-inflammatory effects Pyrus calleryana var. fauriei extract (PCE) in vitro vivo.BR/Methods Results: Lipopolysaccharide (LPS)-treated RAW 264.7 cells dextran sulfate sodium (DSS)-induced colitis mice were used to evaluate PCE. In cells, PCE inhibited nitric oxide production phagocytosis without cytotoxicity, pro-inflammatory cytokines tumor necrosis factor-α interleukin (IL)-6. Colitis was induced using 2% DSS for 5 days, administered 14 days. treatment relieved symptoms colitis, such as weight loss, diarrhea, bloody feces. Moreover, ameliorated splenomegaly colonic shortening, indicators colitis. reduced levels inflammatory cytokines, IL-6 IL-22. Histological analysis revealed that alleviated mucosal damage macrophage infiltration.BR/Conclusions: These results suggest has activity on LPS-treated ameliorates clinical DSS-induced mice. Therefore, potential therapeutic candidate IBD.

Язык: Английский

Процитировано

0