Anti-inflammatory Effect of Pyrus calleryana var. fauriei on Dextran Sulfate Sodium-induced Acute Colitis in Mice and Lipopolysaccharide-treated RAW 264.7 cells DOI
Mi-Ra Lee, Bohye Kim, Hee‐Jun Kim

et al.

Korean Journal of Medicinal Crop Science, Journal Year: 2024, Volume and Issue: 32(6), P. 393 - 401

Published: Dec. 31, 2024

Back ground: Inflammatory bowel disease (IBD) is a pathological condition of the gastrointestinal tract characterized by chronic and relapsing inflammation. This study investigated anti-inflammatory effects Pyrus calleryana var. fauriei extract (PCE) in vitro vivo.BR/Methods Results: Lipopolysaccharide (LPS)-treated RAW 264.7 cells dextran sulfate sodium (DSS)-induced colitis mice were used to evaluate PCE. In cells, PCE inhibited nitric oxide production phagocytosis without cytotoxicity, pro-inflammatory cytokines tumor necrosis factor-α interleukin (IL)-6. Colitis was induced using 2% DSS for 5 days, administered 14 days. treatment relieved symptoms colitis, such as weight loss, diarrhea, bloody feces. Moreover, ameliorated splenomegaly colonic shortening, indicators colitis. reduced levels inflammatory cytokines, IL-6 IL-22. Histological analysis revealed that alleviated mucosal damage macrophage infiltration.BR/Conclusions: These results suggest has activity on LPS-treated ameliorates clinical DSS-induced mice. Therefore, potential therapeutic candidate IBD.

Language: Английский

Inflammation-Targeted Delivery of Probiotics for Alleviation of Colitis and Associated Cognitive Disorders through Improved Vitality and Colonization DOI
Yi Chen,

Mingju Shui,

Hongyi Li

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: 318, P. 123163 - 123163

Published: Feb. 1, 2025

Language: Английский

Citations

1
Rosmarinic acid-chondroitin sulfate nanoconjugate for targeted treatment of ulcerative colitis DOI

Miaomiao Long,

Jie Li,

Meiyang Yang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141008 - 141008

Published: Feb. 1, 2025

Language: Английский

Citations

1
Recent advances in dietary polyphenols (DPs): antioxidant activities, nutrient interactions, delivery systems, and potential applications DOI
Yalin Ran, Fuhua Li, Zhigang Xu

et al.

Food & Function, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

The antioxidant capacity of DPs is determined by internal chemical structures and environmental factors. Green delivery systems help improve their bioactivities bioavailability, providing great options for personalized food nutrition.

Language: Английский

Citations

4
Berberine‑calcium alginate-coated macrophage membrane-derived nanovesicles for the oral treatment of ulcerative colitis DOI
Huilin Ma, Y. Li, Huan Shi

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 294, P. 139114 - 139114

Published: Jan. 2, 2025

Language: Английский

Citations

0
Egg white-derived peptides co-assembly-reinforced zein/chondroitin sulfate nanoparticles for orally colon-targeted co-delivery of quercetin in colitis mitigation DOI

Sitong Ma,

Jingbo Liu, Yajuan Li

et al.

Food Bioscience, Journal Year: 2025, Volume and Issue: unknown, P. 106161 - 106161

Published: Feb. 1, 2025

Language: Английский

Citations

0
Efficacy of chondroitin sulfate as an emerging biomaterial for cancer-targeted drug delivery: A short review DOI
Sekar Vijayakumar, Zaira Isabel González-Sánchez, Mani Divya

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137704 - 137704

Published: Nov. 15, 2024

Language: Английский

Citations

1
Anti-inflammatory Effect of Pyrus calleryana var. fauriei on Dextran Sulfate Sodium-induced Acute Colitis in Mice and Lipopolysaccharide-treated RAW 264.7 cells DOI
Mi-Ra Lee, Bohye Kim, Hee‐Jun Kim

et al.

Korean Journal of Medicinal Crop Science, Journal Year: 2024, Volume and Issue: 32(6), P. 393 - 401

Published: Dec. 31, 2024

Back ground: Inflammatory bowel disease (IBD) is a pathological condition of the gastrointestinal tract characterized by chronic and relapsing inflammation. This study investigated anti-inflammatory effects Pyrus calleryana var. fauriei extract (PCE) in vitro vivo.BR/Methods Results: Lipopolysaccharide (LPS)-treated RAW 264.7 cells dextran sulfate sodium (DSS)-induced colitis mice were used to evaluate PCE. In cells, PCE inhibited nitric oxide production phagocytosis without cytotoxicity, pro-inflammatory cytokines tumor necrosis factor-α interleukin (IL)-6. Colitis was induced using 2% DSS for 5 days, administered 14 days. treatment relieved symptoms colitis, such as weight loss, diarrhea, bloody feces. Moreover, ameliorated splenomegaly colonic shortening, indicators colitis. reduced levels inflammatory cytokines, IL-6 IL-22. Histological analysis revealed that alleviated mucosal damage macrophage infiltration.BR/Conclusions: These results suggest has activity on LPS-treated ameliorates clinical DSS-induced mice. Therefore, potential therapeutic candidate IBD.

Language: Английский

Citations

0