Recent Applications of PLGA in Drug Delivery Systems
Jie Yang,
Huiying Zeng,
Yusheng Luo
и другие.
Polymers,
Год журнала:
2024,
Номер
16(18), С. 2606 - 2606
Опубликована: Сен. 14, 2024
Poly(lactic-co-glycolic
acid)
(PLGA)
is
a
widely
used
biodegradable
and
biocompatible
copolymer
in
drug
delivery
systems
(DDSs).
In
this
article,
we
highlight
the
critical
physicochemical
properties
of
PLGA,
including
its
molecular
weight,
intrinsic
viscosity,
monomer
ratio,
blockiness,
end
caps,
that
significantly
influence
release
profiles
degradation
times.
This
review
also
covers
extensive
literature
on
application
PLGA
delivering
small-molecule
drugs,
proteins,
peptides,
antibiotics,
antiviral
drugs.
Furthermore,
discuss
role
PLGA-based
DDSs
treating
various
diseases,
cancer,
neurological
disorders,
pain,
inflammation.
The
incorporation
drugs
into
nanoparticles
microspheres
has
been
shown
to
enhance
their
therapeutic
efficacy,
reduce
toxicity,
improve
patient
compliance.
Overall,
holds
great
promise
for
advancement
treatment
management
multiple
chronic
conditions.
Язык: Английский
Antibacterial hydrogels for bacteria-infected wound treatment
Biomedical Technology,
Год журнала:
2024,
Номер
9, С. 100066 - 100066
Опубликована: Ноя. 21, 2024
Язык: Английский
Molecularly and ionically imprinted polymers-based chemical sensors in chemical assays
Haiwen Su,
Haoyu Ren,
Xiayidan Maimaitikelimu
и другие.
Chemical Engineering Journal,
Год журнала:
2024,
Номер
unknown, С. 156315 - 156315
Опубликована: Сен. 1, 2024
Язык: Английский
Coupling simulation and experimental study of drug loading and releasing behaviors in phytol-based micelles
Journal of Molecular Liquids,
Год журнала:
2024,
Номер
416, С. 126225 - 126225
Опубликована: Окт. 12, 2024
Язык: Английский
Hierarchical adhesive hydrogel microparticles with galantamine hydrobromide encapsulation for Alzheimer’s disease
Materials & Design,
Год журнала:
2024,
Номер
unknown, С. 113322 - 113322
Опубликована: Сен. 1, 2024
Язык: Английский
Integrated Generation and Manipulation of Microcapsules via Optically Induced Dielectrophoresis
ACS Applied Polymer Materials,
Год журнала:
2024,
Номер
6(22), С. 13886 - 13895
Опубликована: Окт. 31, 2024
Microcapsules
have
a
wide
range
of
applications
in
the
medical
field,
but
their
fabrication
process
is
often
complicated
and
inefficient.
This
study
presents
method
that
uses
polystyrene
(PS)
microspheres
polyethylene
glycol
diacrylate
(PEGDA)
to
achieve
both
particle
positioning
polymerization
single
step
through
optically
induced
dielectrophoresis
(ODEP),
enabling
microcapsules
with
different
shapes.
The
maximum
speed
dielectrophoretic
force
1
10
μm
PS
are
investigated
solutions
PEGDA
concentrations
frequencies.
After
collected,
reaction
completed
original
solution.
In
addition,
by
extending
irradiation
time
light
source,
self-folding
two-dimensional
capsule
induced,
thereby
producing
particles
for
tubular
three-dimensional
shape.
innovation
holds
promise
various
targeted
treatment
diseases
diagnosis.
Язык: Английский
Study on the Pilot-Scale Technology of Ginkgolide B Synthesis by Coprinus comatus
Fermentation,
Год журнала:
2024,
Номер
10(11), С. 579 - 579
Опубликована: Ноя. 12, 2024
Ginkgo
biloba
extract
(EGB)
has
been
approved
by
the
Food
and
Drug
Administration
in
United
States
for
clinical
studies
on
memory
disorders.
Ginkgolide
B
(GB)
is
major
terpene
lactone
component
of
EGB
a
specific
potent
antagonist
platelet-activating
factor
(PAF).
In
previous
study,
we
reported
medium
composition
conversion
ginkgolides
to
GB
Coprinus
comatus.
present
applied
response
surface
methodology
(RSM)
optimize
conditions
20
L
fermenter
HPLC-MS/MS,
circular
dichroism
(CD)
infrared
(IR)
spectroscopy
analyses,
nuclear
magnetic
resonance
(NMR)
further
confirm
sample
structure.
The
optimal
consisted
12.7
L/min
ventilation,
156
h
time,
132
rpm
rotating
speed,
0.04
MPa
pressure,
27.8
°C
temperature.
Under
conditions,
rate
was
98.62%,
content
higher
than
98%.
CD,
IR,
NMR
analyses
showed
that
molecular
formula
C20H24O10
chemical
structure
good
agreement
with
standard
GB.
Our
current
study
lays
groundwork
industrial
production
Язык: Английский
Polymers Facilitating Therapeutic Efficacy and Applications for Traditional Chinese Medicine
Journal of Polymer Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 11, 2024
ABSTRACT
The
active
ingredients
from
traditional
Chinese
medicine
(TCM)
are
fundamental
to
its
therapeutic
efficacy.
However,
their
difficult
detection,
low
solubility,
poor
stability,
uncertain
biocompatibility,
and
inefficient
absorption
rate,
hinder
clinical
application.
Polymers
have
emerged
as
a
viable
solution
these
issues,
providing
platform
for
the
enrichment,
exertion
of
pharmacological
effects.
This
review
delves
into
application
polymers
in
TCM,
covering
various
aspects
including
molecularly
imprinted
(MIPs),
polymer
micelles,
hydrogels,
conjugated
polymers,
nanoparticles
(NPs).
These
advanced
systems
leverage
designability,
adjustable
biocompatibility
enhance
potential
TCM.
concludes
by
discussing
current
challenges
prospects
using
It
aims
provide
comprehensive
understanding
field,
highlighting
revolutionize
TCM
practices
contribute
modernization
Язык: Английский