Bioactive Materials,
Год журнала:
2024,
Номер
35, С. 82 - 98
Опубликована: Янв. 24, 2024
Repetitive
implant-related
infections
(IRIs)
are
devastating
complications
in
orthopedic
surgery,
threatening
implant
survival
and
even
the
life
of
host.
Biofilms
conceal
bacterial-associated
antigens
(BAAs)
result
a
"cold
tumor"-like
immune
silent
microenvironment,
allowing
persistence
IRIs.
To
address
this
challenge,
an
iron-based
covalent
organic
framed
nanoadjuvant
doped
with
curcumin
platinum
(CFCP)
was
designed
present
study
to
achieve
efficient
treatment
IRIs
by
inducing
systemic
response.
Specifically,
enhanced
sonodynamic
therapy
(SDT)
from
CFCP
combined
iron
ion
metabolic
interference
increased
release
double-stranded
DNA
(dsDNA).
Immunogenic
dsDNA
promoted
dendritic
cell
(DC)
maturation
through
activation
stimulator
interferon
gene
(STING)
amplified
stimulation
neutrophils
via
interferon-β
(IFN-β).
At
same
time,
BAA
presentation
aroused
humoral
immunity
B
T
cells,
creating
long-term
resistance
repetitive
infections.
Encouragingly,
served
as
neoadjuvant
immunotherapy
for
sustained
antibacterial
protection
on
implants
expected
guide
clinical
IRI
relapse
prevention.
Abstract
Nanomedicine‐assisted
sonodynamic
therapy
(SDT)
has
emerged
as
one
of
the
most
promising
cancer
therapies
due
to
its
unique
advantages
high
penetration,
non‐radiation,
and
excellent
oxidative
stress
effect,
but
always
suffered
from
self‐protection
mechanism
apoptosis
resistance
characteristics
evolutionarily
mutated
cells.
Regulated
cell
death
(RCD)
received
increasing
attention
in
precision
treatments
because
significant
role
synergistically
sensitizing
reversing
immunosuppressive
microenvironment
during
SDT
nanomedicine‐triggered
immunogenic
death.
Herein,
paradigmatic
research
RCD‐augmented
tumor
immunotherapeutics
are
typically
introduced,
such
autophagy
blockade,
ferroptosis
targeting,
pyroptosis
induction,
necroptosis
initiation,
cuproptosis
actuation,
PANoptosis
trigger,
coordinated
anti‐tumor
mechanisms
discussed
detail.
Multiple
analysis
focusing
on
currently
unsolved
problems
future
development
prospects
RCD‐based
nano‐oncology
medicine
also
prospected
further
strengthen
expand
scope
therapeutic
applications.
Advanced Materials,
Год журнала:
2024,
Номер
36(19)
Опубликована: Фев. 19, 2024
Abstract
Triggering
lysosome‐regulated
immunogenic
cell
death
(ICD,
e.g.,
pyroptosis
and
necroptosis)
with
nanomedicines
is
an
emerging
approach
for
turning
“immune‐cold”
tumor
“hot”—a
key
challenge
faced
by
cancer
immunotherapies.
Proton
sponge
such
as
high‐molecular‐weight
branched
polyethylenimine
(PEI)
excellent
at
rupturing
lysosomes,
but
its
therapeutic
application
hindered
uncontrollable
toxicity
due
to
fixed
charge
density
poor
understanding
of
resulted
mechanism.
Here,
a
series
proton
nano‐assemblies
(PSNAs)
self‐assembly
controllable
surface
cytotoxicity
are
created.
Such
PSNAs
constructed
via
low‐molecular‐weight
PEI
covalently
bound
self‐assembling
peptides
carrying
tetraphenylethene
pyridinium
(PyTPE,
aggregation‐induced
emission‐based
luminogen).
Assembly
assisted
the
peptide‐PyTPE
leads
enhanced
positive
charges
PSNA.
The
tendency
further
optimized
tuning
hydrophilic
hydrophobic
components
within
peptide,
thus
resulting
in
PSNA
highest
fluorescence,
density,
uptake,
cytotoxicity.
Systematic
mechanistic
studies
reveal
that
lysosome
rupturing‐regulated
necroptosis
least
two
causes
death.
Tumor
cells
undergoing
PSNA‐triggered
ICD
activate
immune
cells,
suggesting
great
potential
trigger
anticancer
immunity.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(30)
Опубликована: Март 22, 2024
Abstract
Sonosensitizers
in
current
sonodynamic
therapy
(SDT)
often
suffer
from
poor
delivery
efficiency,
phototoxicity,
and
disputed
safety.
To
overcome
these
issues,
a
sonosensitizers‐free
sonocatalytic
nanomissile
is
constructed,
wherein
PLGA
nanoparticles
as
vehicles
conjugate
with
L‐arginine
(LA)
aptamer
XQ2d
capable
of
adsorbing
CO
2
targeting
CD71‐overexpressed
pancreatic
cancer,
respectively.
The
adsorbed
can
respond
to
acidic
tumor
microenvironment
local
ultrasound
release
bubbles
enhance
ultrasound‐triggered
inertial
cavitation,
which
further
split
H
O
activate
dissolved
produce
·OH
1
,
respectively,
unlocking
the
ROS
birth.
Moreover,
such
bubbles‐enhanced
cavitation
also
target
intratumoral
vascular
destruction,
instigate
thrombus
aggregation,
induce
nutrition
oxygen
deprivation,
pose
hypoxia
alter
metabolism,
thus
establishing
an
destruction‐targeted
starvation
therapy.
strategy
different
previous
presence
undamaged
blood
vessels
compromises
their
outcomes.
Especially,
active
allows
more
sonosensitizer‐free
nanomissiles
retain
significantly
magnifying
against
subcutaneous
orthotopic
cancers.
Therefore,
research
provides
promising
route
therapeutic
platform
for
clinical
cancer
ACS Nano,
Год журнала:
2024,
Номер
18(13), С. 9413 - 9430
Опубликована: Март 24, 2024
Personalized
in
situ
tumor
vaccination
is
a
promising
immunotherapeutic
modality.
Currently,
seeking
immunogenic
cell
death
(ICD)
to
generate
vaccines
still
mired
by
insufficient
immunogenicity
and
an
entrenched
immunosuppressive
microenvironment
(TME).
Herein,
series
of
tetrazine-functionalized
ruthenium(II)
sonosensitizers
have
been
designed
screened
for
establishing
bioorthogonal-activated
vaccine
via
oncolytic
pyroptosis
induction.
Based
on
nanodelivery-augmented
bioorthogonal
metabolic
glycoengineering,
the
original
selectively
remolded
introduce
artificial
target
bicycle
[6.1.0]
nonyne
(BCN)
into
membrane.
Through
specific
ligation
with
intratumoral
BCN
receptors,
can
realize
precise
membrane-anchoring
synchronous
click-activation
desired
sites.
Upon
ultrasound
(US)
irradiation,
activated
intensively
disrupt
membrane
dual
type
I/II
reactive
oxygen
species
(ROS)
generation
high-efficiency
sonodynamic
therapy
(SDT).
More
importantly,
severe
damage
eminently
evoke
maximize
reverse
TME,
ultimately
eliciting
powerful
durable
systemic
antitumor
immunity.
The
US-triggered
certified
effectively
inhibit
growths
primary
distant
tumors,
suppress
metastasis
recurrence
"cold"
models.
This
bioorthogonal-driven
tumor-specific
induction
strategy
has
great
potential
development
robust
vaccines.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(37)
Опубликована: Апрель 11, 2024
Abstract
Cancer
cell‐triggered
sol–gel
transformation
of
mineralized
hydrogel
(PAA‐MnO
2
)
is
designed
as
a
facile
strategy
for
cancer
detection
by
manipulating
the
mineralization
process
in
presence
cells.
The
polyacrylic
acid
(PAA)
with
calcium
phosphate
via
carboxyl‐Ca
2+
complex
initially
inhibited
incorporation
reactive
oxygen
species
(ROS)‐sensitive
manganese
oxide
(MnO
polymer
dots
(PDs).
In
this
system,
can
be
induced
after
cleaving
MnO
into
Mn
high
ROS
levels
cells,
forming
PAA‐MnO
and
resulting
naked‐eye
system
monitoring.
Naked‐eye
monitoring
ROS‐responsive
performed
using
circulator
device
containing
circulating
cells
to
discriminate
(HeLa,
PC‐3,
B16F10)
from
normal
(CHO‐K1).
With
PDs,
not
only
provides
physical
(stretchability,
viscosity)
but
also
fluorescence‐recovery
electroconductivity
changes
at
different
cancer‐cell
concentrations
(10
4
–10
6
mL
−1
),
including
distinct
strain–pressure
responses
that
wirelessly
monitored
smartphones.
Furthermore,
vivo,
experiments
suggest
formed
tumor‐bearing
mice
owing
its
excellent
ROS‐scavenging
activity
tumor
site,
confirmed
SOD2
gene‐expression
analysis.
Thus,
unique
approach
potentially
enable
simple
effective
future
point‐of‐care
diagnostics.
