International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(15), С. 8540 - 8540
Опубликована: Авг. 5, 2024
Damage
to
the
central
nervous
system
(CNS)
often
leads
irreversible
neurological
deficits,
and
there
are
currently
few
effective
treatments
available.
However,
recent
advancements
in
regenerative
medicine
have
identified
CNS
organoids
as
promising
therapeutic
options
for
addressing
injuries.
These
organoids,
composed
of
various
neurons
supporting
cells,
shown
potential
direct
repair
at
injury
sites.
resemble
structure
function
actual
brain
tissue,
which
allows
them
adapt
well
within
physiological
environment
when
transplanted
into
Research
findings
suggest
that
can
replace
damaged
neurons,
form
new
neural
connections,
promote
recovery.
This
review
highlights
emerging
benefits,
evaluates
preclinical
transplantation
outcomes,
explores
future
strategies
optimizing
neuroregeneration
using
organoids.
With
continued
research
technological
advancements,
these
could
provide
hope
patients
suffering
from
deficits.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 24, 2025
Abstract
The
complexity
and
precision
of
the
human
nervous
system
have
posed
significant
challenges
for
researchers
seeking
suitable
models
to
elucidate
refractory
neural
disorders.
Traditional
approaches,
including
monolayer
cell
cultures
animal
models,
often
fail
replicate
intricacies
tissue.
advent
organoid
technology
derived
from
stem
cells
has
addressed
many
these
limitations,
providing
highly
representative
platforms
studying
structure
function
embryonic
brain
spinal
cord.
Researchers
induced
organoids
with
regional
characteristics
by
mimicking
morphogen
gradients
in
development.
Recent
advancements
demonstrated
utility
disease
modeling,
offering
insights
into
pathophysiology
various
disorders,
as
well
field
regeneration.
Developmental
defects
due
lack
microglia
or
vascular
systems
are
addressed.
In
addition
induction
methods,
microfluidics
is
used
simulate
dynamic
physiological
environment;
bio‐manufacturing
technologies
employed
regulate
physical
signaling
shape
complex
organs.
These
further
expand
construction
strategies
application
scope
organoids.
With
emergence
new
material
paradigms
advances
AI,
possibilities
realm
witnessed.
Reviews in the Neurosciences,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 27, 2025
Abstract
For
several
decades,
the
modeling
of
brain
diseases
in
experimental
animals
has
remained
one
key
components
studying
pathogenesis
central
nervous
system
pathology
and
searching
for
new
methods
prevention
therapy.
In
recent
years,
approaches
to
pathological
conditions
vitro
have
been
active
development;
these
will
not
only
reduce
number
animal
studies
but
also
allow
us
take
a
step
toward
reproducing
human-specific
mechanisms
pathology.
this
review,
we
characterize
most
common
rodent
models
cerebral
ischemia
reperfusion,
as
well
neuroinflammation
inherent
neurodegeneration
(in
particular,
Parkinson’s
disease),
which
are
reproduced
vivo
.
This
review
addresses
engineering
technical
challenges
prospects
development
,
e.g.,
vascularized
microglia-containing/neuroimmune
organoids,
may
be
useful
overcoming
shortcomings
limitations
current
models.
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(15), С. 8540 - 8540
Опубликована: Авг. 5, 2024
Damage
to
the
central
nervous
system
(CNS)
often
leads
irreversible
neurological
deficits,
and
there
are
currently
few
effective
treatments
available.
However,
recent
advancements
in
regenerative
medicine
have
identified
CNS
organoids
as
promising
therapeutic
options
for
addressing
injuries.
These
organoids,
composed
of
various
neurons
supporting
cells,
shown
potential
direct
repair
at
injury
sites.
resemble
structure
function
actual
brain
tissue,
which
allows
them
adapt
well
within
physiological
environment
when
transplanted
into
Research
findings
suggest
that
can
replace
damaged
neurons,
form
new
neural
connections,
promote
recovery.
This
review
highlights
emerging
benefits,
evaluates
preclinical
transplantation
outcomes,
explores
future
strategies
optimizing
neuroregeneration
using
organoids.
With
continued
research
technological
advancements,
these
could
provide
hope
patients
suffering
from
deficits.
