International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(15), P. 8540 - 8540
Published: Aug. 5, 2024
Damage
to
the
central
nervous
system
(CNS)
often
leads
irreversible
neurological
deficits,
and
there
are
currently
few
effective
treatments
available.
However,
recent
advancements
in
regenerative
medicine
have
identified
CNS
organoids
as
promising
therapeutic
options
for
addressing
injuries.
These
organoids,
composed
of
various
neurons
supporting
cells,
shown
potential
direct
repair
at
injury
sites.
resemble
structure
function
actual
brain
tissue,
which
allows
them
adapt
well
within
physiological
environment
when
transplanted
into
Research
findings
suggest
that
can
replace
damaged
neurons,
form
new
neural
connections,
promote
recovery.
This
review
highlights
emerging
benefits,
evaluates
preclinical
transplantation
outcomes,
explores
future
strategies
optimizing
neuroregeneration
using
organoids.
With
continued
research
technological
advancements,
these
could
provide
hope
patients
suffering
from
deficits.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(17), P. 9747 - 9747
Published: Sept. 9, 2024
Experimental
models
play
a
pivotal
role
in
biomedical
research,
facilitating
the
understanding
of
disease
mechanisms
and
development
novel
therapeutics.
This
is
particularly
true
for
neurodegenerative
diseases,
such
as
Alzheimer’s
disease,
Parkinson’s
Huntington’s
amyotrophic
lateral
sclerosis,
motor
neuron
which
present
complex
challenges
research
therapy
development.
In
this
work,
we
review
recent
literature
about
experimental
disease.
We
identified
three
main
categories
that
are
highly
studied
by
scientists.
fact,
investigating
these
diseases
encompass
variety
approaches,
including
modeling
patient’s
cell
culture,
patient-derived
induced
pluripotent
stem
cells,
organoids.
Each
model
offers
unique
advantages
limitations,
providing
researchers
with
range
tools
to
address
biological
questions.
Here,
discuss
characteristics,
applications,
advancements
terms
each
system,
highlighting
their
contributions
advancing
knowledge
translational
research.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(15), P. 8540 - 8540
Published: Aug. 5, 2024
Damage
to
the
central
nervous
system
(CNS)
often
leads
irreversible
neurological
deficits,
and
there
are
currently
few
effective
treatments
available.
However,
recent
advancements
in
regenerative
medicine
have
identified
CNS
organoids
as
promising
therapeutic
options
for
addressing
injuries.
These
organoids,
composed
of
various
neurons
supporting
cells,
shown
potential
direct
repair
at
injury
sites.
resemble
structure
function
actual
brain
tissue,
which
allows
them
adapt
well
within
physiological
environment
when
transplanted
into
Research
findings
suggest
that
can
replace
damaged
neurons,
form
new
neural
connections,
promote
recovery.
This
review
highlights
emerging
benefits,
evaluates
preclinical
transplantation
outcomes,
explores
future
strategies
optimizing
neuroregeneration
using
organoids.
With
continued
research
technological
advancements,
these
could
provide
hope
patients
suffering
from
deficits.
