Mesenchymal stromal cell-derived extracellular vesicles as nanotherapeutics for concanavalin a-induced hepatitis: modulating the gut‒liver axis
Stem Cell Research & Therapy,
Год журнала:
2025,
Номер
16(1)
Опубликована: Янв. 7, 2025
As
cell-free
nanotherapeutics,
extracellular
vesicles
derived
from
mesenchymal
stem
cells
(MSC-EVs)
have
shown
potential
therapeutic
action
against
liver
diseases.
However,
their
effects
on
autoimmune
hepatitis
(AIH)
are
not
yet
well
understood.
In
this
study,
we
utilized
a
well-established
concanavalin
A
(Con
A)-induced
fulminant
mouse
model
to
investigate
the
of
MSC-EVs
AIH.
We
found
that
provide
significant
protection
Con
A-induced
in
C57BL/6
male
mice,
with
effectiveness
being
critically
dependent
gut
microbiota.
modulate
composition
microbiota,
particularly
by
increasing
abundance
norank_f__Muribaculaceae,
and
impact
metabolic
profiles,
leading
amelioration
injury.
The
identification
Acetyl-DL-Valine
as
protective
metabolite
underscores
targeting
gut‒liver
axis
interactions
Overall,
our
data
demonstrate
exhibit
nanotherapeutic
new
insights
into
treatment
hepatitis.
Язык: Английский
Exploring the Potential of Stem Cells in Modulating Gut Microbiota and Managing Hypertension
Stem Cells and Development,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 21, 2025
Hypertension,
commonly
known
as
high
blood
pressure,
is
a
significant
health
issue
that
increases
the
risk
of
cardiovascular
diseases,
stroke,
and
renal
failure.
This
condition
broadly
encompasses
both
primary
secondary
forms.
Despite
extensive
research,
underlying
mechanisms
systemic
arterial
hypertension-particularly
hypertension,
which
has
no
identifiable
cause
affected
by
genetic
lifestyle
agents-remain
complex
not
fully
understood.
Recent
studies
indicate
an
imbalance
in
gut
microbiota,
referred
to
dysbiosis,
may
promote
affecting
pressure
regulation
through
metabolites
such
short-chain
fatty
acids
trimethylamine
N-oxide.
Current
antihypertensive
medications
face
limitations,
including
resistance
adherence
issues,
highlighting
need
for
novel
therapeutic
approaches.
Stem
cell
therapy,
emerging
field
regenerative
medicine,
shows
promise
addressing
these
challenges.
cells,
with
mesenchymal
stem
cells
being
prime
example,
have
regenerative,
anti-inflammatory,
immunomodulatory
properties.
Emerging
research
indicates
can
modulate
reduce
inflammation,
improve
vascular
health,
potentially
aiding
management.
Research
shown
positive
impact
on
microbiota
various
disorders,
suggesting
their
potential
role
treating
hypertension.
review
synthesizes
recent
interactions
between
By
offering
thorough
analysis
current
literature,
it
highlights
key
insights,
uncovers
critical
gaps,
identifies
trends
will
inform
guide
future
investigations
this
rapidly
advancing
field.
Язык: Английский
Hidden Partner of Immunity: Microbiome as an Innovative Companion in Immunotherapy
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(2), С. 856 - 856
Опубликована: Янв. 20, 2025
Recent
studies
have
highlighted
that
the
microbiome
is
essential
factor
can
modulate
clinical
activity
of
immunotherapy.
However,
role
varies
significantly
across
different
immunotherapies,
suggesting
it
critical
to
understand
precise
function
in
each
type
While
many
previous
primarily
focus
on
summarizing
immune
checkpoint
inhibitors,
we
seek
explore
a
novel
aspect
other
immunotherapies
such
as
mesenchymal
stem
cell
therapy,
chimeric
antigen
receptor
T
and
antibodies-based
therapy
(e.g.,
adalimumab,
infliximab,
bevacizumab,
denosumab,
etc.)
which
are
rarely
summarized
reviews.
Moreover,
highlight
innovative
strategies
for
utilizing
microbial
metabolites
enhance
response
Collectively,
believe
our
manuscript
will
provide
insights
approaches
researchers,
could
drive
development
next
generation
personalized
therapeutic
interventions
using
microbiomes.
Язык: Английский
Exploring Extracellular Vesicles: A Novel Approach in Nonalcoholic Fatty Liver Disease
Ana Isabel Vigil Medina,
Mengdie Shi,
Yanyan Wang
и другие.
Journal of Agricultural and Food Chemistry,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 23, 2025
Nonalcoholic
fatty
liver
disease
(NAFLD)
represents
an
increasing
public
health
concern.
The
underlying
pathophysiological
mechanisms
of
NAFLD
remains
unclear,
and
as
a
result,
there
is
currently
no
specific
therapy
for
this
condition.
However,
recent
studies
focus
on
extracellular
vesicles
(EVs)
novelty
in
their
role
cellular
communication.
An
imbalance
the
gut
microbiota
composition
may
contribute
to
progression
NAFLD,
making
gut-liver
axis
promising
target
therapeutic
strategies.
This
review
aims
provide
comprehensive
overview
EVs
NAFLD.
Additionally,
exosome-like
nanovesicles
derived
from
plants
(PELNs)
probiotics-derived
(postbiotics)
have
demonstrated
potential
re-establish
intestinal
equilibrium
modulate
microbiota,
thus
offering
alleviate
via
axis.
Further
research
needed
using
multiple
omics
approaches
comprehensively
characterize
cargo
including
protein,
metabolites,
genetic
material
packaged,
biological
activities
diverse
microbes
plants.
Язык: Английский
Effect of betaine on growth performance, methionine metabolism, and methyl transfer in broilers aged 1 to 21 days and fed a low-methionine diet
The Journal of Poultry Science,
Год журнала:
2025,
Номер
62(0), С. n/a - n/a
Опубликована: Янв. 1, 2025
Betaine
has
been
proposed
as
a
low-cost
source
of
methyl
groups
in
poultry
feed,
replacing
methionine
and
choline.
The
present
study
aimed
to
investigate
the
effect
betaine
on
growth
performance,
metabolism,
transfer
broilers
aged
1
21
days
fed
low-methionine
diet.
A
total
960
one-day-old
male
were
randomly
divided
into
four
groups:
positive
control
(0.62%
diet),
negative
(0.37%
two
treatment
diet
plus
either
1500
or
3000
mg
betaine/kg
diet).
Chicks
had
highest
feed-to-gain
ratio
(P
<
0.05),
but
no
significant
difference
final
body
weight,
average
daily
gain,
feed
intake,
mortality.
Serum
S-adenosyl-L-methionine
homocysteine
higher
at
diet;
whereas
serum
S-adenosylhomocysteine
exhibited
opposite
trend.
Except
for
DNA
methyltransferase
1,
key
enzymes
metabolites
involved
hepatic
single-carbon
pathway
showed
levels
declined
thereafter.
Furthermore,
promoted
dose-dependent
mRNA
protein
expression
metabolic
cycle
transferase
pathways
chicks
methionine-deficient
diets.
In
conclusion,
while
addition
did
not
significantly
improve
performance
1-21
days,
inclusion
effectively
stabilized
metabolism
Язык: Английский
Promising nanotherapeutics of stem cell extracellular vesicles in liver regeneration
Regenerative Therapy,
Год журнала:
2024,
Номер
26, С. 1037 - 1047
Опубликована: Июнь 1, 2024
Язык: Английский
Pretreatment of Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes with Quercetin Enhances the Healing of Diabetic Skin Wounds by Modulating Host-Microbiota Interactions
Shuhui Wu,
Zhongsheng Zhou,
Yang Li
и другие.
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 12557 - 12581
Опубликована: Ноя. 1, 2024
Owing
to
the
distinctive
advantages
of
mesenchymal
stem
cell-derived
exosomes
(MSCs-exo),
these
vesicles
have
emerged
as
a
pivotal
research
focus
in
regenerative
medicine,
surpassing
their
MSC
counterparts.
Quercetin
(Qr),
widely
recognized
for
its
potent
anti-inflammatory
and
antioxidant
activities,
demonstrates
substantial
potential
enhancing
tissue
repair
processes.
This
study
delves
into
role
quercetin-pretreated
MSC-derived
(MSCs
Язык: Английский
Bacteroides Fragilis Exacerbates T2D Vascular Calcification by Secreting Extracellular Vesicles to Induce M2 Macrophages
Advanced Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 12, 2024
Abstract
Vascular
calcification
(VC)
in
type
2
diabetes
(T2D)
poses
a
serious
threat
to
the
life
and
health
of
patients.
However,
its
pathogenesis
remains
unclear,
resulting
lack
effective
treatment
for
root
cause.
It
is
found
that
both
intestinal
Bacteroides
fragilis
(BF)
peripheral
M2
monocytes/macrophages
are
significantly
elevated
patients
with
T2D
VC.
macrophages
identified
as
significant
risk
factor
Both
BF
their
extracellular
vesicles
(EV)
promote
VC
facilitate
macrophage
polarization.
Macrophages
clearance
antagonized
EV‐induced
mice.
Mechanistically,
EV‐rich
double‐stranded
DNA
(dsDNA)
activates
stimulator
interferon
response
cGAMP
interactor
1
(Sting),
promotes
myocyte
enhancer
2D
(Mef2d)
phosphorylation,
upregulates
tribbles
pseudokinase
(Trib1)
expression,
induces
Concurrently,
Mef2d
activated
by
EV
targets
expression
pro‐calcification
Serpine1,
thereby
exacerbating
Clinical
studies
have
shown
Serpine1
blood
closely
associated
In
summary,
this
study
reveals
Trib1
through
EV‐Sting‐Mef2d
pathway
induce
polarization
serpin
family
E
member
(Serpine1)
aggravating
The
findings
provide
new
theoretical
experimental
bases
optimizing
strategies
prevention
Язык: Английский