Robustly Injectable Tetra‐PEG Hydrogel Sealants for Annulus Fibrosus Repair DOI
Guoke Tang,

Yucai Li,

Yi Liu

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 24, 2024

Abstract Discectomy serves as the primary therapeutic approach for lumbar disc herniation, but annular fibrosus defects after discectomy may lead to recurrence of herniation. Despite recent advances in bioinspired adhesives seal AF defect, growing popularity endoscopic has put forward high requirements tissue bioadhesives with rapid injectability, easy operation, and robust adhesion underwater environments. Herein, a rapidly situ forming injectable tetra‐PEG bioadhesive (ISG) comprising FDA‐approved tetra‐armed poly (ethylene glycol) amine (tetra‐PEG‐NH 2 ) succinimidyl glutarate (tetra‐PEG‐SG) sutureless closure defects, is reported. Relying on quick ammonolysis reaction between N‐hydroxysuccinimide (NHS)‐ester tetra‐PEG‐SG polymer groups tetra‐PEG‐NH proteins, uniform networks are formed within seconds injection, efficient waterproofness, instant adhesion, durable compliance. The goat model was used assess effect ISG hydrogels vivo. results reveal that resultant can effectively maintain height, fuse host tissue, ameliorate IVD degeneration, retain initial biomechanics. Together, this study provides an strategy glue minimally invasive treatment defects.

Язык: Английский

An anisotropic damage visco-hyperelastic model for multiaxial stress-strain response and energy dissipation in filled rubber DOI

Lionel Ogouari,

Qiang Guo, Fahmi Zaïri

и другие.

International Journal of Plasticity, Год журнала: 2024, Номер 182, С. 104111 - 104111

Опубликована: Авг. 30, 2024

Язык: Английский

Процитировано

6

Force-induced length-change effect of macromolecular chains undergoing mechanochemical coupling and mechanical behaviors under uniaxial tension in soft hydrogels DOI

Weilin Shi,

Yuheng Liu, Haibao Lu

и другие.

Mechanics of Materials, Год журнала: 2025, Номер unknown, С. 105276 - 105276

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0

An anisotropic constitutive relationship by a series of 8 chain models DOI
Libin Yang, Teng Long, Lixiang Yang

и другие.

International Journal of Solids and Structures, Год журнала: 2025, Номер unknown, С. 113288 - 113288

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0

A combined numerical and theoretical study on the strengthening and toughening mechanisms of double network hydrogels DOI Creative Commons
Bo Gong, Ji Lin, Yu Xie

и другие.

International Journal of Smart and Nano Materials, Год журнала: 2025, Номер unknown, С. 1 - 25

Опубликована: Март 15, 2025

Язык: Английский

Процитировано

0

Tensile Behaviors of Double Network Hydrogels with Varied First Network Topological and Chemical Structures DOI
Fei-Xue Lu, Tasuku Nakajima, Yong Zheng

и другие.

Macromolecules, Год журнала: 2024, Номер unknown

Опубликована: Дек. 7, 2024

Язык: Английский

Процитировано

1

Insights on the Influence of Functional Side Groups on the Mechanical Performance of Poly(2-oxazoline)/Poly(acrylate) Double Network Hydrogels DOI Creative Commons

Paola Andrea Benitez-Duif,

Sebastian Weckes,

Ricardo Ferreira

и другие.

Polymer, Год журнала: 2024, Номер unknown, С. 128014 - 128014

Опубликована: Дек. 1, 2024

Язык: Английский

Процитировано

1

Robustly Injectable Tetra‐PEG Hydrogel Sealants for Annulus Fibrosus Repair DOI
Guoke Tang,

Yucai Li,

Yi Liu

и другие.

Advanced Healthcare Materials, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 24, 2024

Abstract Discectomy serves as the primary therapeutic approach for lumbar disc herniation, but annular fibrosus defects after discectomy may lead to recurrence of herniation. Despite recent advances in bioinspired adhesives seal AF defect, growing popularity endoscopic has put forward high requirements tissue bioadhesives with rapid injectability, easy operation, and robust adhesion underwater environments. Herein, a rapidly situ forming injectable tetra‐PEG bioadhesive (ISG) comprising FDA‐approved tetra‐armed poly (ethylene glycol) amine (tetra‐PEG‐NH 2 ) succinimidyl glutarate (tetra‐PEG‐SG) sutureless closure defects, is reported. Relying on quick ammonolysis reaction between N‐hydroxysuccinimide (NHS)‐ester tetra‐PEG‐SG polymer groups tetra‐PEG‐NH proteins, uniform networks are formed within seconds injection, efficient waterproofness, instant adhesion, durable compliance. The goat model was used assess effect ISG hydrogels vivo. results reveal that resultant can effectively maintain height, fuse host tissue, ameliorate IVD degeneration, retain initial biomechanics. Together, this study provides an strategy glue minimally invasive treatment defects.

Язык: Английский

Процитировано

0