Immune mechanisms in fibrotic interstitial lung disease

Cell, Год журнала: 2024, Номер 187(14), С. 3506 - 3530

Опубликована: Июль 1, 2024

Язык: Английский

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Targeting pathogenic fibroblast-like synoviocyte subsets in rheumatoid arthritis

Arthritis Research & Therapy, Год журнала: 2024, Номер 26(1)

Опубликована: Май 23, 2024

Abstract Fibroblast-like synoviocytes (FLSs) play a central role in RA pathogenesis and are the main cellular component inflamed synovium of patients with rheumatoid arthritis (RA). FLSs emerging as promising new therapeutic targets RA. However, fibroblasts perform many essential functions that required for sustaining tissue homeostasis. Direct targeting general fibroblast markers on is challenging because other tissues might be altered side effects such reduced wound healing or fibrosis can occur. To date, no FLS-specific targeted therapies have been applied clinical management With help high-throughput technologies scRNA-seq recent years, several specific pathogenic FLS subsets identified. Understanding characteristics these clusters mechanisms drive their differentiation provide insights into development novel FLS-targeting strategies Here, we discuss elucidated years potential FLSs.

Язык: Английский

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The chromatin landscape of pathogenic transcriptional cell states in rheumatoid arthritis

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Май 31, 2024

Abstract Synovial tissue inflammation is a hallmark of rheumatoid arthritis (RA). Recent work has identified prominent pathogenic cell states in inflamed RA synovial tissue, such as T peripheral helper cells; however, the epigenetic regulation these yet to be defined. Here, we examine genome-wide open chromatin at single-cell resolution 30 samples, including 12 samples with transcriptional data multimodal experiments. We identify 24 classes and predict their associated transcription factors, CD8 + GZMK class EOMES lining fibroblast AP-1. By integrating an atlas, propose that represent ‘superstates’ corresponding multiple states. Finally, demonstrate utility this atlas through associations between disease phenotypes abundance, well nomination mediating effects putatively causal genetic variants.

Язык: Английский

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Sequential immunotherapy: towards cures for autoimmunity

Nature Reviews Drug Discovery, Год журнала: 2024, Номер 23(7), С. 501 - 524

Опубликована: Июнь 5, 2024

Язык: Английский

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S100A4 a classical DAMP as a therapeutic target in fibrosis

Matrix Biology, Год журнала: 2024, Номер unknown

Опубликована: Янв. 1, 2024

Язык: Английский

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