medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Март 6, 2023
Abstract
Background
While
anti-SARS-CoV-2
antibody
kinetics
have
been
well
described
in
large
populations
of
vaccinated
individuals,
we
still
poorly
understand
how
they
evolve
during
a
natural
infection
and
this
impacts
viral
clearance.
Methods
For
that
purpose,
analyzed
the
both
load
neutralizing
levels
prospective
cohort
individuals
acute
by
Alpha
variant.
Results
Using
mathematical
model,
show
progressive
increase
antibodies
leads
to
shortening
half-life
infected
cells
infectious
particles.
We
estimated
activity
reached
90%
its
maximal
level
within
8
days
after
symptoms
onset
could
reduce
virus
6-fold
factor,
thus
playing
key
role
achieve
rapid
conducted
simulation
study
predict
more
general
context
protection
conferred
existence
pre-existing
neutralization,
due
either
vaccination
or
prior
infection.
predicted
activity,
as
measured
ED
50
>10
3
,
50%
risk
having
detectable
standard
PCR
assays
99%
above
threshold
cultivable
virus.
Conclusions
This
value
for
be
used
identify
with
poor
against
disease
acquisition.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2021,
Номер
unknown
Опубликована: Дек. 25, 2021
The
latest
SARS-CoV-2
variant
of
concern
Omicron,
with
its
immune
escape
from
therapeutic
anti-Spike
monoclonal
antibodies
and
WA-1
vaccine-elicited
sera,
demonstrates
the
continued
relevance
COVID-19
convalescent
plasma
(CCP)
therapies.
Lessons
learnt
previous
usage
CCP
suggests
focusing
on
early
outpatients
immunocompromised
recipients,
high
neutralizing
antibody
(nAb)
titer
units.
In
this
analysis
we
systematically
reviewed
Omicron-neutralizing
activity
data,
found
that
approximately
47%
(424/902)
unvaccinated
pre-Omicron
donors
neutralizes
Omicron
BA.1
a
very
low
geomean
geometric
mean
titers
for
50%
neutralization
GM(GMT
Biomedicines,
Год журнала:
2022,
Номер
10(11), С. 2966 - 2966
Опубликована: Ноя. 17, 2022
Airborne
pathogens,
including
SARS-CoV-2,
are
mainly
contracted
within
the
airway
pathways,
especially
in
nasal
epithelia,
where
inhaled
air
is
mostly
filtered
resting
conditions.
Mucosal
immunity
developing
after
SARS-CoV-2
infection
or
vaccination
this
part
of
body
represents
one
most
efficient
deterrents
for
preventing
viral
infection.
Nonetheless,
complete
lack
such
protection
naïve
seronegative
subjects,
limited
capacity
neutralizing
new
and
highly
mutated
lineages,
along
with
progressive
waning
mucosal
over
time,
lead
way
to
considering
alternative
strategies
constructing
walls
that
could
stop
entrap
virus
at
mucosa
surface,
which
area
primarily
colonized
by
Omicron
sublineages.
Among
various
preventive
strategies,
those
based
on
generating
physical
barriers
nose,
aimed
impeding
host
cell
penetration
(i.e.,
using
compounds
mucoadhesive
properties,
act
hindering,
entrapping
adsorbing
virus),
association
its
cellular
receptors
administering
anti-SARS-CoV-2
antibodies
agents
inhibit
priming
binding
spike
protein)
be
considered
appealing
perspectives.
Provided
these
proven
safe,
comfortable,
compatible
daily
life,
we
suggest
prioritizing
their
usage
subjects
enhanced
risk
contagion,
during
high-risk
activities,
as
well
patients
more
likely
develop
severe
forms
The Journal of Infectious Diseases,
Год журнала:
2023,
Номер
228(12), С. 1652 - 1661
Опубликована: Сен. 26, 2023
Abstract
Background
Data
are
limited
on
the
role
of
preinfection
humoral
immunity
protection
against
Omicron
BA.5
infection
and
long
coronavirus
disease
(COVID)
development.
Methods
We
conducted
nested
case-control
analysis
among
tertiary
hospital
staff
in
Tokyo
who
donated
blood
samples
June
2022
(1
month
before
wave),
approximately
6
months
after
receiving
a
third
dose
COVID-19
mRNA
vaccine.
measured
live
virus-neutralizing
antibody
titers
wild
type
BA.5,
anti–receptor-binding
domain
(RBD)
at
preinfection,
compared
them
between
cases
propensity-matched
controls.
Among
breakthrough
cases,
we
examined
association
incidence
COVID.
Results
Preinfection
anti-RBD
neutralizing
were
lower
than
Neutralizing
64%
(95%
confidence
interval
[CI],
42%–77%)
72%
CI,
53%–83%)
lower,
respectively,
Individuals
with
previous
BA.1/BA.2
infections
more
frequent
controls
(10.3%
vs
0.8%),
their
12.8-fold
higher
infection-naive
individuals.
not
associated
Conclusions
immunogenicity
severe
acute
respiratory
syndrome
2
(SARS-CoV-2)
may
play
protecting
but
preventing
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Март 6, 2023
Abstract
Background
While
anti-SARS-CoV-2
antibody
kinetics
have
been
well
described
in
large
populations
of
vaccinated
individuals,
we
still
poorly
understand
how
they
evolve
during
a
natural
infection
and
this
impacts
viral
clearance.
Methods
For
that
purpose,
analyzed
the
both
load
neutralizing
levels
prospective
cohort
individuals
acute
by
Alpha
variant.
Results
Using
mathematical
model,
show
progressive
increase
antibodies
leads
to
shortening
half-life
infected
cells
infectious
particles.
We
estimated
activity
reached
90%
its
maximal
level
within
8
days
after
symptoms
onset
could
reduce
virus
6-fold
factor,
thus
playing
key
role
achieve
rapid
conducted
simulation
study
predict
more
general
context
protection
conferred
existence
pre-existing
neutralization,
due
either
vaccination
or
prior
infection.
predicted
activity,
as
measured
ED
50
>10
3
,
50%
risk
having
detectable
standard
PCR
assays
99%
above
threshold
cultivable
virus.
Conclusions
This
value
for
be
used
identify
with
poor
against
disease
acquisition.
