Engineering Cells for Cancer Therapy
Accounts of Chemical Research,
Год журнала:
2024,
Номер
57(16), С. 2358 - 2371
Опубликована: Авг. 2, 2024
ConspectusCells,
particularly
living
cells,
serve
as
natural
carriers
of
bioactive
substances.
Their
inherent
low
immunogenicity
and
multifunctionality
have
garnered
significant
attention
in
the
realm
disease
treatment
applications,
specifically
within
domains
cancer
immunotherapy
regenerative
tissue
repair.
Nevertheless,
several
prominent
challenges
impede
their
swift
translation
into
clinical
including
obstacles
related
to
large-scale
production
feasibility
high
utilization
costs.
To
address
these
issues
comprehensively,
researchers
proposed
notion
bionic
cells
that
are
synthetically
generated
through
chemical
or
biosynthetic
means
emulate
cellular
functions
behaviors.
However,
artificial
cell
strategies
encounter
difficulties
fully
replicating
intricate
functionalities
exhibited
by
while
also
grappling
with
complexities
associated
design
implementation
for
purposes.
The
convergence
disciplines
has
facilitated
reform
a
range
approaches,
chemical-,
biological-,
genetic-,
materials-based
methods.
These
techniques
can
be
employed
impart
specific
enhance
efficacy
therapy.
For
example,
engineered
gene
transduction,
surface
modifications,
endocytosis
drugs
delivery
systems,
membrane
fusion.
concept
presents
promising
avenue
enhancing
control
over
thereby
therapeutic
concurrently
mitigating
toxic
side
effects
ultimately
facilitating
realization
precision
medicine.In
this
Account,
we
present
comprehensive
overview
our
recent
research
advancements
field
cells.
Our
work
involves
application
biological
engineering
manipulate
endogenous
therapeutics
drug
instance,
avoid
laborious
process
isolating,
modifying,
expanding
Язык: Английский
Nano-Based Strategies Aiming at Tumor Microenvironment for Improved Cancer Therapy
Molecular Pharmaceutics,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 17, 2025
Malignant
tumors
pose
a
considerable
threat
to
human
life
and
health.
Traditional
treatments,
such
as
radiotherapy
chemotherapy,
often
lack
specificity,
leading
collateral
damage
normal
tissues.
Tumor
microenvironment
(TME)
is
characterized
by
hypoxia,
acidity,
redox
imbalances,
elevated
ATP
levels
factors
that
collectively
promote
tumor
growth
metastasis.
This
review
provides
comprehensive
overview
of
the
nanoparticles
developed
in
recent
years
for
TME-responsive
strategies
or
TME-modulating
methods
therapy.
The
focus
on
designing
synthesizing
can
interact
with
achieve
precisely
controlled
drug
release.
These
activate
release
under
specific
conditions
within
environment,
thereby
enhancing
efficacy
drugs
while
reducing
toxicity
cells.
Moreover,
simply
eliminating
cells
does
not
fundamentally
solve
problem.
Only
comprehensively
regulating
TME
make
it
unsuitable
cell
survival
proliferation
we
more
thorough
therapeutic
effects
reduce
risk
recurrence.
regulation
aim
suppress
metastasis
modulating
various
components
TME.
only
improve
treatment
outcomes
but
also
have
potential
lay
foundation
future
personalized
cancer
therapies.
Язык: Английский
Dual mRNA nanoparticles strategy for enhanced pancreatic cancer treatment and β-elemene combination therapy
Proceedings of the National Academy of Sciences,
Год журнала:
2025,
Номер
122(11)
Опубликована: Март 11, 2025
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
notoriously
immune-resistant,
limiting
the
clinical
efficacy
of
single-agent
immune
modulators
and
thereby
necessitating
exploration
multimodal
immunotherapy
combinations.
Traditional
approaches
combining
conventional
checkpoint
inhibitors
with
neoantigen
vaccines
have
shown
some
promise
in
treating
PDAC
but
are
often
compromised
by
intratumoral
T
lymphocyte
exhaustion
systemic
toxicity.
Hence,
novel
needed
to
address
these
challenges.
Herein,
we
demonstrate
that
mRNA
polymeric
nanoparticles
encoding
anti-PD-1
antibodies
situ
at
tumor
site
enhance
therapeutic
neoantigen-based
vaccine
for
PDAC.
This
mRNA-based,
antibody
production
strategy
also
protects
tumor-infiltrating
cells
from
PD-1
inhibition,
potentially
reducing
toxicities
induced
inhibition.
Our
study
may
provide
an
innovative
dual
nanoparticle
effective
immunotherapy,
as
well
cancer
combination
therapy
other
clinically
approved
drugs
(e.g.,
β-elemene).
Язык: Английский
Extensive Review of Nanomedicine Strategies Targeting the Tumor Microenvironment in PDAC
Xing Liu,
Yidan Shao,
Yunjiang Li
и другие.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 3379 - 3406
Опубликована: Март 1, 2025
Pancreatic
ductal
adenocarcinoma
(PDAC)
is
one
of
the
deadliest
cancers
in
world,
mainly
because
its
powerful
pro-connective
tissue
proliferation
matrix
and
immunosuppressive
tumor
microenvironment
(TME),
which
promote
progression
metastasis.
In
addition,
extracellular
leads
to
vascular
collapse,
increased
interstitial
fluid
pressure,
obstruction
lymphatic
return,
thereby
hindering
effective
drug
delivery,
deep
penetration,
immune
cell
infiltration.
Therefore,
reshaping
TME
enhance
perfusion,
increase
reverse
suppression
has
become
a
key
therapeutic
strategy.
Traditional
therapies
for
PDAC,
including
surgery,
radiation,
chemotherapy,
face
significant
limitations.
Surgery
challenging
due
location
growth,
while
chemotherapy
radiation
are
hindered
by
dense
TME.
recent
years,
advancement
nanotechnology
provided
new
opportunities
improve
efficacy.
Nanoscale
delivery
systems
(NDDSs)
provide
several
advantages,
improved
stability
vivo,
enhanced
reduced
systemic
toxicity.
However,
clinical
translation
PDAC
therapy
faces
challenges.
These
include
need
precise
targeting
control
over
release,
potential
responses
nanocarriers,
scalability
cost-effectiveness
production.
This
article
provides
an
overview
latest
nanobased
methods
achieving
better
outcomes
overcoming
resistance.
We
pay
special
attention
TME-targeted
context
discuss
advantages
limitations
current
strategies,
emphasize
promising
developments.
By
emphasizing
enormous
NDDSs
improving
treatment
patients
with
critically
discussing
traditional
challenges
faced
breakthroughs,
our
review
paves
way
future
research
this
rapidly
developing
field.
Язык: Английский
Pancreatic cancer: failures and hopes—a review of new promising treatment approaches
Exploration of Targeted Anti-tumor Therapy,
Год журнала:
2025,
Номер
6
Опубликована: Март 18, 2025
Pancreatic
cancer
is
a
challenging
disease
with
limited
treatment
options
and
high
mortality
rate.
Just
few
therapy
advances
have
been
made
in
recent
years.
Tumor
microenvironment,
immunosuppressive
features
mutational
status
represent
important
obstacles
the
improvement
of
survival
outcomes.
Up
to
now,
first-line
did
achieve
median
overall
less
than
12
months
this
discouraging
data
lead
clinicians
all
over
world
focus
their
efforts
on
various
fields
investigation:
1)
sequential
cycling
different
systemic
order
overcome
mechanisms
resistance;
2)
discovery
new
predictive
bio-markers,
target
specific
patient
population;
3)
combination
treatment,
modulate
tumor
microenvironment
pancreatic
cancer;
4)
modalities
delivery
drugs
pass
physical
barrier
desmoplasia
stroma.
This
review
shows
future
directions
strategies
advanced
through
deep
analysis
these
macro
areas
research.
Язык: Английский
A single-cell perspective on immunotherapy for pancreatic cancer: from microenvironment analysis to therapeutic strategy innovation
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Окт. 30, 2024
Pancreatic
cancer
remains
one
of
the
most
lethal
malignancies,
with
conventional
treatment
options
providing
limited
efficacy.
Recent
advancements
in
immunotherapy
have
offered
new
hope,
yet
unique
tumor
microenvironment
(TME)
pancreatic
poses
significant
challenges
to
its
successful
application.
This
review
explores
transformative
impact
single-cell
technology
on
understanding
and
cancer.
By
enabling
high-resolution
analysis
cellular
heterogeneity
within
TME,
approaches
elucidated
complex
interplay
between
various
immune
cell
populations.
These
insights
led
identification
predictive
biomarkers
development
innovative,
personalized
immunotherapeutic
strategies.
The
discusses
role
dissecting
intricate
landscape
cancer,
highlighting
discovery
T
exhaustion
profiles
macrophage
polarization
states
that
influence
response.
Moreover,
it
outlines
potential
data
guiding
selection
drugs
optimizing
plans.
also
addresses
prospects
translating
these
single-cell-based
innovations
into
clinical
practice,
emphasizing
need
for
interdisciplinary
research
integration
artificial
intelligence
overcome
current
limitations.
Ultimately,
underscores
promise
driving
therapeutic
strategy
innovation
improving
patient
outcomes
battle
against
Язык: Английский
The Multifaced Role of Collagen in Cancer Development and Progression
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(24), С. 13523 - 13523
Опубликована: Дек. 17, 2024
Collagen
is
a
crucial
protein
in
the
extracellular
matrix
(ECM)
essential
for
preserving
tissue
architecture
and
supporting
cellular
functions
like
proliferation
differentiation.
There
are
twenty-eight
identified
types
of
collagen,
which
further
divided
into
different
subgroups.
This
plays
critical
role
regulating
homeostasis.
However,
solid
tumors,
balance
can
be
disrupted,
due
to
an
abundance
collagen
tumor
microenvironment,
significantly
affects
growth,
cell
invasion,
metastasis.
It
important
investigate
specific
collagens
cancer
ECM
their
distinct
roles
progression
comprehend
unique
contribution
behavior.
The
diverse
pathophysiological
cancers
illustrate
collagen’s
dual
roles,
offering
potential
therapeutic
options
serving
as
prognostic
markers.
Язык: Английский