Ageing Research Reviews, Год журнала: 2024, Номер unknown, С. 102544 - 102544
Опубликована: Окт. 1, 2024
Язык: Английский
Food Chemistry Advances, Год журнала: 2025, Номер 6, С. 100919 - 100919
Опубликована: Фев. 11, 2025
Язык: Английский
Процитировано
4
Cellular and Molecular Life Sciences, Год журнала: 2024, Номер 81(1)
Опубликована: Окт. 30, 2024
Язык: Английский
Процитировано
9
Pathogens, Год журнала: 2025, Номер 14(2), С. 111 - 111
Опубликована: Янв. 23, 2025
Dental caries is the most common oral disease in world and a chronic infectious disease. The cariogenic microbiome plays an important role process of caries. ecological imbalance microbiota leads to low pH, which causes Therefore, antibacterial materials have always been hot topic. Traditional such as cationic agents, metal ion some natural extract agents good effects. However, they can cause bacterial resistance poor biological safety when used for long-term purposes. Intelligent materials, pH-responsive nanozymes, photoresponsive piezoelectric living are emerging nano-strategies that respond microenvironment or other specific stimuli exert Compared with traditional these less prone resistanceand safety. This review summarizes characteristics materials. These accurately act on microenvironment, showing intelligent effects providing new ideas management.
Язык: Английский
Процитировано
1
Journal of Experimental & Clinical Cancer Research, Год журнала: 2025, Номер 44(1)
Опубликована: Фев. 7, 2025
Abstract The gut microbiota plays a crucial role in safeguarding host health and driving the progression of intestinal diseases. Despite recent advances remarkable correlation between dysbiosis extraintestinal cancers, underlying mechanisms are yet to be fully elucidated. Pathogenic microbiota, along with their metabolites, can undermine integrity barrier through inflammatory or metabolic pathways, leading increased permeability translocation pathogens. dissemination pathogens circulation may contribute establishment an immune-suppressive environment that promotes carcinogenesis organs either directly indirectly. oncogenic cascade always engages disruption hormonal regulation responses, induction genomic instability mutations, dysregulation adult stem cell proliferation. This review aims comprehensively summarize existing evidence points potential malignant transformation such as liver, breast, lung, pancreas. Additionally, we delve into limitations inherent current methodologies, particularly challenges associated differentiating low loads gut-derived microbiome within tumors from sample contamination symbiotic microorganisms. Although still controversial, understanding contribution translocated metabolites pathological continuum chronic inflammation could offer novel foundation for development targeted therapeutics.
Язык: Английский
Процитировано
1
Inflammopharmacology, Год журнала: 2024, Номер 32(5), С. 2753 - 2779
Опубликована: Авг. 19, 2024
Язык: Английский
Процитировано
6
MEDICINUS, Год журнала: 2025, Номер 38(1), С. 27 - 36
Опубликована: Янв. 1, 2025
Proses penemuan obat telah memasuki era baru dengan munculnya kecerdasan buatan (artificial intelligence/AI) dan big data. Pendekatan tradisional, panjang, mahal kini dilengkapi alternatif yang efisien berkat kemampuan AI untuk menganalisis pola kompleks data mengintegrasikan kumpulan berskala besar. Artikel ini membahas peran teknologi tersebut dalam mempercepat inovasi farmasi, mengulas aplikasi praktis, menyoroti tantangan serta prospek masa depan. Dengan data, industri farmasi dapat memajukan pengobatan presisi memperdalam pemahaman kita tentang biologi penyakit.
Процитировано
0
Molecular & Cellular Toxicology, Год журнала: 2025, Номер unknown
Опубликована: Янв. 21, 2025
Язык: Английский
Процитировано
0
IGI Global eBooks, Год журнала: 2025, Номер unknown, С. 99 - 132
Опубликована: Янв. 31, 2025
Autism Spectrum Disorders (ASD) are neurodevelopmental conditions characterized by social communication challenges and repetitive behaviors. Emerging evidence suggests that gut microbiota, through the gut-brain axis, play a significant role in ASD pathogenesis. This complex network influences neurodevelopment modulating immune responses, producing neuroactive metabolites, maintaining barrier integrity. In individuals with ASD, specific microbial imbalances reduced diversity commonly observed, which linked to these pathophysiological processes. Genetic predispositions environmental factors, such as diet antibiotic use, further affect microbiota composition, potentially exacerbating imbalances. Therapeutic strategies targeting including probiotics, prebiotics, dietary modifications, fecal transplantation, have shown potential alleviating symptoms. chapter provides comprehensive overview of current understanding microbiota's ASD.
Язык: Английский
Процитировано
0
Frontiers in Microbiology, Год журнала: 2025, Номер 16
Опубликована: Фев. 3, 2025
The global crisis of antimicrobial resistance (AMR) is escalating due to the misuse and overuse antibiotics, slow development new therapies, rise multidrug-resistant (MDR) infections. Traditional antibiotic treatments face limitations, including resistance, disruption microbiota, adverse side effects, environmental impact, emphasizing urgent need for innovative alternative antibacterial strategies. This review critically examines naturally derived biopolymers with intrinsic (essential feature) properties as a sustainable, next-generation traditional antibiotics. These may address bacterial uniquely by disrupting membranes rather than cellular functions, potentially reducing microbiota interference. Through comparative analysis mechanisms applications antibiotics biopolymers, this highlights potential such AMR while supporting human health.
Язык: Английский
Процитировано
0
Engineering Microbiology, Год журнала: 2025, Номер unknown, С. 100191 - 100191
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0