ROS: A “booster” for chronic inflammation and tumor metastasis

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Год журнала: 2024, Номер 1879(6), С. 189175 - 189175

Опубликована: Авг. 31, 2024

Язык: Английский

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Inhibition of MMP-2 and MMP-9 by Dietary Antioxidants in THP-1 Macrophages and Sera from Patients with Breast Cancer

Molecules, Год журнала: 2024, Номер 29(8), С. 1718 - 1718

Опубликована: Апрель 10, 2024

Polyphenols, the main antioxidants of diet, have shown anti-inflammatory, antioxidant and anticarcinogenic activities. Here, we compared effects four polyphenolic compounds on ROS production levels matrix metalloproteinase (MMP)-2 -9, which represent important pathogenetic factors breast cancer. THP-1 differentiated macrophages were activated by LPS simultaneously treated with different doses a green tea extract (GTE), resveratrol (RSV), curcumin (CRC) an olive fruit (oliplus). By using 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, found that all tested showed activity in vitro. In addition, GTE, RSV CRC able to counteract induced H

Язык: Английский

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FeSA‐Ir/Metallene Nanozymes Induce Sequential Ferroptosis‐Pyroptosis for Multi‐Immunogenic Responses Against Lung Metastasis

Small, Год журнала: 2024, Номер unknown

Опубликована: Июнь 14, 2024

Abstract For cancer metastasis inhibition, the combining of nanozymes with immune checkpoint blockade (ICB) therapy remains major challenge in controllable reactive oxygen species (ROS) generation for creating effective immunogenicity. Herein, new light‐controlled ROS production terms quantity and variety are developed by conjugating supramolecular‐wrapped Fe single atom on iridium metallene lattice‐strained nanoislands (FeSA‐Ir@PF NSs). The Fenton‐like catalysis FeSA‐Ir@PF NSs effectively produced •OH radicals dark, which induced ferroptosis apoptosis cells. While under second near‐infrared (NIR‐II) light irradiation, showed ultrahigh photothermal conversion efficiency (𝜂, 75.29%), cooperative robust generation, photocatalytic O 2 1 caused significant pyroptosis sequential cells pyroptosis, led 99.1% primary tumor inhibition multi‐immunogenic responses vivo. Most importantly, lung is completely achieved inhibitors, as demonstrated different mice models, including circulating (CTCs) model. This work provided inspiration developing treatments inhibition.

Язык: Английский

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Elevated ROS Levels Caused by Reductions in GSH and AsA Contents Lead to Grain Yield Reduction in Qingke under Continuous Cropping

Plants, Год журнала: 2024, Номер 13(7), С. 1003 - 1003

Опубликована: Март 31, 2024

Continuous spring cropping of Qingke (

Язык: Английский

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Rational design of ROS generation nanosystems to regulate innate immunity of macrophages, dendrtical and natural killing cells for immunotherapy

International Immunopharmacology, Год журнала: 2024, Номер 139, С. 112695 - 112695

Опубликована: Июль 17, 2024

Язык: Английский

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Three‐Level Nanoparticle Rocket Strategy for Colorectal Cancer Therapeutics in Photothermal Therapy, Inflammation Modulation, and Cuproptosis Induction

Advanced Healthcare Materials, Год журнала: 2025, Номер unknown

Опубликована: Янв. 10, 2025

Abstract Disturbances in intracellular copper (Cu) homeostasis can trigger cuproptosis, a new form of cell death, which, when combined with photothermal therapy (PTT), offers promising solution to the persistent challenges colorectal cancer (CRC) treatment. In this study, “three‐level nanoparticle rocket” strategy is developed by engineering Cu 5.4 O, multifunctional Cu‐based nanoenzyme that and has electron transfer properties antioxidant efficiency. O effectively remodels inflammatory environment scavenging reactive oxygen species, thereby overcoming traditional limitations PTT. Concurrently, releases substantial amounts + into malignant cells, disrupting homeostasis, inducing ultimately inhibiting tumor progression. vivo vitro experiments demonstrate operates through multiple successive interlocking stages significantly eradicate tumors, prevent relapse, prolong survival. This study provides profound insights synergistic effects PTT, regulation, cuproptosis within complex microenvironment, presenting innovative approaches for future CRC therapy.

Язык: Английский

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Kushenol O Regulates GALNT7/NF-κB axis-Mediated M2 Macrophage Polarization and Efferocytosis in Papillary Thyroid Carcinoma

Phytomedicine, Год журнала: 2025, Номер 138, С. 156373 - 156373

Опубликована: Янв. 14, 2025

Язык: Английский

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Targeting Nanotherapeutics for Highly Efficient Diagnosis and Treatment of Systemic Lupus Erythematosus through Regulation of Immune Response

Small Science, Год журнала: 2025, Номер unknown

Опубликована: Янв. 23, 2025

Systemic lupus erythematosus (SLE) is characterized by the production of pathogenic autoantibodies, particularly antidouble‐stranded (ds) DNA antibodies, which contribute to multiorgan damage (lupus nephritis, LN). Hence, there an urgent need recognize and eliminate SLE‐specific anti‐ds antibodies enhance SLE treatment. Herein, mesoporous silica (MSNs) loaded with SeC surface‐modified ctDNA are constructed effectively specific bind anti‐dsDNA for treatment in 125 plasm enabling swift LN diagnosis 36 kidney tissue from patients. As expected, clearance ratio nanotherapeutics significantly greater compared other products commonly used clinical therapies exhibits biocompatibility safety Moreover, MSNs‐DNA can also help visualize distribution lesions kidney. Importantly, combination strategy (MSNs‐DNA@SeC) remove reduce UP regulation B cells T female MRL/lpr model mice alleviate related symptoms. Collectively, resultant data not only presents a straightforward method systematic design nanomedicine targeting effects on treatment, but elucidates potential mechanisms involving pathogenesis progression SLE.

Язык: Английский

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Harnessing Akkermansia muciniphila Membrane Coating for Probiotic Therapy in Inflammatory Bowel Disease

ACS Applied Materials & Interfaces, Год журнала: 2025, Номер unknown

Опубликована: Фев. 17, 2025

Inflammatory bowel diseases (IBDs) are characterized by dysregulated inflammatory responses, increased reactive oxygen species (ROS), and compromised intestinal barrier function. Current clinical treatments often yield suboptimal responses significant side effects. Given the great potential of Akkermansia muciniphila (AKK) bacterial membrane components in IBD treatment possible pathogenicity live bacteria, to essentially address these challenges, we develop a natural membrane-based single-cell coating, incorporating self-assembled AKK (AKM) astaxanthin (AST), forming protective biological on probiotics. Utilizing Escherichia coli Nissle 1917 (EcN) for oral delivery system, engineer AKM-AST@EcN nanocoated probiotics, demonstrating exceptional gastrointestinal (GI) tract tolerance robust bioactivity. Critically, our findings highlight as promising therapeutic approach while also presenting distinctive strategy probiotic systems.

Язык: Английский

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Chemical modulation of the tumor microenvironment enabled by nanomaterials for enhanced cancer treatment

Cell Reports Physical Science, Год журнала: 2025, Номер unknown, С. 102452 - 102452

Опубликована: Фев. 1, 2025

Язык: Английский

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