Briefings in Bioinformatics,
Год журнала:
2024,
Номер
26(1)
Опубликована: Ноя. 22, 2024
Abstract
Artificial
intelligence
(AI)-based
multi-modal
fusion
algorithms
are
pivotal
in
emulating
clinical
practice
by
integrating
data
from
diverse
sources.
However,
most
of
the
existing
models
focus
on
designing
new
modal
methods,
ignoring
critical
role
feature
representation.
Enhancing
representativeness
can
address
noise
caused
heterogeneity
at
source,
enabling
high
performance
even
with
small
datasets
and
simple
architectures.
Here,
we
introduce
DeepOmix-FLEX
(Fusion
Learning
Enhanced
representation
for
X-modal
or
FLEX
short),
a
model
that
integrates
data,
proteomic
metabolomic
pathology
images
across
different
scales
modalities,
advanced
learning
contains
Feature
Encoding
Trainer
structure
train
encoding,
thus
achieving
inter-feature
inter-modal.
achieves
mean
AUC
0.887
prediction
chronic
kidney
disease
progression
an
internal
dataset,
exceeding
0.727
using
conventional
variables.
Following
external
validation
interpretability
analyses,
our
demonstrated
favorable
generalizability
validity,
as
well
ability
to
exploit
markers.
In
summary,
highlights
potential
AI
integrate
optimize
allocation
healthcare
resources
through
accurate
prediction.
Diabetes Obesity and Metabolism,
Год журнала:
2022,
Номер
24(7), С. 1277 - 1287
Опубликована: Март 24, 2022
To
examine
how
the
development
of
cardiovascular
and
renal
disease
(CVRD)
translates
to
hospital
healthcare
costs
in
individuals
with
type
2
diabetes
(T2D)
initially
free
from
CVRD.
Metabolism,
Год журнала:
2025,
Номер
unknown, С. 156157 - 156157
Опубликована: Фев. 1, 2025
Highlights•MSDC-0602K
differentially
affects
BM-MSCs
and
AT-MSCs.•Bioorthogonal
click
chemistry
allowed
measurement
of
pyruvate
pools.•Subcellular
metabolic
flux
analysis
revealed
rewiring
pathways.•Metabolic
TG
synthesis
showed
distinct
adipogenic
strategies.AbstractObjectiveInsulin-sensitizing
drugs,
despite
their
broad
use
against
type
2
diabetes,
can
adversely
affect
bone
health,
the
mechanisms
underlying
these
side
effects
remain
largely
unclear.
Here,
we
investigated
different
a
series
thiazolidinediones,
including
rosiglitazone,
pioglitazone,
second-generation
compound
MSDC-0602
K,
on
human
mesenchymal
stem
cells
(MSCs).MethodsWe
developed
13C
subcellular
metabolomic
tracer
measuring
separate
mitochondrial
cytosolic
metabolite
pools,
lipidomic
network-based
isotopologue
models,
bioorthogonal
chemistry,
to
demonstrate
that
K
affected
marrow-derived
MSCs
(BM-MSCs)
adipose
tissue-derived
(AT-MSCs).
In
BM-MSCs,
promoted
osteoblastic
differentiation
suppressed
adipogenesis.
This
effect
was
clearly
from
earlier
drugs
AT-MSCs.ResultsFluxomic
data
reveal
unexpected
differences
between
this
drug's
provide
mechanistic
insight
into
pharmacologic
inhibition
carrier
1
(MPC).
Our
study
demonstrates
retains
capacity
inhibit
MPC,
akin
rosiglitazone
but
unlike
enabling
utilization
alternative
pathways.
Notably,
exhibits
limited
lipogenic
potential
compared
both
each
which
employs
strategy.ConclusionsThese
findings
indicate
new-generation
do
not
compromise
structure,
offering
safer
for
treating
insulin
resistance.
Moreover,
results
highlight
ability
cell
compartment-specific
labeling
by
reactions
metabolomics
complex
lipids
discover
molecular
within
intersection
carbohydrate
lipid
metabolism.Graphical
abstract
Abstract
According
to
traditional
Chinese
medicine
(TCM)
constitutional
theory,
individuals
with
phlegm-dampness
constitution
(PDC)
are
at
increased
risk
for
metabolic
disorders.
Previous
studies
have
indicated
that
PDC
exhibit
gene
expression
changes
associated
disorders,
even
normal
indices.
However,
the
biological
mechanisms
underlying
these
remain
unclear.
The
gut
microbiota
has
recently
emerged
as
a
promising
avenue
elucidating
TCM
principles.
Here,
we
revealed
distinct
and
serum
metabolite
profiles.
A
decrease
in
phytosphingosine
was
scores
disorder
severity.
Subsequent
experiments
demonstrated
Flavonifractor
plautii
can
biosynthesize
phytosphingosine,
which
also
negatively
correlated
score.
Interestingly,
both
F.
levels
decreased
subjects
Fecal
transplantation
from
accelerated
development
of
disorders
mice.
supplementation
ameliorated
by
increasing
gut‒hepatic
axis.
Mechanistic
investigations
confirmed
directly
bind
hepatic
peroxisome
proliferator-activated
receptor
α
(PPARα)
activate
its
nuclear
transcription
activity,
thereby
regulating
downstream
related
glucose‒lipid
metabolism.
Our
research
indicates
product,
contributes
increases
their
susceptibility
These
findings
suggest
diagnosing
may
be
beneficial
identifying
at-risk
populations
among
apparently
healthy
individuals,
advancing
broader
field
prevention
integration.
Expert Review of Medical Devices,
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 4, 2025
Diabetes
is
a
chronic
disease
with
high
prevalence,
necessitating
advanced
technology
to
achieve
glycemic
targets
and
reduce
complications.
Continuous
glucose
monitoring
(CGM)
has
become
cornerstone
in
diabetes
management,
the
Freestyle
Libre
(FSL)
systems
being
some
of
most
widely
used
devices.
This
review
focuses
on
FSL
systems,
each
including
an
all-in-one
sensor
transmitter,
handheld
reader
Mobile
Medical
App
(MMA).
Glucose
data
are
uploaded
dedicated
cloud-based
platform
for
analysis.
Over
years,
evolved
new
features
offering
valuable
support
individuals
diabetes,
caregivers,
healthcare
providers.
Clinical
trials
real-world
studies
have
demonstrated
efficacy
safety
across
diverse
populations,
type
1
2
adolescents,
pregnant
women
diabetes.
user-friendly
system
that
meets
needs
patients
health
care
The
MMA
allows
metrics
pattern
identification,
supports
educational
strategies
patient-tailored
treatment.
Future
advancements,
ketone
monitoring,
integration
wearable
other
devices,
telemedicine
applications,
will
further
optimize
prevention.
Frontiers in Cardiovascular Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 8, 2025
Cardio-kidney
metabolic
(CKM)
syndrome
represents
a
complex
and
circular
interplay
of
cardiovascular,
renal,
dysfunctions,
significantly
contributing
to
global
morbidity
mortality.
This
expert
opinion
synthesizes
insights
from
panel
Italian
specialists
in
cardiology,
nephrology,
diabetology,
advocating
for
holistic
integrated
framework
CKM
management.
The
recommendations
underline
the
critical
need
early
identification
stratification
stages,
fostering
an
interdisciplinary
approach
that
bridges
specialties
ensures
comprehensive
care.
Emphasizing
innovative
pathways
collaboration,
including
dynamic
referral
protocols,
telemedicine,
shared
decision-making,
proposed
strategies
aim
overcome
structural
organizational
barriers
healthcare.
By
promoting
unified
approach,
seeks
streamline
care,
enhance
communication
among
specialists,
improve
coordination
services.
strategy
pivotal
step
toward
mitigating
disease
progression,
improving
clinical
outcomes,
enhancing
quality
life
patients
with
syndrome.
