The Asian Pacific association for the study of the liver clinical practice guidelines for the diagnosis and management of metabolic dysfunction-associated fatty liver disease

Hepatology International, Год журнала: 2025, Номер unknown

Опубликована: Фев. 27, 2025

Язык: Английский

---

Submicron Dispersions of Phytosterols Reverse Liver Steatosis with Higher Efficacy than Phytosterol Esters in a Diet Induced-Fatty Liver Murine Model

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(2), С. 564 - 564

Опубликована: Янв. 10, 2025

Consumption of phytosterols is a nutritional strategy employed to reduce cholesterol absorption, but recent research shows that their biological activity might go beyond reduction for the treatment metabolic dysfunction-associated fatty liver disease (MAFLD), and novel phytosterol formulations, such as submicron dispersions, could improve these effects. We explored therapeutic phytosterols, either formulated dispersions (SDPs) or conventional esters (PEs), in mouse model MAFLD. MAFLD was induced mice by atherogenic diet (AD) feeding. The reversion distorted serum parameter values after period AD feeding investigated supplementation with SDPs, PEs, placebo (PT). Additionally, parameters acid synthesis, oxidation, inflammation were studied understand mechanism action phytosterols. SDPs shown fat, along showing significant improvement triglycerides (TGs), free acids (FFAs), levels. These results reinforced analyses steatosis scores, histologies, where SDP intervention showed consistent improvement. Treatment PEs slighter effects same analyses, no observed PT treatment. reversed, higher efficacy than effect on levels TGs, total- LDL-cholesterol levels, glucose And, exceptionally, while improved HDL-cholesterol did not show any this parameter. provide evidence therapeutical regulation which increased when are compared ester formulations.

Язык: Английский

---

Evaluating Bioactive-Substance-Based Interventions for Adults with MASLD: Results from a Systematic Scoping Review

Nutrients, Год журнала: 2025, Номер 17(3), С. 453 - 453

Опубликована: Янв. 26, 2025

Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a chronic condition affecting broad population. This review aimed to identify and summarize the current evidence on bioactive-substance-based interventions for adults with MASLD, formerly known as nonalcoholic fatty (NAFLD), covering publications from 2000 2023. Methods: A search was conducted across six databases (MEDLINE, CINAHL, Cochrane CENTRAL, Database of Systematic Reviews, Food Science Source, SPORTDiscus) randomized controlled trials other study types (e.g., prospective cohort studies systematic reviews), reflecting scoping nature this review. The limited in (>18 years old), an intervention interest at least one comparator group. Results: total 4572 articles were retrieved, 201 full-text screened eligibility. Of these, 131 primary 49 reviews included most studied bioactive substances Curcumin (Turmeric) (n = 25), Silymarin (Milk Thistle) 17), Resveratrol 10), Coffee 7), Green Tea 5), Berberine 5 each). Moreover, 46 reported 36 2 or fewer each. Among reviews, 13 focused Curcumin, 12 Tea, 10 substance combinations, 6 Resveratrol, each Artichoke Leaf. showed substantial heterogeneity outcomes, which primarily hepatic health, body weight, adverse events, glycemic control, blood lipids, composition. Conclusions: highlights range used treatment MASLD. While abundant like Silymarin, further research synthesis findings necessary establish clinical efficacy all substances.

Язык: Английский

---

Fructose Intake and Unhealthy Eating Habits Are Associated with MASLD in Pediatric Obesity: A Cross-Sectional Pilot Study

Nutrients, Год журнала: 2025, Номер 17(4), С. 631 - 631

Опубликована: Фев. 10, 2025

Background/Objectives: Fructose consumption in children is increasing, as the prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD). Despite evidence linking added sugars to syndrome, fructose's impact on youth remains unclear, especially pediatrics. Our study aimed evaluate role fructose intake and dysfunction a cohort pre-school adolescents with obesity. Methods: We recruited 41 obesity (age range: 2.5-16 years, BMI SDS 2.6 ± 0.5 kg/m2). Clinical biochemical parameters were assessed. Through ultrasound (US), MASLD, hepatorenal index (HRI), subcutaneous adipose tissue (scAT), visceral (vAT) Dietary was evaluated using IDEFICS FFQ fructose-specific questionnaire. Results: Pubertal subjects had more scAT vAT, higher insulin resistance, fibrosis than those prepubertal. MASLD detected 12 subjects, associated vAT. lower weekly prepubertal (p < 0.02). However, they consumed less from fruits 0.04) other younger children. Patients reported 0.01), primarily 0.003), likely due misreporting, alongside unhealthy food, mainly rich saturated fats. Conclusions: dietary habits Advice pay attention foods fats mandatory decrease both MASLD. Further high-powered studies any pediatric age different geographical areas are needed better history.

Язык: Английский

---

Mitochondrial targeted therapy in MAFLD

Biochemical and Biophysical Research Communications, Год журнала: 2025, Номер 753, С. 151498 - 151498

Опубликована: Фев. 17, 2025

Язык: Английский

---

Noninvasive tests and diagnostic pathways to MASH diagnosis in the United States: a retrospective observational study

Journal of Medical Economics, Год журнала: 2025, Номер unknown, С. 1 - 12

Опубликована: Фев. 18, 2025

Aim Although liver biopsy is considered the most reliable diagnostic tool for metabolic dysfunction–associated steatohepatitis (MASH), it invasive and can be costly. Clinicians are increasingly relying on routine biomarkers other noninvasive tests (NITs) diagnosis. We examined real-world pathways patients newly diagnosed with MASH a primary focus NITs.

Язык: Английский

---

Macauba (Acrocomia ssp.) fruits: A comprehensive review of nutritional and phytochemical profiles, health benefits, and sustainable oil production

Comprehensive Reviews in Food Science and Food Safety, Год журнала: 2025, Номер 24(1)

Опубликована: Янв. 1, 2025

Abstract Macauba is an underexplored palm with significant potential for food‐grade vegetable oil production. Its fruits yield two distinct sources of oil, the pulp and kernel, each its unique composition, emerging as a source high competitiveness well‐established conventional sources. Besides macauba are rich in essential nutrients, including proteins, minerals, vitamins, dietary fiber, phytochemicals, outstanding health benefits. processing generates valuable co‐products, epicarp, kernel cakes, endocarp, which have considerable enhancing production chain. This review explores nutritional phytochemical profile macauba, benefits, exploiting co‐products. Innovative extraction methods comprehensive strategy producing multiple products from co‐products also highlighted opportunities to achieve sustainable development goals circular economy fruit processing.

Язык: Английский

---

Web of Science‐Based Visualization of Metabolic Dysfunction‐Associated Fatty Liver Disease in Pediatric and Adolescent Populations: A Bibliometric Study

Health Science Reports, Год журнала: 2025, Номер 8(2)

Опубликована: Янв. 29, 2025

ABSTRACT Background and Aims The prevalence of metabolism‐associated fatty liver disease (MAFLD) in children is on the rise. This study employs visualization analysis to evaluate research implications, current advancements, emerging trends pediatric MAFLD, with aim elucidating its pathogenesis informing development clinical treatment strategies. Methods Using software, we conducted a visual mapping journal distribution, leading institutions, prominent authors, annual publication trends, keyword frequencies among 1179 scholarly articles retrieved from Web Science Core Collection for this study. Results overall volume demonstrated an upward trend, total 200 journals, contributions 63 countries, 882 5605 authors involved, including 84 who were identified as core authors. main team led by Nobili, Valerio. institutions are concentrated Italy, United States, China. A 473 keywords included, high frequency medium centricity insulin resistance, metabolic syndrome, children, steatohepatitis, adolescents, hepatic steatosis, nash, obesity, diagnosis, fibrosis, which resulted six clusters. Conclusion MAFLD represents significant public health concern. Research adolescents continues attract interest. Noninvasive diagnostic methods, (intestinal microbiota research), prediction (gene research) hotspots.

Язык: Английский

---

Metabolite Signatures and Their Mediation Effects on the Relationship Between Mediterranean Diet Adherence and MASLD Progression

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Фев. 18, 2025

Background Mediterranean Diet (MED) is recommended for managing patients with Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD). However, the potential metabolic changes involved in this relationship remain unclear. This study aims to investigate how biomarkers mediate association between MED adherence and liver-related events (LRE) mortality MASLD.Methods We performed a prospective analysis using UK Biobank data, including 47,429 MASLD participants free of LRE at baseline. was assessed as alternate (aMED) score through validated questionnaire covering 206 foods 32 beverages. were measured high-throughput nucleic magnetic resonance (NMR) spectroscopy. Cox regression restricted cubic splines aMED, its components, risk mortality. Mediation evaluated role metabolites progression.Results Over median follow-up 13.3 years, 296 cases 3,616 deaths occurred. Higher aMED scores (6–9) associated lower risks (HR: 0.553, 95% CI: 0.351–0.874) 0.854, 0.762–0.956) compared lowest (0–3). Linear dose-response relationships observed both incidence (P_nonlinear = 0.91) 0.07). Certain vegetables legumes, reduced LRE, while vegetables, nuts, fish, MUFA:SFA ratio, moderate alcohol intake linked risk. Of 143 metabolites, 46 significantly aMED. Positive associations included very large HDL particles (n 3), unsaturated fatty acids 8), albumin, acetate, negative found VLDL 11), small middle 13), saturated 2), Apo-AI, creatinine. Five aMED-related lipid negatively five positively revealed that omega-3 acids, total acid albumin accounted 7.9%, 11.9%, 2.6% reduction 19.4%, 23.1%, 4.7% mitigation mortality, respectively.Conclusions Adherence patients. such may mitigate progression.

Язык: Английский

---

Adherence to the planetary health diet index and metabolic dysfunction-associated steatotic liver disease: a cross-sectional study

Frontiers in Nutrition, Год журнала: 2025, Номер 12

Опубликована: Фев. 20, 2025

Adherence to the Planetary Health Diet Index (PHDI) has been shown benefit both individual health and planet. However, its impact on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) remains unclear. This study aimed investigate relationship between PHDI adherence MASLD risk. We analyzed a cohort of 15,865 adults (aged ≥18 years) using data from National Nutrition Examination Survey (NHANES, 2005-2018). The was derived 24-h dietary assessments comprised scores 15 food groups. Multivariate logistic regression used association MASLD, while restricted cubic spline (RCS) threshold analysis were employed explore potential non-linear relationship. Subgroup analyses conducted assess influence various demographic clinical characteristics observed associations. Mediation performed evaluate indirect effect weighted quantile sum (WQS) nutrients MASLD. Among cohort, 6,125 individuals diagnosed with revealed that higher quintile significantly associated reduced risk in fully adjusted model (OR = 0.610, 95%CI 0.508-0.733, p < 0.001). Notably, nonlinear relationships through RCS (p 0.002). indicated particularly effective reducing among females, those education attainment, living partner. WQS identified saturated fatty acids as most significant factor contributing (weight 0.313). Additionally, BMI waist circumference (81.47 87.66%, respectively) partially mediated risk, suggesting operates, part, circumference. remained robust across multiple sensitivity analyses. Our findings indicate is linked lower providing crucial insights for strategies at mitigating epidemic simultaneously fostering environmental sustainability.

Язык: Английский

---