Springer eBooks, Год журнала: 2024, Номер unknown, С. 3 - 13
Опубликована: Янв. 1, 2024
Springer eBooks, Год журнала: 2024, Номер unknown, С. 3 - 13
Опубликована: Янв. 1, 2024
Cell, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
The factors shaping human microbiome variation are a major focus of biomedical research. While other fields have used large sequencing compendia to extract insights requiring otherwise impractical sample sizes, the field has lacked comparably sized resource for 16S rRNA gene amplicon commonly quantify composition. To address this gap, we processed 168,464 publicly available gut samples with uniform pipeline. We use compendium evaluate geographic and technical effects on variation. find that regions such as Central Southern Asia differ significantly from more thoroughly characterized microbiomes Europe Northern America composition alone can be predict sample's region origin. also strong associations between primers DNA extraction. anticipate growing work, Human Microbiome Compendium, will enable advanced applied methodological
Язык: Английский
Процитировано
7Gut, Год журнала: 2024, Номер 73(11), С. 1909 - 1920
Опубликована: Июль 13, 2024
The gut microbiome has been recognised as a key component in the pathogenesis of inflammatory bowel diseases (IBD), and wide range metabolites produced by bacteria are an important mechanism which human interacts with host immunity or metabolism. High-throughput metabolomic profiling novel computational approaches now allow for comprehensive assessment thousands diverse biomaterials, including faecal samples. Several groups metabolites, short-chain fatty acids, tryptophan bile have associated IBD. In this
Язык: Английский
Процитировано
13International Journal of Molecular Sciences, Год журнала: 2024, Номер 25(16), С. 9118 - 9118
Опубликована: Авг. 22, 2024
The intricate interplay between the gut microbiota and polyphenols has emerged as a captivating frontier in understanding potentially harnessing therapeutic potential of these bioactive compounds. Phenolic compounds, renowned for their antioxidant, anti-inflammatory, antidiabetic, anticancer properties, are subject to transformations within milieu, where diverse microbial ecosystem exerts profound effects on metabolism bioavailability. Conversely, exhibit remarkable capacity modulate composition activity microbiota, fostering bidirectional relationship that extends beyond mere nutrient processing. This symbiotic interaction holds significant implications human health, particularly cardiometabolic diseases such diabetes mellitus, metabolic-dysfunction-associated steatotic liver disease, cardiovascular disease. Through comprehensive exploration molecular interactions, this narrative review elucidates reciprocal dynamics polyphenols, unveiling novel avenues intervention disorders. By unravelling cross-talk two entities, underscores multifaceted roles overall health pivotal role modulation promising strategy mitigating burden diseases.
Язык: Английский
Процитировано
13Trends in Microbiology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
2Frontiers in Immunology, Год журнала: 2024, Номер 15
Опубликована: Май 16, 2024
Importance Research is beginning to elucidate the sophisticated mechanisms underlying microbiota-gut-brain-immune interface, moving from primarily animal models human studies. Findings support dynamic relationships between gut microbiota as an ecosystem (microbiome) within (host) and its intersection with host immune nervous systems. Adding this effects on epigenetic regulation of gene expression further complicates strengthens response. At heart inflammation, which manifests in a variety pathologies including neurodegenerative diseases such Alzheimer’s disease, Parkinson’s Multiple Sclerosis (MS). Observations Generally, research date limited has focused bacteria, likely due simplicity cost-effectiveness 16s rRNA sequencing, despite lower resolution inability determine functional ability/alterations. However, omits all other fungi, viruses, phages, are emerging key members microbiome. Much been done pre-clinical and/or small studies more developed parts world. The observed promising but cannot be considered reliable or generalizable at time. Specifically, causal determined currently. More followed by then little MS. data for MS encouraging this. Conclusions relevance While still nascent, interface may missing link, hampered our progress understanding, let alone preventing, managing, putting into remission diseases. Relationships must first established humans, have shown poorly translate complex physiology environments, especially when investigating microbiome where often overly simplistic. Only can robust conducted humans using mechanistic model
Язык: Английский
Процитировано
9Biomolecules, Год журнала: 2025, Номер 15(5), С. 688 - 688
Опубликована: Май 8, 2025
Chronic inflammation plays a crucial role in cancer development, yet the mechanisms linking microbiome to inflammation-related carcinogenesis remain unclear. Emerging evidence suggests that microbiome-derived metabolites influence inflammatory pathways, presenting both challenges and opportunities for therapy. However, deeper understanding of how these regulate contribute prevention is still needed. This review explores recent advances their roles carcinogenesis. It highlights key molecular mechanisms, emerging therapies, unresolved challenges. Synthesizing current research, including clinical trials experimental models, bridges gap between science Microbial such as short-chain fatty acids (SCFAs), polyamines, indoles, bile play vital regulating suppressing cancer. Many exhibit potent anti-inflammatory immunomodulatory effects, demonstrating therapeutic potential. Case studies show promising results, but metabolite stability, bioavailability, individual variability remain. Understanding microbiome–metabolite interactions offers novel strategies treatment. identifies knowledge gaps proposes future research directions harness innovative therapies. Addressing issues may pave way microbiome-targeted interventions.
Язык: Английский
Процитировано
1Nature Reviews Microbiology, Год журнала: 2023, Номер 21(10), С. 624 - 625
Опубликована: Июнь 16, 2023
Язык: Английский
Процитировано
12Microbial Biotechnology, Год журнала: 2024, Номер 17(5)
Опубликована: Май 1, 2024
Abstract The human gut microbiome is a modifier of the risk for many non‐communicable diseases throughout lifespan. In ageing, effect appears to be more pronounced because lower physiological reserve. Microbial metabolites and other bioactive products act upon some key processes involved in Hallmarks Ageing. Dietary interventions that delay age‐related change have also led delayed onset ageing‐related health loss, improved levels cognitive function, inflammatory status frailty. Cross‐sectional analysis thousands datasets from around world has identified taxa are depleted during accelerated become abundant, but these signatures differ geographical regions. challenges research this area experimentally prove particular species or strains directly contribute health‐related ageing outcomes, develop practical ways retaining re‐administering them on population basis. promotion health‐associated mirrors challenge maintaining planetary microbial ecosystems face anthropogenic effects climate change. Lessons learned acting at individual level can inform microbiome‐targeting strategies achieving Sustainable Development Goals global level.
Язык: Английский
Процитировано
5Pediatric Research, Год журнала: 2025, Номер unknown
Опубликована: Фев. 28, 2025
Abstract The neonatal microbiome has been the focus of considerable research over past two decades and studies have added fascinating information in terms early microbial patterns how these relate to various disease processes. One difficulty with interpretation relationships is that such data associative provides little proof causality or underpinning mechanisms. Integrating other omics as proteome, inflammatory mediators, metabolome an emerging approach address this gap. Here we discuss omics, their integration, they can be applied improve our understanding, treatment, prevention disease. Impact This review introduces concept multiomics neonatology technologies integrated We highlight considerations for performing multiomic neonates need validation separate cohorts and/or relevant model systems. summarise use expanding lay out steps bring clinic enable precision medicine.
Язык: Английский
Процитировано
0Journal Of Advanced Pharmacy Education And Research, Год журнала: 2025, Номер 15(2), С. 16 - 30
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
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