Journal of Bacteriology, Год журнала: 2024, Номер unknown
Опубликована: Дек. 5, 2024
ABSTRACT Legionella pneumophila is an environmentally acquired pathogen that causes respiratory disease in humans. While the discovery of L. relatively recent compared to other bacterial pathogens, over past 50 years, has emerged as a powerhouse for studying host-pathogen interactions. In its natural habitat fresh water, interacts with diverse array protozoan hosts and readily evolve expand their host range. This led accumulation most extensive arsenal secreted virulence factors described ability infect Within amoebae human alveolar macrophages, bacteria replicate within specialized membrane-bound compartments, establishing model intracellular vacuolar pathogens. contrast, required replication are specifically tailored individual cells types, allowing adapt variation between disparate niches. The broad range this pathogen, combined diversity genome plasticity across genus, thus established bacterium archetype interrogate evolution, functional genomics, ecology. review, we highlight features establish them versatile organism, new paradigms bacteriology pathogenesis resulting from study , well current future questions will undoubtedly our understanding complex intricate biology microbial world.
Язык: Английский