Probiotic Potential of Yeast, Mold, and Intermediate Morphotypes of Geotrichum candidum in Modulating Gut Microbiota and Body Physiology in Mice
Probiotics and Antimicrobial Proteins,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 4, 2025
Язык: Английский
ANIDULAFUNGIN AND HUMAN MONOCYTES REDUCE Candida spp. BIOFILM WITH DIFFERENT FUNGAL BIOMASS.
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
ABSTRACT
Introduction
Candida
spp.
bloodstream
infection
is
a
frequent
form
of
mycosis
with
high
mortality
rates.
Biofilm
formation
potent
virulence
factor
for
albicans
and
parapsilosis
,
that
confers
significant
resistance
to
antifungal
agents
the
innate
immune
response.
Echinocandins
such
as
anidulafungin
are
new
drugs
broaden
available
therapeutic
arsenal
invasive
fungal
treatment.
Here
we
evaluated
effect
anidulafungin,
human-Monocytes
combined
treatment
on
mature
biofilms
clinical
isolates
different
intrinsic
capacity
biofilm,
biofilm
low
(LB)
biomass
(HB).
Methods
Yeasts
from
blood
were
molecularly
identified.
Lipase
acid
aspartic
protease
production,
adhesion
capacity,
ability
evaluated;
strains
classified
Weak,
Moderate
or
Strong
forming
capacity.
Mature
LB
HB
incubated
THP-1
cell
alone
exposed
both,
22
h.
Fungal
damage
induced
by
and/or
monocytes
was
determined
XTT[2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)
2H-tetrazolium-5-carboxanilide]
metabolic
assay.
Results
Our
results
showed
could
be
effective
reduce
most
C.
sensu
stricto
isolates,
independent
BF
strain.
Anidulafungin
in
combination
isolates.
Conclusions
The
effectiveness
ANF
seems
species
specific,
since
agent
exhibits
synergistic
activity
biofilm.
Язык: Английский
Biofilm-Associated Candidiasis: Pathogenesis, Prevalence, Challenges and Therapeutic Options
Pharmaceuticals,
Год журнала:
2025,
Номер
18(4), С. 460 - 460
Опубликована: Март 25, 2025
The
rising
prevalence
of
fungal
infections,
especially
those
caused
by
Candida
species,
presents
a
major
risk
to
global
health.
With
approximately
1.5
million
deaths
annually,
the
urgency
for
effective
treatment
options
has
never
been
greater.
spp.
are
leading
cause
invasive
significantly
impacting
immunocompromised
patients
and
in
healthcare
settings.
C.
albicans,
parapsilosis
emerging
species
auris
categorized
as
highly
dangerous
because
their
pathogenic
potential
increasing
drug
resistance.
This
review
comparatively
describes
formation
microbial
biofilms
both
bacterial
origin,
including
pathogens,
thereby
creating
novel
focus.
Biofilms
can
further
complicate
treatment,
these
structures
provide
enhanced
resistance
antifungal
therapies.
Traditional
agents,
polyenes,
azoles
echinocandins,
have
shown
effectiveness,
yet
development
continues
rise,
necessitating
exploration
therapeutic
approaches.
Antimicrobial
peptides
(AMPs)
such
anti-biofilm
Pom-1
Cm-p5
originally
isolated
from
snails
represent
promising
candidates
due
unique
mechanisms
action
neglectable
cytotoxicity.
article
discusses
challenges
posed
characteristics
important
role
virulence
new
like
AMPs.
Язык: Английский
Hostile Environments: Modifying Surfaces to Block Microbial Adhesion and Biofilm Formation
Biomolecules,
Год журнала:
2025,
Номер
15(6), С. 754 - 754
Опубликована: Май 23, 2025
Since
the
first
observations
of
biofilm
formation
by
microorganisms
on
various
surfaces
more
than
50
years
ago,
it
has
been
shown
that
most
“unicellular”
prefer
to
grow
in
multicellular
communities
often
adhere
surfaces.
The
microbes
these
each
other,
produce
an
extracellular
matrix
(ECM)
protects
them
from
drugs,
toxins
and
host’s
immune
system,
they
coordinate
their
development
differentiate
into
different
forms
via
signaling
molecules
nutrient
gradients.
Biofilms
are
a
serious
problem
industry,
agriculture,
marine
environment
human
animal
health.
Many
researchers
therefore
investigating
ways
disrupt
killing
or
disrupting
adhesion
surface,
quorum
sensing
ECM
production.
This
review
provides
overview
approaches
altering
through
physical,
chemical
biological
modifications
reduce/prevent
microbial
cell
maintenance.
It
also
discusses
advantages
disadvantages
approach
challenges
faced
this
field.
Язык: Английский
Aspergillus Biofilms
Springer series on biofilms,
Год журнала:
2025,
Номер
unknown, С. 299 - 319
Опубликована: Янв. 1, 2025
Nanoparticles in the battle against Candida auris biofilms: current advances and future prospects
Drug Delivery and Translational Research,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 26, 2024
Abstract
Candida
auris
has
emerged
as
a
significant
global
health
threat
due
to
its
multidrug
resistance
and
ability
form
robust
biofilms,
particularly
on
medical
devices
hospital
surfaces.
Biofilms
protect
C.
from
antifungal
treatments
the
host
immune
response,
making
infections
persistent
difficult
control.
This
review
explores
potential
of
nanoparticles
overcome
limitations
traditional
therapies
in
combating
biofilms.
Nanoparticles,
with
their
unique
physicochemical
properties,
offer
promising
strategies
penetrate
biofilm
matrices,
deliver
agents,
disrupt
structure.
Various
types
nanoparticles,
including
metallic,
polymeric,
lipid-based,
cyclodextrin-based,
demonstrate
enhanced
penetration
activity.
Their
generate
reactive
oxygen
species,
cell
adhesion,
release
antifungals
controlled
manner
makes
them
ideal
candidates
for
biofilm-targeted
therapies.
presents
current
advancements
nanoparticle-based
solutions,
emphasizing
need
further
research
into
mechanisms
action,
safety,
clinical
application.
By
addressing
challenge
biofilms
specifically,
this
provides
critical
synthesis
existing
knowledge
identifies
future
directions
developing
effective
using
nanotechnology.
Graphical
abstract
Язык: Английский