Nanoparticles in the battle against Candida auris biofilms: current advances and future prospects DOI Creative Commons
Bahgat Fayed

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Candida auris has emerged as a significant global health threat due to its multidrug resistance and ability form robust biofilms, particularly on medical devices hospital surfaces. Biofilms protect C. from antifungal treatments the host immune response, making infections persistent difficult control. This review explores potential of nanoparticles overcome limitations traditional therapies in combating biofilms. Nanoparticles, with their unique physicochemical properties, offer promising strategies penetrate biofilm matrices, deliver agents, disrupt structure. Various types nanoparticles, including metallic, polymeric, lipid-based, cyclodextrin-based, demonstrate enhanced penetration activity. Their generate reactive oxygen species, cell adhesion, release antifungals controlled manner makes them ideal candidates for biofilm-targeted therapies. presents current advancements nanoparticle-based solutions, emphasizing need further research into mechanisms action, safety, clinical application. By addressing challenge biofilms specifically, this provides critical synthesis existing knowledge identifies future directions developing effective using nanotechnology. Graphical abstract

Language: Английский

ANIDULAFUNGIN AND HUMAN MONOCYTES REDUCE Candida spp. BIOFILM WITH DIFFERENT FUNGAL BIOMASS. DOI Creative Commons
Paula Alejandra Icely, Sofia Carla Angiolini, Emilse Rodríguez

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

ABSTRACT Introduction Candida spp. bloodstream infection is a frequent form of mycosis with high mortality rates. Biofilm formation potent virulence factor for albicans and parapsilosis , that confers significant resistance to antifungal agents the innate immune response. Echinocandins such as anidulafungin are new drugs broaden available therapeutic arsenal invasive fungal treatment. Here we evaluated effect anidulafungin, human-Monocytes combined treatment on mature biofilms clinical isolates different intrinsic capacity biofilm, biofilm low (LB) biomass (HB). Methods Yeasts from blood were molecularly identified. Lipase acid aspartic protease production, adhesion capacity, ability evaluated; strains classified Weak, Moderate or Strong forming capacity. Mature LB HB incubated THP-1 cell alone exposed both, 22 h. Fungal damage induced by and/or monocytes was determined XTT[2,3-bis(2-methoxy-4-nitro-5-sulfophenyl) 2H-tetrazolium-5-carboxanilide] metabolic assay. Results Our results showed could be effective reduce most C. sensu stricto isolates, independent BF strain. Anidulafungin in combination isolates. Conclusions The effectiveness ANF seems species specific, since agent exhibits synergistic activity biofilm.

Language: Английский

Citations

0
Probiotic Potential of Yeast, Mold, and Intermediate Morphotypes of Geotrichum candidum in Modulating Gut Microbiota and Body Physiology in Mice DOI

Madeeha Gohar,

Nazma Shaheen, Sagar M. Goyal

et al.

Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0
Biofilm-Associated Candidiasis: Pathogenesis, Prevalence, Challenges and Therapeutic Options DOI Creative Commons

Valerie Amann,

Ann‐Kathrin Kissmann, Carolina Firacative

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(4), P. 460 - 460

Published: March 25, 2025

The rising prevalence of fungal infections, especially those caused by Candida species, presents a major risk to global health. With approximately 1.5 million deaths annually, the urgency for effective treatment options has never been greater. spp. are leading cause invasive significantly impacting immunocompromised patients and in healthcare settings. C. albicans, parapsilosis emerging species auris categorized as highly dangerous because their pathogenic potential increasing drug resistance. This review comparatively describes formation microbial biofilms both bacterial origin, including pathogens, thereby creating novel focus. Biofilms can further complicate treatment, these structures provide enhanced resistance antifungal therapies. Traditional agents, polyenes, azoles echinocandins, have shown effectiveness, yet development continues rise, necessitating exploration therapeutic approaches. Antimicrobial peptides (AMPs) such anti-biofilm Pom-1 Cm-p5 originally isolated from snails represent promising candidates due unique mechanisms action neglectable cytotoxicity. article discusses challenges posed characteristics important role virulence new like AMPs.

Language: Английский

Citations

0
Nanoparticles in the battle against Candida auris biofilms: current advances and future prospects DOI Creative Commons
Bahgat Fayed

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 26, 2024

Abstract Candida auris has emerged as a significant global health threat due to its multidrug resistance and ability form robust biofilms, particularly on medical devices hospital surfaces. Biofilms protect C. from antifungal treatments the host immune response, making infections persistent difficult control. This review explores potential of nanoparticles overcome limitations traditional therapies in combating biofilms. Nanoparticles, with their unique physicochemical properties, offer promising strategies penetrate biofilm matrices, deliver agents, disrupt structure. Various types nanoparticles, including metallic, polymeric, lipid-based, cyclodextrin-based, demonstrate enhanced penetration activity. Their generate reactive oxygen species, cell adhesion, release antifungals controlled manner makes them ideal candidates for biofilm-targeted therapies. presents current advancements nanoparticle-based solutions, emphasizing need further research into mechanisms action, safety, clinical application. By addressing challenge biofilms specifically, this provides critical synthesis existing knowledge identifies future directions developing effective using nanotechnology. Graphical abstract

Language: Английский

Citations

1