International Immunopharmacology, Год журнала: 2024, Номер 140, С. 112776 - 112776
Опубликована: Июль 29, 2024
Язык: Английский
Ecotoxicology and Environmental Safety, Год журнала: 2024, Номер 283, С. 116777 - 116777
Опубликована: Июль 24, 2024
Lactation women, a highly concerned demographic in society, face health risks that deserve attention. Zinc oxide nanoparticles (ZnO NPs) are widely utilized food and daily products due to their excellent physicochemical properties, leading the potential exposure of lactating women ZnO NPs. Hence, assessing associated with NP during lactation is critical. While studies have confirmed NPs can induce toxic responses multiple organs through blood circulation, effects lactational on mammary tissue remain unclear. This research investigated impairment induced by its mechanisms. Through administering injections into tail vein ICR mice, our study revealed deposit tissues, downregulating key components epithelial barrier such as ZO-1, occludin, claudin-3. In vivo, we also found simultaneously apoptosis, necroptosis, pyroptosis, called PANoptosis. Additionally, using EpH4-Ev cells simulate an vitro model, observed effectively disrupted integrity Furthermore, PANoptosis was responsible for disruption Moreover, identified ZBP1 primary mechanism inducing These discoveries designed enhance comprehension mechanisms underlying caused NPs, aim highlight hazards usage therapeutic lactation.
Язык: Английский
Процитировано
1
Viruses, Год журнала: 2024, Номер 16(8), С. 1261 - 1261
Опубликована: Авг. 6, 2024
The innate immune system serves as the first line of defense against β-coronaviruses (β-CoVs), a family viruses that includes SARS-CoV-2. Viral sensing via pattern recognition receptors triggers inflammation and cell death, which are essential components response facilitate viral clearance. However, excessive activation inflammatory death can result in uncontrolled release proinflammatory cytokines, resulting cytokine storm pathology. PANoptosis, immune, initiated by sensors driven caspases RIPKs through PANoptosome complexes, has been implicated pathology infections. Therefore, understanding molecular mechanisms regulating PANoptosis to β-CoV infection is critical for identifying new therapeutic targets mitigate disease severity. In current study, we analyzed findings from death-based CRISPR screen with archetypal mouse hepatitis virus (MHV) trigger characterize host molecules required death. As result, identified SMARCA4, chromatin regulator, putative factor MHV. Furthermore, observed gRNA-mediated deletion Smarca4 inhibited MHV-induced PANoptotic macrophages. These have potential translational clinical implications advancement treatment strategies β-CoVs other
Язык: Английский
Процитировано
1
Cellular Signalling, Год журнала: 2024, Номер 125, С. 111497 - 111497
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
1
Life Sciences, Год журнала: 2024, Номер unknown, С. 123241 - 123241
Опубликована: Ноя. 1, 2024
Язык: Английский
Процитировано
1
Expert Review of Anti-infective Therapy, Год журнала: 2024, Номер unknown, С. 1 - 14
Опубликована: Сен. 4, 2024
Lower respiratory tract infections (LRTI) remain a significant global cause of mortality and disability. Viruses constitute substantial proportion LRTI cases, with their pandemic potential posing latent threat. After the SARS-CoV-2 pandemic, resurgence other viruses, including Influenza Respiratory Syncytial Virus responsible for has been observed especially in susceptible populations.
Язык: Английский
Процитировано
0
Heliyon, Год журнала: 2024, Номер 10(18), С. e38085 - e38085
Опубликована: Сен. 1, 2024
Язык: Английский
Процитировано
0
International Immunopharmacology, Год журнала: 2024, Номер 140, С. 112776 - 112776
Опубликована: Июль 29, 2024
Язык: Английский
Процитировано
0