International Immunopharmacology, Journal Year: 2024, Volume and Issue: 140, P. 112776 - 112776
Published: July 29, 2024
Language: Английский
Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 283, P. 116777 - 116777
Published: July 24, 2024
Lactation women, a highly concerned demographic in society, face health risks that deserve attention. Zinc oxide nanoparticles (ZnO NPs) are widely utilized food and daily products due to their excellent physicochemical properties, leading the potential exposure of lactating women ZnO NPs. Hence, assessing associated with NP during lactation is critical. While studies have confirmed NPs can induce toxic responses multiple organs through blood circulation, effects lactational on mammary tissue remain unclear. This research investigated impairment induced by its mechanisms. Through administering injections into tail vein ICR mice, our study revealed deposit tissues, downregulating key components epithelial barrier such as ZO-1, occludin, claudin-3. In vivo, we also found simultaneously apoptosis, necroptosis, pyroptosis, called PANoptosis. Additionally, using EpH4-Ev cells simulate an vitro model, observed effectively disrupted integrity Furthermore, PANoptosis was responsible for disruption Moreover, identified ZBP1 primary mechanism inducing These discoveries designed enhance comprehension mechanisms underlying caused NPs, aim highlight hazards usage therapeutic lactation.
Language: Английский
Citations
1
Viruses, Journal Year: 2024, Volume and Issue: 16(8), P. 1261 - 1261
Published: Aug. 6, 2024
The innate immune system serves as the first line of defense against β-coronaviruses (β-CoVs), a family viruses that includes SARS-CoV-2. Viral sensing via pattern recognition receptors triggers inflammation and cell death, which are essential components response facilitate viral clearance. However, excessive activation inflammatory death can result in uncontrolled release proinflammatory cytokines, resulting cytokine storm pathology. PANoptosis, immune, initiated by sensors driven caspases RIPKs through PANoptosome complexes, has been implicated pathology infections. Therefore, understanding molecular mechanisms regulating PANoptosis to β-CoV infection is critical for identifying new therapeutic targets mitigate disease severity. In current study, we analyzed findings from death-based CRISPR screen with archetypal mouse hepatitis virus (MHV) trigger characterize host molecules required death. As result, identified SMARCA4, chromatin regulator, putative factor MHV. Furthermore, observed gRNA-mediated deletion Smarca4 inhibited MHV-induced PANoptotic macrophages. These have potential translational clinical implications advancement treatment strategies β-CoVs other
Language: Английский
Citations
1
Cellular Signalling, Journal Year: 2024, Volume and Issue: 125, P. 111497 - 111497
Published: Nov. 1, 2024
Language: Английский
Citations
1
Life Sciences, Journal Year: 2024, Volume and Issue: unknown, P. 123241 - 123241
Published: Nov. 1, 2024
Language: Английский
Citations
1
Expert Review of Anti-infective Therapy, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 14
Published: Sept. 4, 2024
Lower respiratory tract infections (LRTI) remain a significant global cause of mortality and disability. Viruses constitute substantial proportion LRTI cases, with their pandemic potential posing latent threat. After the SARS-CoV-2 pandemic, resurgence other viruses, including Influenza Respiratory Syncytial Virus responsible for has been observed especially in susceptible populations.
Language: Английский
Citations
0
Heliyon, Journal Year: 2024, Volume and Issue: 10(18), P. e38085 - e38085
Published: Sept. 1, 2024
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 140, P. 112776 - 112776
Published: July 29, 2024
Language: Английский
Citations
0