Heliyon, Год журнала: 2023, Номер 9(7), С. e17703 - e17703
Опубликована: Июнь 30, 2023
Essential oils are thought as potential therapies in managing coronavirus disease 2019 (COVID-19). Many researchers have put their efforts to tackle the pandemic by exploring antiviral candidates which consequently changes research landscape. Herein, we aimed assess effect of COVID-19 toward landscape essential oil research.
Язык: Английский
Scientia Pharmaceutica, Год журнала: 2023, Номер 91(1), С. 15 - 15
Опубликована: Март 6, 2023
Essential oils are potential therapeutics for coronavirus disease 2019 (COVID-19), in which some of the volatile compounds essential have been well known their broad antiviral activities. These therapeutic candidates shown to regulate excessive secretion pro-inflammatory cytokines, underlies pathogenesis severe COVID-19. We aimed identify molecular targets disrupting cell entry and replication SARS-CoV-2, hence being active as antivirals. Literature searches were performed on PubMed, Scopus, Scillit, CaPlus/SciFinder (7 December 2022) with a truncated title implying anti-SARS-CoV-2 activity oil. Data collected from eligible studies described narratively. Quality appraisal was included studies. A total eight this review; four used enzyme inhibition assay, one—pseudo-SARS-CoV-2 culture; two—whole SARS-CoV-2 one—ACE2-expressing cancer cells. may prevent infection by targeting its receptors cells (ACE2 TMPRSS2). Menthol, 1,8-cineole, camphor among serve ACE2 blockers. β-caryophyllene selectively target spike protein inhibit viral entry. Other interactions proteases RdRp observed based docking. In conclusion, could proteins related replication. Further improved uniform study designs should be carried out optimize COVID-19 therapies.
Язык: Английский
Процитировано
25
Cells, Год журнала: 2021, Номер 10(12), С. 3291 - 3291
Опубликована: Ноя. 24, 2021
Hyperactivation of immune responses resulting in excessive release pro-inflammatory mediators alveoli/lung structures is the principal pathological feature coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2). The cytokine hyperactivation COVID-19 appears to be similar those seen rheumatoid arthritis (RA), an autoimmune disease. Emerging evidence conferred severity and risk RA patients. Amid musculoskeletal manifestations involving immune-inflammation-dependent mechanisms cases arthralgia and/or myalgia COVID-19, crosstalk between often debated. present article sheds light on RA, patients acquiring SARS-CoV-2 infection, aspects infection development. We also whether can exacerbate outcomes based available clinical readouts. mechanistic overlapping immune-inflammatory features both was discussed. showed emerging links angiotensin-converting enzyme (ACE)-dependent macrophage-mediated pathways diseases. Moreover, a detailed review immediate challenges key recommendations for anti-rheumatic drugs setting presented better monitoring management Taken together, summarizes knowledge their overlaps, challenges, therapeutic options.
Язык: Английский
Процитировано
55
Acta Haematologica, Год журнала: 2022, Номер 145(3), С. 282 - 296
Опубликована: Янв. 1, 2022
Coronavirus disease 2019 (COVID-19) has emerged as a pandemic at the end of and continues to exert an unfavorable worldwide health impact on large proportion population. A remarkable feature COVID-19 is precipitation hypercoagulable state, mainly in severe cases, leading micro- macrothrombosis, respiratory failure, death. Despite implementation various therapeutic regimes, including anticoagulants, number patients suffer from such serious complications. This review aims describe current knowledge pathophysiology coagulation mechanism COVID-19. We interplay between three important mediators how this may lead hyperinflammatory prothrombotic state that affects outcome, namely, endothelium, immune system, system. In line with hypercoagulability during COVID-19, we further rare but vaccine-induced thrombotic thrombocytopenia. also summarize comment available anticoagulant treatment options include suggestions for some future considerations anticoagulation therapy.
Язык: Английский
Процитировано
31
Frontiers in Endocrinology, Год журнала: 2022, Номер 13
Опубликована: Июнь 17, 2022
Muscle and adipose tissue produce irisin during exercise. Irisin is thermogenic adipomyokine, improves glucose lipid metabolism, ameliorates the effects of obesity-driven inflammation, metabolic syndrome, diabetes. In addition, exercise-induced activates anti-inflammatory pathways may play an essential role in improving outcomes inflammatory conditions, such as coronavirus disease (COVID-19). COVID-19 infection can activate different intracellular receptors modulate various course disease. The cytokine release storm (CRS) produced significant because it promotes context for systemic which increases risk mortality patients with severe acute respiratory syndrome 2 (SARS-CoV2). viral resulting organ damage stimulate mitogen-activated protein kinase(MAPK) toll-like receptor 4 (TLR4)/toll interleukin (TIR)-domain-containing adaptor (MyD88) while negatively modulating AMP-activated kinase (AMPK) pathway, leading to increased production. Exercise-induced counteract this modulation by decreasing Consequently, levels, found healthy patients, favor a better prognosis SARS-CoV2. This review aims explore molecular mechanisms underlying properties mitigating CRS preventing due
Язык: Английский
Процитировано
31
Expert Review of Clinical Immunology, Год журнала: 2022, Номер 18(11), С. 1187 - 1202
Опубликована: Сен. 1, 2022
Background and aims Severe manifestations of coronavirus disease 2019 (COVID-19) are associated with alterations in blood cells that regulate immunity, inflammation, hemostasis. We conducted an updated systematic review meta-analysis the association between neutrophil, lymphocyte, platelet count, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), COVID-19 progression mortality.Methods A literature search was PubMed, Web Science, Scopus for studies published January 2020 June 2022.Results In 71 reporting investigated parameters within 48 hours admission, higher NLR (HR 1.21, 95% CI 1.16 to 1.27, p < 0.0001), relative neutrophilia 1.62, 1.46 1.80, lymphopenia 1.27 2.08, 0.001), thrombocytopenia 1.74, 1.36 2.22, but not PLR (p = 0.11), were significantly mortality. Between-study heterogeneity large-to-extreme. The magnitude direction effect size modified sensitivity analysis.Conclusions count discriminate patients different survival outcomes. (PROSPERO registration number: CRD42021267875).
Язык: Английский
Процитировано
30
Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)
Опубликована: Март 22, 2023
Abstract Background COVID-19, the current global pandemic caused by SARS-CoV-2 infection, can damage heart and lead to failure (HF) even cardiac death. The 2',5'-oligoadenylate synthetase (OAS) gene family encode interferon (IFN)-induced antiviral proteins which is associated with immune responses of COVID-19. While potential association OAS injury in COVID-19 has not been determined. Methods expression levels biological functions infected cardiomyocytes dataset (GSE150392) HF (GSE120852) were determined comprehensive bioinformatic analysis experimental validation. microRNAs (miRNAs) explored from Targetscan GSE104150. family-regulatory chemicals or ingredients predicted using Comparative Toxicogenomics Database (CTD) SymMap database. Results genes highly expressed both failing hearts. differentially (DEGs) two datasets enriched cardiovascular disease related pathways. miRNAs-target indicated that 10 miRNAs could increase genes. A variety regulating especially estradiol. Conclusion an important mediator may serve as a therapeutic target for
Язык: Английский
Процитировано
18
Vaccines, Год журнала: 2024, Номер 12(6), С. 566 - 566
Опубликована: Май 22, 2024
The share of the elderly population is growing worldwide as life expectancy increases. Immunosenescence and comorbidities increase infectious diseases’ morbidity mortality in older adults. Here, we aimed to summarize latest findings on vaccines for against herpes zoster, influenza, respiratory syncytial virus (RSV), COVID-19, pneumococcal disease examine vaccine recommendation differences this age group Europe United States. PubMed was searched using keywords “elders” “vaccine” alongside disease/pathogen question paraphrased or synonymous terms. Vaccine recommendations were also sought European US Centers Disease Control Prevention databases. Improved vaccines, tailored elderly, mainly by novel adjuvants increasing antigen concentration, are now available. Significant exist between immunization policies, especially countries, terms recipient’s age, number doses, vaccination schedule, implementation (mandatory recommended). Understanding factors that influence immune response may help design offer long-term protection vulnerable group. A consensus-based strategy could fill gaps policy particularly regarding RSV pneumococcus.
Язык: Английский
Процитировано
8
Journal of Medical Virology, Год журнала: 2021, Номер 94(4), С. 1523 - 1534
Опубликована: Ноя. 30, 2021
Abstract The benefits of baricitinib in coronavirus disease‐2019 are inadequately defined. We performed a systematic review and meta‐analysis studies to determine its clinical efficacy adverse events patients with COVID‐19. Databases were searched from their inception September 5, 2021. primary outcome was the coefficient mortality. also compared secondary indicators between treatment placebo or other treatments. Twelve 3564 included assessed qualitatively (modified Jadad Newcastle–Ottawa Scale scores). Baricitinib effectively improved mortality rate (relative risk = 0.56; 95% confidence interval: 0.46–0.69; p < 0.001; I 2 2%), this result unchanged by subgroup analysis. intensive care unit admission, requirement for invasive mechanical ventilation, oxygenation index. Data these showed that slightly reduced events. Regarding choice drug dosage baricitinib, high‐dose group appeared have additional efficacy. Our study shows may be promising, safe, effective anti‐severe acute respiratory syndrome‐coronavirus‐2 candidate, advantages low cost, easy production, convenient storage.
Язык: Английский
Процитировано
41
Frontiers in Immunology, Год журнала: 2022, Номер 13
Опубликована: Март 22, 2022
The coronavirus disease 2019 (COVID-19) pandemic has had an enormous impact on the world, affecting people's lifestyle, economy, and livelihood. Recently, with development of vaccines, number infected cases decreased. Many case reports have revealed that COVID-19 may induce other serious comorbidities such as anti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis. Anti-NMDA encephalitis is acute autoimmune occurs more commonly in women than men. To explore association between anti-NMDA encephalitis, microRNA (miRNA) biomarkers COVID-19, related diseases from literature are reviewed; then basis these miRNA biomarkers, relationship discussed. miRNAs small non-coding RNAs play important roles cell differentiation, development, cell-cycle regulation, apoptosis. been used biological for many diseases. results this study reveal infection or vaccination cannot be excluded; however, risk triggers not high.
Язык: Английский
Процитировано
27
Frontiers in Neuroscience, Год журнала: 2022, Номер 16
Опубликована: Окт. 20, 2022
Background Growing evidence suggests that the central nervous system is affected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), since infected patients suffer from and long-term neurological sequelae. Nevertheless, it currently unknown whether virus affects brain cortex. The purpose of this study was to assess cortical gray matter volume, thickness, surface area in a group SARS-CoV-2 with symptoms compared healthy control subjects. Additionally, we analyzed features association inflammatory biomarkers cerebrospinal fluid (CSF) plasma. Materials methods Thirty-three were selected prospective cross-sectional cohort during ongoing pandemic (August 2020–April 2021) at university hospitals Basel Zurich (Switzerland). included different symptom severity (Class I: nearly asymptomatic/mild symptoms, II: moderate III: symptoms). age sex-matched subjects underwent same MRI protocol served as controls. For each anatomical T1w MPRAGE image, regional computed FreeSurfer. Using linear regression model, measures between groups (patients vs. controls; Class I II–III), age, sex, magnetic field strength, total intracranial volume/mean thickness/total covariates. In subgroup patients, clinical parameters assessed using partial correlation adjusting for P -values corrected false discovery rate (FDR). Results Our findings revealed lower volume COVID-19 patients’ orbitofrontal, frontal, cingulate regions than controls ( p < 0.05). Regional thickness decreases negatively associated CSF protein levels, CSF/blood-albumin ratio, EN-RAGE levels. Conclusion data suggest viral-triggered inflammation leads neurotoxic damage some areas phase infection symptoms.
Язык: Английский
Процитировано
27