A Comprehensive Analysis of Structural and Functional Changes Induced by SARS-CoV-2 Spike Protein Mutations DOI Creative Commons
Aganze Gloire-Aimé Mushebenge, Samuel Chima Ugbaja, Nonkululeko Avril Mbatha

и другие.

COVID, Год журнала: 2023, Номер 3(9), С. 1454 - 1472

Опубликована: Сен. 16, 2023

The emergence of SARS-CoV-2, the virus responsible for COVID-19 pandemic, has sparked intense research on its spike protein, which is essential viral entrance into host cells. Viral reproduction and transmission, immune response regulation, receptor recognition cell mechanisms, as well structural functional effects have all been linked to mutations in protein. Spike protein can also result evasion mechanisms that impair vaccine effectiveness escape, they are illness severity clinical consequences. Numerous studies conducted determine these structure how it interacts with factors. These results important implications design development medicines vaccines based proteins assessment those products’ efficiency against newly discovered mutations. This paper gives a general overview categorized named. It further looks at links between outcomes, severity, unanswered problems, future prospects. Additionally, explored possible therapeutic targeting

Язык: Английский

Spatiotemporal genome diversity of SARS-CoV-2 in wastewater: a two-year global epidemiological study DOI
Manisha Mandal, Shyamapada Mandal

Environmental Monitoring and Assessment, Год журнала: 2023, Номер 196(1)

Опубликована: Дек. 16, 2023

Язык: Английский

Процитировано

8
Coronavirus envelope protein activates TMED10-mediated unconventional secretion of inflammatory factors DOI Creative Commons
Lei Liu,

Lijingyao Zhang,

Xinyan Hao

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Окт. 8, 2024

The precise cellular mechanisms underlying heightened proinflammatory cytokine production during coronavirus infection remain incompletely understood. Here we identify the envelope (E) protein in severe coronaviruses (SARS-CoV-2, SARS, or MERS) as a potent inducer of interleukin-1 release, intensifying lung inflammation through activation TMED10-mediated unconventional secretion (UcPS). In contrast, E mild (229E, HKU1, OC43) demonstrates less pronounced effect. contains an SS/DS motif, which is not present milder strains and facilitates interaction with TMED10. This enhances TMED10-oligomerization, facilitating UcPS cargo translocation into ER-Golgi intermediate compartment (ERGIC)-a pivotal step UcPS. Progesterone analogues were identified compounds inhibiting E-enhanced release factors Mouse Hepatitis Virus (MHV) model. These findings elucidate molecular mechanism driving coronavirus-induced hyperinflammation, proposing E-TMED10 potential therapeutic target to counteract adverse effects inflammation.

Язык: Английский

Процитировано

2
Performance Analysis of Self-Collected Nasal and Oral Swabs for Detection of SARS-CoV-2 DOI Creative Commons
Ho Jae Lim, Young-Hyun Baek, Min‐Young Park

и другие.

Diagnostics, Год журнала: 2022, Номер 12(10), С. 2279 - 2279

Опубликована: Сен. 21, 2022

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third highly pathogenic human and rapidly transmitted by infected individuals regardless of their symptoms. During COVID-19 pandemic, owing to dearth skilled healthcare workers (HCWs) collect samples for early diagnosis, self-collection emerged as a viable alternative. To evaluate reliability self-collection, we compared virus detection rate using 3990 self-collected swabs HCW-collected swabs, procured from same collected immediately after self-collection. The results multiplex reverse-transcription quantitative polymerase chain reaction revealed that viral load in was marginally (18.4-28.8 times) higher than swabs. Self-collection showed no significant difference sensitivity specificity HCW-collection (κ = 0.87, McNemar's test; p 0.19), indicating comparable performance. These findings suggest are acceptable substitutes use improved specimen screening efficiency reduced risk SARS-CoV-2 infection among HCWs during pandemic.

Язык: Английский

Процитировано

9
Divergent mutations of Delta and Omicron variants: key players behind differential viral attributes across the COVID-19 waves DOI Open Access
Amrita Panja, Jayita Roy,

Anup Mazumder

и другие.

VirusDisease, Год журнала: 2023, Номер 34(2), С. 307 - 320

Опубликована: Май 10, 2023

Язык: Английский

Процитировано

5
A Comprehensive Analysis of Structural and Functional Changes Induced by SARS-CoV-2 Spike Protein Mutations DOI Creative Commons
Aganze Gloire-Aimé Mushebenge, Samuel Chima Ugbaja, Nonkululeko Avril Mbatha

и другие.

COVID, Год журнала: 2023, Номер 3(9), С. 1454 - 1472

Опубликована: Сен. 16, 2023

The emergence of SARS-CoV-2, the virus responsible for COVID-19 pandemic, has sparked intense research on its spike protein, which is essential viral entrance into host cells. Viral reproduction and transmission, immune response regulation, receptor recognition cell mechanisms, as well structural functional effects have all been linked to mutations in protein. Spike protein can also result evasion mechanisms that impair vaccine effectiveness escape, they are illness severity clinical consequences. Numerous studies conducted determine these structure how it interacts with factors. These results important implications design development medicines vaccines based proteins assessment those products’ efficiency against newly discovered mutations. This paper gives a general overview categorized named. It further looks at links between outcomes, severity, unanswered problems, future prospects. Additionally, explored possible therapeutic targeting

Язык: Английский

Процитировано

5