Molecules,
Год журнала:
2024,
Номер
29(17), С. 4234 - 4234
Опубликована: Сен. 6, 2024
Plants
are
a
rich
source
of
secondary
metabolites,
among
which
phenolics
the
most
abundant.
To
date,
over
8000
various
polyphenolic
compounds
have
been
identified
in
plant
species,
phenolic
acids,
flavonoids,
coumarins,
stilbenes
and
lignans
important
ones.
Acne
is
one
commonly
treated
dermatological
diseases,
acne
vulgaris
rosacea
frequently
diagnosed.
In
scientific
literature,
there
lack
detailed
presentation
discussion
on
importance
treatment
common
specific
skin
e.g.,
acne.
Therefore,
aim
this
review
to
gather,
present
discuss
current
state
knowledge
activity
towards
prevention
acne,
including
vitro,
vivo
human
studies.
It
was
revealed
that
because
their
significant
antibacterial,
anti-inflammatory
antioxidant
activities,
may
be
used
types
individually
as
well
combination
with
drugs
like
clindamycin
benzoyl
peroxide.
Among
tested,
EGCG,
quercetin
nobiletin
seem
promising
ones;
however,
more
studies,
especially
clinical
trials,
needed
fully
evaluate
efficacy
treating
The Cell Surface,
Год журнала:
2023,
Номер
10, С. 100112 - 100112
Опубликована: Окт. 20, 2023
One
of
the
biggest
issues
for
medical
professionals
and
a
serious
global
concern
is
emergence
multi-drug-resistant
bacteria,
which
result
overuse
or
misuse
antimicrobial
agents.
To
combat
this
urgent
problem,
new
drugs
with
alternative
mechanisms
action
are
continuously
replacing
conventional
antimicrobials.
Nanotechnology-fueled
innovations
provide
patients
hope
overcoming
drug
resistance.
The
aim
present
work
was
to
document
potential
metallic
nanoparticles
against
bacterial
pathogens.
Cell
wall
interaction
membrane
penetration,
reactive
oxygen
species
(ROS)
production,
DNA
damage,
protein
synthesis
inhibition
were
some
generalised
recognised
in
current
study.
In
vitro
vivo
studies
demonstrated
that
toxicity
concerns
development
resistance
(NPs)
harden
use
NP
products
treatment
drug-resistant
Therefore,
researchers
across
globe
should
actively
engage
solving
above-mentioned
issues.
Antibiotics,
Год журнала:
2025,
Номер
14(1), С. 63 - 63
Опубликована: Янв. 9, 2025
Multidrug
antimicrobial
resistance
(AMR)
represents
a
formidable
challenge
in
the
therapy
of
infectious
diseases,
triggered
by
particularly
concerning
gram-negative
Enterococcus
faecium,
Staphylococcus
aureus,
Klebsiella
pneumoniae,
Acinetobacter
baumannii,
Pseudomonas
aeruginosa,
and
Enterobacter
spp.
(ESKAPE)
pathogens.
Designated
as
"priority"
2017,
these
bacteria
continue
to
pose
significant
threat
2024,
during
worldwide
SARS-CoV-2
pandemic,
where
coinfections
with
ESKAPE
members
contributed
worsened
patient
outcomes.
The
declining
effectiveness
current
treatments
against
pathogens
has
led
an
increased
disease
burden
increase
mortality
rates
globally.
This
review
explores
sophisticated
mechanisms
driving
AMR
bacteria,
focusing
on
Key
bacterial
contributing
include
limitations
drug
uptake,
production
antibiotic-degrading
enzymes,
alterations
target
sites,
enhanced
efflux
systems.
Comprehending
pathways
is
vital
for
formulating
innovative
therapeutic
strategies
tackling
ongoing
posed
resistant
Toxics,
Год журнала:
2024,
Номер
12(3), С. 174 - 174
Опубликована: Фев. 24, 2024
While
the
use
of
antibiotics
has
been
reported
as
extensive
in
rearing
agricultural
animals,
insufficient
information
is
available
on
antibiotic
residues
animal
products
and
adverse
impact
that
consistent
low-level
exposure
to
might
have
human
body
its
microbiome.
The
aim
this
study
was
estimate
concentrations
humans
are
exposed
via
their
diet
using
concentration
food
water
an
online
survey
dietary
intake.
A
total
131
participants
completed
intake
survey,
with
majority
belonging
omnivorous
group
(76.3%).
Distinct
trends
were
observed
unknown
groups
eating
products,
specific
types
dominating
each
meal:
pork
(e.g.,
ham)
dairy
milk,
yoghurt)
during
breakfast,
beef
burgers)
chicken
breast)
lunch,
fish
salmon
fillet)
dinner.
In
total,
34
different
animal-based
drink
tested
for
presence
ten
antibiotics.
Of
all
tested,
over
35%
exceeded
acceptable
daily
amoxicillin,
ampicillin,
enrofloxacin.
Scientific Reports,
Год журнала:
2024,
Номер
14(1)
Опубликована: Фев. 6, 2024
Abstract
The
numbers
of
infections
caused
by
Gram-negative
bacteria
(GNB)
that
produce
extended-spectrum
beta-lactamases
(ESBLs)
and
those
are
carbapenem
resistant,
especially
Escherichia
coli
(
E.
)
Klebsiella
pneumoniae
(K.
),
increasing,
these
becoming
a
global
public
health
problem.
aim
this
study
was
to
assess
the
prevalence
ESBL-producing
carbapenem-resistant
bacilli
in
patients
hospitalized
at
An-Najah
National
University
Hospital
Nablus,
Palestine,
provide
healthcare
workers
with
valuable
information
on
treatment
infections.
A
retrospective
cross-sectional
investigation
conducted
large
tertiary
care
teaching
hospital.
included
admitted
hospital
between
January
December
2021,
from
whom
were
isolated.
patients'
clinical
demographic
obtained
system.
In
addition,
regarding
bacterial
isolates
antibiotic
resistance
hospital's
microbiology
laboratory.
This
total
188
patients—91
males
(48.4%)
97
females
(51.6%).
general
surgical
ward
accounted
for
highest
proportion
(30.9%),
followed
ICU
(12.2%).
most
common
coli,
which
62.8%
cases.
Among
them,
urinary
tract
microorganism
prevalent
(44.7%
patients).
Over
50%
(54.2%)
had
history
use,
77.8%
been
within
past
three
months.
significantly
isolated
blood
cultures
p
-value
=
0.000),
CR-
K.
endotracheal
0.001).
emphasizes
concerning
frequency
healthcare-acquired
GNB
substantial
presents
considerable
obstacles
successful
administration
routinely
employed
antibiotics.
results
highlight
immediate
need
improved
antimicrobial
stewardship
implementation
infection
control
strategies
reduce
effects
multidrug-resistant
patient
well-being
health.
