Introduction
Recent
studies
have
explored
alternative
methods
to
enhance
caries
prevention
and
treatment.
Luteolin
compound
has
been
noted
for
its
antimicrobial
properties,
while
zinc
nanoparticles
(Zn
NPs)
are
recognized
their
potent
antibacterial
effects.
This
study
investigates
the
synthesis,
characterization,
efficacy
of
luteolin-loaded
Zn
oxide
NPs
(Luteo-ZnONPs)
against
cariogenic
bacteria.
By
combining
biofilm-targeting
capabilities
luteolin
with
properties
NPs,
we
aim
explore
a
novel
approach
dental
management.
Methods
Luteo-ZnONPs
were
synthesized
characterized
using
ultraviolet-visible
(UV-vis)
Fourier
transform
infrared
(FTIR)
spectroscopy,
confirming
successful
formation
stability.
Antimicrobial
was
assessed
through
minimum
inhibitory
concentration
(MIC),
demonstrating
effectiveness
bacteria
such
as
Oral
squamous
cell
carcinoma
(OSCC)
is
a
prevalent
oral
malignancy,
which
poses
significant
health
risks
with
high
mortality
rate.
Regulatory
T
cells
(Tregs),
characterized
by
their
immunosuppressive
capabilities,
are
intricately
linked
to
OSCC
progression
and
patient
outcomes.
The
metabolic
reprogramming
of
Tregs
within
the
tumor
microenvironment
(TME)
underpins
function,
key
pathways
such
as
tryptophan-kynurenine-aryl
hydrocarbon
receptor,
PI3K-Akt-mTOR
nucleotide
metabolism
significantly
contributing
suppressive
activities.
Targeting
these
offers
novel
therapeutic
approach
reduce
Treg-mediated
immunosuppression
enhance
anti-tumor
responses.
This
review
explores
dependencies
that
sustain
Treg
function
in
OSCC,
highlighting
adaptations
glycolysis,
fatty
acid
oxidation,
amino
signaling
pathway
enable
thrive
challenging
conditions
TME.
Additionally,
discusses
influence
microbiome
on
evaluates
potential
strategies
targeting
pathways.
Despite
promising
interventions,
challenges
selectivity,
toxicity,
heterogeneity,
resistance
mechanisms
remain.
concludes
perspectives
personalized
medicine
integrative
approaches,
emphasizing
need
for
continued
research
translate
findings
into
effective
clinical
applications
treatment.
Cell Proliferation,
Год журнала:
2024,
Номер
57(9)
Опубликована: Май 29, 2024
Biofilm
formation
constitutes
the
primary
cause
of
various
chronic
infections,
such
as
wound
gastrointestinal
inflammation
and
dental
caries.
While
preliminary
achievement
biofilm
inhibition
is
possible,
challenge
lies
in
difficulty
eliminating
bactericidal
effects
current
drugs
that
lead
to
microbiota
imbalance.
This
study,
utilizing
vitro
vivo
models
caries,
aims
efficiently
inhibit
without
inducing
effects,
even
against
pathogenic
bacteria.
The
tetrahedral
framework
nucleic
acid
(tFNA)
was
employed
a
delivery
vector
for
small-molecule
inhibitor
(smI)
specifically
targeting
activity
glucosyltransferases
C
(GtfC).
It
observed
tFNA
loaded
smI
small-groove
binding
manner,
transferring
it
into
Streptococcus
mutans,
thereby
inhibiting
GtfC
extracellular
polymeric
substances
compromising
bacterial
survival.
Furthermore,
smI-loaded
demonstrated
reduction
severity
caries
adversely
affecting
oral
microbial
diversity
exhibited
desirable
topical
systemic
biosafety.
study
emphasizes
concept
'ecological
prevention
biofilm',
which
anticipated
advance
optimization
strategies
clinical
application
DNA
nanocarrier-based
drug
formulations.
Langmuir,
Год журнала:
2024,
Номер
40(22), С. 11806 - 11816
Опубликована: Май 21, 2024
Antibacterial
peptides
(ABPs)
have
been
recognized
as
promising
alternatives
to
conventional
antibiotics
due
their
broad
antibacterial
spectrum,
high
activity,
and
low
possibility
of
inducing
bacterial
resistance.
However,
antibiofilm
mechanisms
not
yet
reached
a
consensus.
In
this
study,
we
investigated
the
activity
short
helical
peptide
G3
against
Abstract
Introduction
Nanotechnology
offers
new
approaches
and
endless
opportunities
for
remineralizing
tooth
decay
without
being
toxic
or
causing
allergies.
This
study
aimed
to
determine
the
effect
of
nanosilver
fluoride
(NSF)
on
remineralization
potential
enamel
caries-like
lesions
compared
5%
sodium
varnish
in
permanent
teeth.
Methods
Fifteen
teeth
(molars
premolars)
were
gathered,
cleaned,
polished
using
a
scaler.
After
sectioning
mesiodistally
removing
roots,
thirty
specimens
subjected
demineralized
solution
induce
early
then
assigned
randomly
into
two
equal
groups.
The
test
materials
applied,
all
pH
cycling
model
30
days.
DIAGNOdent
surface
roughness
investigated,
an
evaluation
Ca
P
weight%
Ca/P
ratio
calculation
was
done
SEM-EDX
analyze
at
end
study.
data
analyzed
independent
t-test.
Results
mean
values
measurements
NSF
NaF
baseline
after
demineralization
not
significantly
different
(
p
>
0.05).
treatment,
showed
higher
measurement
(11.8
±
5.80)
than
(4.7
1.6).
group
(1.64
0.39)
much
NSF’s
(1.07
0.21).
Specimens
treated
with
had
statistically
significant
smoother
surfaces
<
0.001).
(2.9
0.35)
(2.2
0.11).
difference
=
0.012).
Conclusion
reveals
that
nano
silver
is
more
effective
treatment
enhancing
teeth’s
clinical
characteristics,
particularly
terms
mineral
content
roughness,
suggesting
it
could
be
improved
strategy
prevent
dental
caries
maintain
integrity.
Introduction
Recent
studies
have
explored
alternative
methods
to
enhance
caries
prevention
and
treatment.
Luteolin
compound
has
been
noted
for
its
antimicrobial
properties,
while
zinc
nanoparticles
(Zn
NPs)
are
recognized
their
potent
antibacterial
effects.
This
study
investigates
the
synthesis,
characterization,
efficacy
of
luteolin-loaded
Zn
oxide
NPs
(Luteo-ZnONPs)
against
cariogenic
bacteria.
By
combining
biofilm-targeting
capabilities
luteolin
with
properties
NPs,
we
aim
explore
a
novel
approach
dental
management.
Methods
Luteo-ZnONPs
were
synthesized
characterized
using
ultraviolet-visible
(UV-vis)
Fourier
transform
infrared
(FTIR)
spectroscopy,
confirming
successful
formation
stability.
Antimicrobial
was
assessed
through
minimum
inhibitory
concentration
(MIC),
demonstrating
effectiveness
bacteria
such
as
