Effects of AI-2 quorum sensing related luxS gene on Streptococcus suis formatting monosaccharide metabolism-dependent biofilm DOI
Shuji Gao, Shuo Yuan,

Yingying Quan

и другие.

Archives of Microbiology, Год журнала: 2024, Номер 206(10)

Опубликована: Сен. 19, 2024

Язык: Английский

Targeting AI-2 quorum sensing: harnessing natural products against Streptococcus suis biofilm infection DOI Creative Commons
Shuji Gao, Shuo Yuan,

Yingying Quan

и другие.

Veterinary Research, Год журнала: 2025, Номер 56(1)

Опубликована: Фев. 4, 2025

Abstract The biofilm acts as a protective layer for Streptococcus suis ( S. ), contributing to the development of drug resistance and chronic infections. Autoinducer 2 (AI-2) quorum sensing represents primary regulatory pathway governing formation in . Consequently, targeting AI-2 inhibit promising strategy preventing managing infections caused by This study established small natural product library integrating commercial molecules with Chinese herbal medicine molecules. two products, salvianolic acid A (SAA) rhapontin (RH), which target via sensing, were identified. SAA RH synthesis through noncompetitive competitive binding S-ribosylhomocysteinase (LuxS). By inhibiting these compounds modulate expression adhesion genes extracellular polysaccharides (EPS), reducing ability ultimately formation. Using LC‒MS/MS, we further analysed impact on metabolic activity , revealing potential medicinal value compounds. Finally, efficacy against infection was validated Galleria mellonella larvae, confirming their significant anti-infection effects.

Язык: Английский

Процитировано

1
Fe (II)/Fe (III) regulated adaptive biofilm responses and microbial metabolic mechanisms for enhanced cycloalkane biodegradation DOI
Zhirong Sun, Zhuowei Cheng, Jiade Wang

и другие.

Chemical Engineering Journal, Год журнала: 2024, Номер 500, С. 157388 - 157388

Опубликована: Ноя. 1, 2024

Язык: Английский

Процитировано

4
Effects of Environment Regulating T4SS on Virulence and Adaptability of Streptococcus suis DOI
Yamin Shen, Yue Li,

Yingying Quan

и другие.

Environmental Research, Год журнала: 2025, Номер 268, С. 120751 - 120751

Опубликована: Янв. 6, 2025

Язык: Английский

Процитировано

0
Cross-Talk Between Signal Transduction Systems and Metabolic Networks in Bacterial Antibiotics Resistance and Tolerance DOI
Shuji Gao, Baobao Liu, Shuo Yuan

и другие.

International Journal of Antimicrobial Agents, Год журнала: 2025, Номер unknown, С. 107479 - 107479

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Streptococcus suis regulates central carbon fluxes in response to environment to balance drug resistance and virulence DOI
Shuo Yuan, Baobao Liu,

Yingying Quan

и другие.

Microbiological Research, Год журнала: 2025, Номер unknown, С. 128157 - 128157

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Uncovering the toxic effects and adaptive mechanisms of aminated polystyrene nanoplastics on microbes in sludge anaerobic digestion system: Insight from extracellular to intracellular DOI
Weixin Zhao, Hao Ma,

Zhelu Gao

и другие.

Journal of Hazardous Materials, Год журнала: 2024, Номер 480, С. 136163 - 136163

Опубликована: Окт. 13, 2024

Язык: Английский

Процитировано

3
Effects of AI-2 quorum sensing related luxS gene on Streptococcus suis formatting monosaccharide metabolism-dependent biofilm DOI
Shuji Gao, Shuo Yuan,

Yingying Quan

и другие.

Archives of Microbiology, Год журнала: 2024, Номер 206(10)

Опубликована: Сен. 19, 2024

Язык: Английский

Процитировано

2