Effects of AI-2 quorum sensing related luxS gene on Streptococcus suis formatting monosaccharide metabolism-dependent biofilm DOI
Shuji Gao, Shuo Yuan,

Yingying Quan

et al.

Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(10)

Published: Sept. 19, 2024

Language: Английский

Targeting AI-2 quorum sensing: harnessing natural products against Streptococcus suis biofilm infection DOI Creative Commons
Shuji Gao, Shuo Yuan,

Yingying Quan

et al.

Veterinary Research, Journal Year: 2025, Volume and Issue: 56(1)

Published: Feb. 4, 2025

Abstract The biofilm acts as a protective layer for Streptococcus suis ( S. ), contributing to the development of drug resistance and chronic infections. Autoinducer 2 (AI-2) quorum sensing represents primary regulatory pathway governing formation in . Consequently, targeting AI-2 inhibit promising strategy preventing managing infections caused by This study established small natural product library integrating commercial molecules with Chinese herbal medicine molecules. two products, salvianolic acid A (SAA) rhapontin (RH), which target via sensing, were identified. SAA RH synthesis through noncompetitive competitive binding S-ribosylhomocysteinase (LuxS). By inhibiting these compounds modulate expression adhesion genes extracellular polysaccharides (EPS), reducing ability ultimately formation. Using LC‒MS/MS, we further analysed impact on metabolic activity , revealing potential medicinal value compounds. Finally, efficacy against infection was validated Galleria mellonella larvae, confirming their significant anti-infection effects.

Language: Английский

Citations

1
Fe (II)/Fe (III) regulated adaptive biofilm responses and microbial metabolic mechanisms for enhanced cycloalkane biodegradation DOI
Zhirong Sun, Zhuowei Cheng, Jiade Wang

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 500, P. 157388 - 157388

Published: Nov. 1, 2024

Language: Английский

Citations

4
Effects of Environment Regulating T4SS on Virulence and Adaptability of Streptococcus suis DOI
Yamin Shen, Yue Li,

Yingying Quan

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: 268, P. 120751 - 120751

Published: Jan. 6, 2025

Language: Английский

Citations

0
Cross-Talk Between Signal Transduction Systems and Metabolic Networks in Bacterial Antibiotics Resistance and Tolerance DOI
Shuji Gao, Baobao Liu, Shuo Yuan

et al.

International Journal of Antimicrobial Agents, Journal Year: 2025, Volume and Issue: unknown, P. 107479 - 107479

Published: Feb. 1, 2025

Language: Английский

Citations

0
Streptococcus suis regulates central carbon fluxes in response to environment to balance drug resistance and virulence DOI
Shuo Yuan, Baobao Liu,

Yingying Quan

et al.

Microbiological Research, Journal Year: 2025, Volume and Issue: unknown, P. 128157 - 128157

Published: March 1, 2025

Language: Английский

Citations

0
Uncovering the toxic effects and adaptive mechanisms of aminated polystyrene nanoplastics on microbes in sludge anaerobic digestion system: Insight from extracellular to intracellular DOI
Weixin Zhao, Hao Ma,

Zhelu Gao

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136163 - 136163

Published: Oct. 13, 2024

Language: Английский

Citations

3
Effects of AI-2 quorum sensing related luxS gene on Streptococcus suis formatting monosaccharide metabolism-dependent biofilm DOI
Shuji Gao, Shuo Yuan,

Yingying Quan

et al.

Archives of Microbiology, Journal Year: 2024, Volume and Issue: 206(10)

Published: Sept. 19, 2024

Language: Английский

Citations

2