Nitrogen source orchestrates pH modulation and secondary metabolism in Trichoderma harzianum
Chemical and Biological Technologies in Agriculture,
Год журнала:
2025,
Номер
12(1)
Опубликована: Фев. 4, 2025
Язык: Английский
Plant Growth-Promoting Microorganisms: new insights and the way forward
Microbiological Research,
Год журнала:
2025,
Номер
unknown, С. 128168 - 128168
Опубликована: Апрель 1, 2025
Язык: Английский
Prediction of secreted uncharacterized protein structures from Beauveria bassiana ARSEF 2860 unravels novel toxins-like families
Scientific Reports,
Год журнала:
2025,
Номер
15(1)
Опубликована: Май 22, 2025
Abstract
Insecticides
are
toxic
substances
used
to
control
a
wide
variety
of
agricultural
insect
pests.
Most
these
chemicals
in
nature,
and
their
increasing
residues
soil,
water,
fruits
contribute
environmental
pollution,
chronic
human
illnesses,
the
emergence
insecticide
resistance
phenomenon.
In
context
green
environment,
bioinsecticide
metabolites,
including
proteins,
safe
alternative
that
mostly
has
selective
toxicity
insects.
Thus,
this
study
aimed
predict
identify
new
toxin-like
families
through
uncharacterized
secreted
proteins
from
one
most
potent
entomopathogenic
fungi,
Beauveria
bassiana
ARSEF
2860,
which
was
selected
as
model.
work,
total
2483
amino
acid
sequences
(Ups)
were
retrieved
RefSeq
database.
Among
these,
365
UPs
identified
using
SignalP
web
server.
We
implemented
integration
well-designed
bioinformatic
tools
characterize
anticipate
homologous
similarities
at
sequence
(InterPro)
structural
(AlphaFold2)
levels.
The
function
annotation
predicted
DeepFRI.
With
269
successfully
folds,
we
putative
with
pathogenesis
functions
related
toxins
like
Janus-faced
atracotoxins
(insecticidal
spider
toxin),
Cry
(commercial
Bacillus
thuringiensis
),
ARTs-like
toxins,
other
insecticidal
toxins.
Furthermore,
some
not
any
known
experimental
data
functionally
cation
metal
ion
binding
(Zn,
Na,
Co)
potential
toxicity.
Collectively,
computational
genomics
can
be
host–pathogen
interactions
novel
families.
Язык: Английский
A synthetic platform for multiplex screening of cell-cell communication between soil fungi
bioRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 30, 2024
Fungi
are
essential
members
across
ecosystems
yet
also
pose
significant
risks
to
crops
and
human
health.
To
thrive
in
microbial
consortia,
a
fungal
organism
must
integrate
the
perception
of
both
inter-
intra-species
signals.
Here
we
present
Yeast
Mating
Platform
(YeMaP)
decipher
cell-cell
communication
based
on
G
protein-coupled
receptors
(GPCRs)
pheromone
peptides.
We
use
YeMaP
investigate
influence
abiotic
factors
multiplex
for
high-throughput
screening
sequences
identify
peptides
with
improved
potency
or
antagonism
action.
Additionally,
demonstrate
that
plant
pathogen
Fusarium
oxysporum
GPCR-pheromone
interaction
is
robust
conditions,
it
can
be
disrupted
by
supplementation
promote
non-pathogenic
GPCRs
consortia.
Taken
together,
useful
tool
deciphering
complexity
GPCR-based
guiding
design
future
crop
pest-
disease-management
programs.
Язык: Английский