Design, synthesis, and evaluation of carboxylic acid-substituted celecoxib isosteres as potential anti-inflammatory agents
European Journal of Medicinal Chemistry,
Год журнала:
2025,
Номер
286, С. 117286 - 117286
Опубликована: Янв. 17, 2025
Язык: Английский
Theabrownin, gut microbiota, and obesity: Effects and mechanisms
Food Bioscience,
Год журнала:
2024,
Номер
unknown, С. 105381 - 105381
Опубликована: Окт. 1, 2024
Язык: Английский
Effects of gut microbiota and metabolites on the host defense peptide expression
Applied Microbiology and Biotechnology,
Год журнала:
2025,
Номер
109(1)
Опубликована: Янв. 18, 2025
The
widespread
use
of
antibiotics
has
led
to
the
emergence
multidrug-resistant
bacteria,
which
pose
significant
threats
animal
health
and
food
safety.
Host
defense
peptides
(HDPs)
have
emerged
as
promising
alternatives
because
their
unique
antimicrobial
properties
minimal
resistance
induction.
However,
high
costs
associated
with
HDP
production
incorporation
into
management
practices
hinder
application.
Alternatively,
promoting
endogenous
expression
gained
attention
a
sustainable
cost-effective
approach.
This
study
summarizes
latest
research
findings
on
modulation
by
gut
microbiota
its
metabolites.
By
exploring
intricate
relationships
among
microbiota,
metabolites,
expression,
this
aims
provide
theoretical
foundation
for
development
targeted
strategies
increase
production,
thereby
infectious
diseases.
KEY
POINTS:
•
are
expressed
via
various
factors,
such
nutrients,
microbial
Recent
trends
include
mechanisms
intestine
expression.
A
comprehensive
overview
microbiota-host
interaction
is
provided.
Язык: Английский
Dangua Fang induces anti-glucolipid metabolism disorder effects similar to those of direct NFIL3 inhibition
Frontiers in Microbiology,
Год журнала:
2025,
Номер
16
Опубликована: Март 19, 2025
Background
Dangua
Fang
(DGF)
is
a
traditional
Chinese
herbal
formula
widely
used
to
regulate
glucolipid
metabolism.
Nuclear
factor,
interleukin-3
regulated
(NFIL3)
plays
regulatory
role
in
intestinal
fat
absorption
and
energy
Gut
microbiota
can
modulate
NFIL3
expression
affect
host
Purpose
This
study
aimed
investigate
the
effects
of
DGF
or
inhibition
on
gut
their
metabolites
mice
with
metabolism
disorder
(GLMD)
explore
relationship
between
anti-GLMD
those
direct
inhibition.
Methods
A
GLMD
mouse
model
was
established
by
induction
high-glucose
high-fat
diet.
The
were
divided
into
control
group
(CG),
(MG),
(DFG),
+
siRNA
(DFSG),
(SG).
administered
sterile
water,
DGF,
and/or
intraperitoneal
injections
siRNA-NFIL3
normal
saline
for
15
weeks,
following
which
metabolic
indicators,
levels,
histopathological
alterations
liver
small
tissues
evaluated.
Additionally,
differential
analysed,
linear
regression
analysis
conducted
microbial
species
indicators
assess
regulation.
Results
Significant
differences
observed
CG
MG
groups
various
indicators.
Compared
that
group,
DFG,
DFSG,
SG
significantly
improved,
pathological
morphology
intestine
altered.
mRNA
protein
levels
serum,
liver,
decreased.
relative
abundance
Bacteroidota
decreased,
whereas
Firmicutes
increased,
changes
correlated
serum
total
cholesterol
(TC),
triglyceride
(TG),
free
fatty
acid
(FFA)
levels.
Moreover,
lipid
metabolism-related
pathways
altered
all
three
intervention
groups.
Conclusion
reduced
mice,
metabolites,
pathways,
similar
Язык: Английский
Anti-inflammatory diet or anti-inflammatory lifestyle?
David Mariani,
Sabrina Lucchetti
Giornale di Clinica Nefrologica e Dialisi,
Год журнала:
2025,
Номер
37(1), С. 10 - 15
Опубликована: Апрель 10, 2025
Chronic
low-grade
inflammation
is
increasingly
proving
to
be
one
of
the
main
culprits
for
onset
numerous
pathologies.
Until
recently,
try
combat
this
insidious
enemy,
we
mainly
resorted
anti-inflammatory
diets,
but
current
scientific
evidence
seems
support
hypothesis
that
maximum
impact
on
health
could
obtained
above
all
by
following
an
lifestyle.
Nutrition
alone,
however
important,
has
proven
insufficient
guarantee
physiological
homeostasis,
result
evolution
lasted
hundreds
thousands
years
and
occurred
in
symbiosis
with
ecosystems.
Our
conditions,
psychosocial
relationships
emotions
connected
them,
together
environment,
are
elements
capable
interacting
each
other,
decisively
influencing
inflammatory
process.
The
Healthy
Habits
approach
interprets
makes
thought
concrete,
and,
integrated
interdisciplinary
approach,
traces
a
viable
route.
Язык: Английский
Therapeutic Mechanism of Kynurenine, a Metabolite of Probiotics, on Atopic Dermatitis in Mice
Foods,
Год журнала:
2025,
Номер
14(10), С. 1816 - 1816
Опубликована: Май 20, 2025
Atopic
Dermatitis
(AD)
is
a
common
inflammatory
skin
disease
characterized
primarily
by
its
chronic
and
recurrent
nature.
This
has
significant
impact
on
productivity
human
longevity.
Dysbiosis
of
gut
flora
been
demonstrated
to
be
significantly
associated
with
the
progression
AD.
In
our
previous
research,
it
was
shown
that
Lactobacillus
rhamnosus
RL5-H3-005
(RL)
Pediococcus
acidilactici
RP-H3-006
(RP)
have
ability
reduce
risk
in
AD
mice
through
gut–mammary
axis.
Based
work,
this
study
aims
further
investigate
effects
kynurenine
(KYN),
metabolite
RL
RP,
induced
2,
4-dinitrofluorobenzene
(DNFB).
study,
we
found
supplementing
KYN
effectively
alleviates
pathological
symptoms
atopic
dermatitis
improves
levels
SCFAs
their
intestines.
Further
research
indicates
KYN’s
therapeutic
are
manifested
reduction
secretory
immunoglobulin
A
(sIgA),
E
(IgE),
interleukin-4
(IL-4),
IL-5,
IL-13,
thymic
stromal
lymphopoietin
(TSLP)
mice,
while
also
repairing
intestinal
barrier
function
mice.
Overall,
metabolites
probiotics
RP
can
regulate
potentially
improving
gut–skin
Язык: Английский
Salmonella: Infection mechanism and control strategies
Microbiological Research,
Год журнала:
2024,
Номер
292, С. 128013 - 128013
Опубликована: Дек. 12, 2024
Язык: Английский
Molecular mechanisms and therapeutic strategies of gut microbiota modulation in Sarcopenia (Review)
Oncology Letters,
Год журнала:
2024,
Номер
29(3)
Опубликована: Дек. 17, 2024
Sarcopenia
is
an
age-related
disease
that
characterized
by
a
decline
in
muscle
mass
and
function
with
significant
epidemiological
clinical
implications.
In
recent
years,
gut
microbiota
has
gained
attention
as
important
regulatory
factor
human
health.
To
the
best
of
our
knowledge,
this
first
study
to
introduce
definition
background
sarcopenia
analyze
potential
impact
on
metabolism
growth,
including
aspects
such
metabolites,
protein
synthesis
energy
metabolism.
Additionally,
article
summarizes
current
research
progress
interventions
for
treatment
sarcopenia,
probiotics,
prebiotics
fecal
transplantation
discusses
future
directions
therapeutic
strategies.
Язык: Английский
Free-caged rearing modes Regulate intestinal metabolism by influencing gut microbial homeostasis
Poultry Science,
Год журнала:
2024,
Номер
104(1), С. 104381 - 104381
Опубликована: Окт. 30, 2024
Язык: Английский
Dynamic Changes in Intestinal Microorganisms and Hematological Indices in Giraffes of Different Ages, and the Effect of Diarrhea on Intestinal Microbiota
Animals,
Год журнала:
2024,
Номер
14(23), С. 3379 - 3379
Опубликована: Ноя. 24, 2024
This
study
employed
high-throughput
sequencing
to
explore
bacterial
diversity
and
hematological
variations
across
different
age
groups
of
giraffes,
as
well
the
impact
diarrhea
on
their
intestinal
microbiota.
Additionally,
correlation
between
flora
indices
was
examined
for
first
time.
Firmicutes,
Bacteroides,
Proteobacteria
were
predominant
in
giraffe's
flora.
The
α-diversity
analysis
indicated
significant
microbial
among
giraffes
varying
ages
(
Язык: Английский