Gallstones in the Era of Metabolic Syndrome: Pathophysiology, Risk Prediction, and Management
Cureus,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 13, 2025
Gallstone
disease
(GSD)
and
metabolic
syndrome
(MetS)
are
increasingly
prevalent
conditions
with
significant
global
health
implications.
Recent
evidence
highlights
a
strong
epidemiological
association
between
these
disorders,
driven
by
shared
pathophysiological
mechanisms.
This
review
provides
comprehensive
analysis
of
the
intricate
relationship
MetS
GSD,
focusing
on
role
insulin
resistance,
dyslipidemia,
obesity,
gut
microbiota
dysbiosis
in
gallstone
formation.
An
integrated
model
is
proposed,
linking
disturbances
to
bile
cholesterol
supersaturation,
gallbladder
dysmotility,
chronic
inflammation.
The
also
explores
clinical
implications,
including
risk
prediction
models
based
parameters,
early
detection
biomarkers,
targeted
interventions
such
as
lifestyle
modifications,
pharmacological
therapies,
microbiome
modulation.
By
addressing
underpinnings
this
synthesis
offers
foundation
for
developing
preventive
therapeutic
strategies
mitigate
burden
interconnected
conditions.
Future
research
directions
outlined
refine
mechanistic
insights
improve
outcomes.
Язык: Английский
Crosstalk between bile acids and gut microbiota: a potential target for precancerous lesions of gastric cancer
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Март 13, 2025
As
a
critical
juncture
in
the
pathological
continuum
from
gastritis
to
gastric
cancer,
precancerous
lesions
of
cancer
(PLGC)
are
increasingly
prevalent,
significantly
undermining
health
global
population.
The
primary
constituents
bile,
specifically
bile
acids
(BAs),
disrupt
equilibrium
hormone
secretion
and
compromise
structural
integrity
mucosa,
thereby
facilitating
oncogenesis.
Moreover,
gut
microbiota
modulate
host
physiological
processes
through
immune
response
regulation,
metabolic
pathway
interference,
direct
interaction
with
tumor
cells.
Extensive
research
has
elucidated
that
dysregulation
BAs
microbiota,
concert
resultant
impairment
central
pathogenesis
PLGC.
In
anticipation
future
clinical
preventive
therapeutic
strategies,
this
review
collates
recent
insights
into
roles
bacteria
PLGC,
examining
their
interplay
significance
pathogenic
mechanism
Язык: Английский
Gut-lung Axis mediates asthma pathogenesis: Roles of dietary patterns and their impact on the gut microbiota
Experimental and Molecular Pathology,
Год журнала:
2025,
Номер
142, С. 104964 - 104964
Опубликована: Апрель 8, 2025
The
gut-lung
axis,
a
vital
signaling
network
linking
the
gastrointestinal
and
pulmonary
systems,
regulates
immune
responses
progression
of
respiratory
diseases.
Nutritional
components
can
modulate
gut
microbiome
regulate
synthesis
critical
intestinal
microbial
metabolites,
which
are
essential
for
maintaining
homeostasis
supporting
health.
Conversely,
poor
dietary
habits
exacerbate
asthma
other
conditions
through
modulation
systemic
inflammation
responses.
Dietary
interventions,
such
as
Mediterranean
diet,
reported
to
restore
balance
improve
health
by
increasing
production
anti-inflammatory
potentiating
responses,
preserving
epithelial
barrier
integrity.
In
contrast,
Western
patterns,
characterized
high
fat
low
fiber
intake,
disrupt
diversity,
resulting
in
increased
levels
pro-inflammatory
metabolites
that
aggravate
airway
severity.
This
review
aimed
elucidate
mechanisms
underlying
regulatory
effects
microbes
their
on
asthma.
Additionally,
previous
findings
related
axis
have
been
summarized,
providing
insights
into
potential
therapeutic
strategies
management.
Язык: Английский
Interplay between the gut microbiota, its metabolites and carcinogens
Clinical & Translational Oncology,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 13, 2025
Язык: Английский
Alleviation of Alcoholic Liver Injury through Composite Postbiotics Regulation of Intestinal Flora and Promotion of Bile Acid Metabolism
Qi Peng,
Kaiming Yang,
Qifan Hou
и другие.
Food Bioscience,
Год журнала:
2024,
Номер
unknown, С. 105379 - 105379
Опубликована: Окт. 1, 2024
Язык: Английский
Intermittent Fasting Improves Insulin Resistance by Modulating the Gut Microbiota and Bile Acid Metabolism in Diet‐Induced Obesity
Molecular Nutrition & Food Research,
Год журнала:
2024,
Номер
68(22)
Опубликована: Ноя. 1, 2024
Scope
Adipose
tissue
macrophages
(ATMs)
are
crucial
in
the
pathogenesis
of
insulin
resistance
(IR).
Intermittent
fasting
(IF)
is
an
effective
intervention
for
obesity.
However,
underlying
mechanism
by
which
IF
improves
IR
remains
unclear.
Methods
and
results
Male
C57BL/6J
mice
fed
chow‐diet
high‐fat
diet
(HFD)
12
weeks,
then
randomized
into
ad
libitum
feeding
or
every
other
day
8
weeks.
Markers
ATMs
expression
uncoupling
protein
1
(UCP‐1)
determined.
Gut
microbiota
bile
acids
(BAs)
profiled
using
16S
rRNA
sequencing
targeted
metabolomics
analysis.
Results
indicate
that
HFD‐induced
decreases
ATM
infiltration,
pro‐inflammatory
M1
gene
expression,
promotes
white
adipose
(WAT)
browning
elevating
UCP‐1
expression.
restructures
composition,
significantly
expanding
abundance
Verrucomicrobia
particularly
Akkermansia
muciniphila
,
with
decrease
Firmicutes
.
increases
level
total
BAs
alters
composition
higher
proportion
12α‐hydroxylated
(12α‐OH)
BAs.
The
changes
these
correlated
differential
bacteria.
Conclusion
findings
partially
mediated
interplay
between
restructured
gut
metabolism,
has
implications
dietary
management
Язык: Английский
Hepatoprotective, Lipid-Lowering and Antioxidant Effects of Mangaba Powder (Hancornia speciosa) Administered to Rats Fed a High-Fat Diet
Foods,
Год журнала:
2024,
Номер
13(23), С. 3773 - 3773
Опубликована: Ноя. 25, 2024
The
aim
of
this
study
was
to
evaluate
the
potential
effects
administering
mangaba
powder
on
liver
function
and
somatic,
oxidative
lipid
metabolism
parameters
in
rats
fed
a
high-fat
diet.
Prepared
has
important
amounts
phenolic
compounds,
vitamin
C,
dietary
fiber
oligosaccharides.
A
total
32
adult
Wistar
were
initially
randomized
into
two
groups
for
biological
assay:
normal-fat
(NF,
n
=
16)
(HF,
diets
21
days.
These
subsequently
subdivided
four
groups:
NF
(n
8),
HF
diet
with
administration
(NFMG,
8)
(HFMG,
8).
treatment
(400
mg/kg)
lasted
an
additional
28
Compared
rats,
HFMG
showed
8%
reduction
body
mass
index.
Treatment
reduced
serum
cholesterol
by
18%,
as
well
hepatic
deposition
triacylglycerides
26%
25%,
addition
increasing
bile
acid
synthesis
77%
organ.
Mangaba
consumption
attenuated
degree
steatosis,
peroxidation
increased
antioxidant
capacity
rats.
results
show
that
had
lipid-lowering,
hepatoprotective
effects,
especially
which
may
be
associated
additive
synergistic
action
between
bioactive
compounds
present
product.
Язык: Английский
An Insightful Comparison of The Current Neuroimmune Mechanism(s) with the Thoughts of Differential Syndromes from Traditional Chinese Medicine for the Treatment of MDD
Brain Behavior and Immunity Integrative,
Год журнала:
2024,
Номер
unknown, С. 100100 - 100100
Опубликована: Дек. 1, 2024
Язык: Английский