Journal of The Electrochemical Society,
Год журнала:
2024,
Номер
171(7), С. 077505 - 077505
Опубликована: Июль 1, 2024
In
the
pharmaceutical
field,
analytical
chemistry
is
evolving
and
one
area
that
experiencing
enthusiasm
design
implementation
of
solid
contact
ion-selective
electrodes.
We
have
developed
two
potentiometric
sensors
for
selective
assay
a
widely
used
drug
diclofenac
sodium.
Diclofenac
sodium
was
targeted
in
its
most
recommended
dosage
forms
(Arthrotec
®
tablets)
presence
misoprostol.
A
cost-effective
copper
printed
circuit
board
as
substrate
has
been
coated
with
PVC
sensing
membrane
to
fabricate
sensor
I.
Hydrophobic
carbon
nanotubes
(CNTs)
modified
through
situ
reduction
pentafluorophenyl
diazonium
using
borohydride.
An
interlayer
CNTs
inserted
transducer
layer
between
Cu
ion-sensing
II
enhance
electrochemical
performance
stability.
The
microfabricated
electrodes
demonstrated
encouraging
outcomes
upon
direct
combination
misoprostol
other
additives
without
sample
preparation
steps.
responses
presented
linear
Nernstian
pattern
range
1.0
×
10
−4
−2
mol
l
−1
slope
−58.2
−58.4
mV/decade
I
II,
consequently.
Finally,
sustainability
technique
assured
advanced
green
metrics.
Journal of Chromatographic Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 26, 2024
Abstract
Nowadays,
there
is
a
strong
interest
in
the
scientific
community
developing
innovative
methodologies
within
green
analytical
chemistry
framework.
Herein,
we
introduce
first
chromatographic
approaches
for
concurrent
estimation
of
paracetamol
(PAR),
carbinoxamine
(CRX),
and
pseudoephedrine
(PSE)
intended
to
relieve
COVID-19
common
cold
symptoms.
The
method
was
thin
layer
chromatography
(TLC)
densitometry,
which
depends
on
separation
studied
medications
TLC
silica
gel
plates
using
ethyl
acetate:
methanol:
ammonia
(7.0:
3.0:
0.2,
by
volume)
as
system,
were
scanned
at
208.0
nm.
data
linear
ranges
1–25
μg/band
PAR,
PSE
0.1–5
CRX.
second
reversed-phase
high-performance
liquid
Kromasil
C18
column
mixture
0.01
M
phosphate
buffer
containing
0.1%
triethylamine
(pH
3.5)
adjusted
with
orthophosphoric
acid
ethanol
flow
rate
1.0
mL/min
gradient
program.
separated
peaks
detected
215.0
nm
over
concentration
range
10–250
μg/mL
5–35
PSE,
0.5–25
Both
validated
according
International
Conference
Harmonization
(ICH)
guidelines.
Finally,
impact
these
methods
environment
evaluated
many
tools.
Journal of The Electrochemical Society,
Год журнала:
2024,
Номер
171(7), С. 077505 - 077505
Опубликована: Июль 1, 2024
In
the
pharmaceutical
field,
analytical
chemistry
is
evolving
and
one
area
that
experiencing
enthusiasm
design
implementation
of
solid
contact
ion-selective
electrodes.
We
have
developed
two
potentiometric
sensors
for
selective
assay
a
widely
used
drug
diclofenac
sodium.
Diclofenac
sodium
was
targeted
in
its
most
recommended
dosage
forms
(Arthrotec
®
tablets)
presence
misoprostol.
A
cost-effective
copper
printed
circuit
board
as
substrate
has
been
coated
with
PVC
sensing
membrane
to
fabricate
sensor
I.
Hydrophobic
carbon
nanotubes
(CNTs)
modified
through
situ
reduction
pentafluorophenyl
diazonium
using
borohydride.
An
interlayer
CNTs
inserted
transducer
layer
between
Cu
ion-sensing
II
enhance
electrochemical
performance
stability.
The
microfabricated
electrodes
demonstrated
encouraging
outcomes
upon
direct
combination
misoprostol
other
additives
without
sample
preparation
steps.
responses
presented
linear
Nernstian
pattern
range
1.0
×
10
−4
−2
mol
l
−1
slope
−58.2
−58.4
mV/decade
I
II,
consequently.
Finally,
sustainability
technique
assured
advanced
green
metrics.
