Frontiers in Psychiatry,
Год журнала:
2018,
Номер
9
Опубликована: Авг. 6, 2018
Background:
Childhood
sexual
abuse
(CSA)
is
a
prevalent
subtype
of
early
life
stress
associated
with
changes
in
immunological
and
neuroendocrine
systems
leading
to
inflammatory
responses
the
organism
increasing
several
immune
markers.
We
aimed
conduct
systematic
review
concerning
association
between
CSA
indicators
activity.
Methods:
conducted
search
for
articles
PubMed,
Scopus,
PsycINFO,
Web
Science,
using
key
words:
("Child
abuse"
OR
"childhood
maltreatment"
"sexual
violence"
"posttraumatic
disorder"
"rape")
AND
("cytokines"
"inflammatory
markers"
"interleukin"
"tumor
necrosis
factor"
"C-reactive
protein").
PRISMA
guidelines
were
used
order
improve
quality
this
research,
MeSH
terms
PubMed.
Results:
A
total
3,583
studies
found
and,
after
application
exclusion
criteria,
17
included
review.
Most
reported
an
increase
activity
presence
abuse.
IL-6,
TNF-
α,
C-reactive
protein
most
frequently
analyzed
markers
some
showed
higher
levels
individuals
that
suffered
compared
controls,
although
results
heterogeneous,
as
was
assessment
CSA,
repeated
trauma,
time
occurrence.
It
not
possible
perform
meta-analysis
because
diversified.
Conclusion:
levels.
Improving
subtypes
trauma
important
further
understand
complex
correlations
its
biological
consequences
such
psychiatric
physical
illness
later
life.
Abstract
While
biological
alterations
associated
with
childhood
maltreatment
(CM)
have
been
found
in
affected
individuals,
it
remains
unknown
to
what
degree
these
are
biologically
transmitted
the
next
generation.
We
investigated
intergenerational
effects
of
maternal
CM
on
DNA
methylation
and
gene
expression
N
=
113
mother-infant
dyads
shortly
after
parturition,
additionally
accounting
for
role
FKBP5
rs1360780
genotype.
Using
mass
array
spectrometry,
we
assessed
selected
stress-response-associated
genes
(FK506
binding
protein
51
[
],
glucocorticoid
receptor
NR3C1
corticotropin-releasing
hormone
1
CRHR1
])
isolated
immune
cells
from
blood
neonatal
umbilical
cord
blood.
In
mothers,
was
decreased
levels
increased
methylation,
but
not
changes
profiles.
Rs1360780
moderated
epigenetic
CM-associated
regulation
profiles
a
×
environment
interaction.
newborns,
no
evidence
any
transmission
CM-related
sites.
These
findings
support
hypothesis
long-lasting
impact
stress-response
mediators
suggest
first
time
that
specific
patterns
might
be
directly
PLoS ONE,
Год журнала:
2021,
Номер
16(4), С. e0243685 - e0243685
Опубликована: Апрель 8, 2021
Introduction
Child
maltreatment
(CM)
is
associated
with
mental
and
physical
health
disorders
in
adulthood.
Some
studies
have
identified
elevated
markers
of
systemic
inflammation
adult
survivors
CM,
may
mediate
the
association
between
CM
later
problems.
However,
there
are
methodological
inconsistencies
findings
conflicting.
We
performed
a
systematic
review
to
examine
adults.
Methods
A
pre-registered
was
following
PRISMA
guidelines.
Medline,
Embase,
Scopus
PsychInfo
were
searched
for
blood
Quality
assessed
using
Crowe
Critical
Appraisal
Tool.
had
intended
perform
meta-analysis,
but
this
not
possible
due
variation
study
design
reporting.
Results
Forty-four
articles
met
criteria
inclusion
review.
The
most
widely
reported
biomarkers
C-Reactive
Protein
(CRP)
(n
=
27),
interleukin-6
(IL-6)
24)
Tumour
Necrosis
Factor-alpha
(TNF-a)
17).
Three
prospective
(all
relating
CRP)
remainder
retrospective.
86%
based
high
income
countries.
In
studies,
CRP
retrospective
Methodological
issues
construct
methods
analysis,
accounting
confounding
or
mediating
variables
(particularly
Body
Mass
Index)
contribute
uncertainty
field.
Conclusions
There
some
robust
evidence
from
that
significant
literature
proposed
measures
future
researchers
could
employ
improve
consistency
across
studies.
Further
prospective,
longitudinal,
research
comparable
careful
consideration
required
bring
clarity
Frontiers in Psychiatry,
Год журнала:
2018,
Номер
9
Опубликована: Авг. 6, 2018
Background:
Childhood
sexual
abuse
(CSA)
is
a
prevalent
subtype
of
early
life
stress
associated
with
changes
in
immunological
and
neuroendocrine
systems
leading
to
inflammatory
responses
the
organism
increasing
several
immune
markers.
We
aimed
conduct
systematic
review
concerning
association
between
CSA
indicators
activity.
Methods:
conducted
search
for
articles
PubMed,
Scopus,
PsycINFO,
Web
Science,
using
key
words:
("Child
abuse"
OR
"childhood
maltreatment"
"sexual
violence"
"posttraumatic
disorder"
"rape")
AND
("cytokines"
"inflammatory
markers"
"interleukin"
"tumor
necrosis
factor"
"C-reactive
protein").
PRISMA
guidelines
were
used
order
improve
quality
this
research,
MeSH
terms
PubMed.
Results:
A
total
3,583
studies
found
and,
after
application
exclusion
criteria,
17
included
review.
Most
reported
an
increase
activity
presence
abuse.
IL-6,
TNF-
α,
C-reactive
protein
most
frequently
analyzed
markers
some
showed
higher
levels
individuals
that
suffered
compared
controls,
although
results
heterogeneous,
as
was
assessment
CSA,
repeated
trauma,
time
occurrence.
It
not
possible
perform
meta-analysis
because
diversified.
Conclusion:
levels.
Improving
subtypes
trauma
important
further
understand
complex
correlations
its
biological
consequences
such
psychiatric
physical
illness
later
life.
