Sinisan alleviates depression-like behaviors by regulating mitochondrial function and synaptic plasticity in maternal separation rats

Phytomedicine, Год журнала: 2022, Номер 106, С. 154395 - 154395

Опубликована: Авг. 23, 2022

Sinisan (SNS) consists of four kinds herbs, which is the core antidepressant prescription widely used in traditional Chinese medicine clinic treatment for depression induced by early life stress. However, role and precise mechanism SNS have not yet been elucidated.This study aimed to investigate on regulating mitochondrial function improve hippocampal synaptic plasticity.90 Sprague-Dawley (SD) rats male pups Post-Natal Day (PND) 0 were randomly divided into Control group (ddH20), Model Fluoxetine (5.0 mg/kg fluoxetine), SNS-L (2.5 g/kg SNS), SNS-M SNS) SNS-H (10.0 15 animals per group. Maternal separation (MS) from PND1 PND21, drug intervention PND60 PND90, behavior tests including sucrose preference test, open field test forced swimming PND83 PND90 performed. Synaptic structure observed TEM. The expression levels PSD-95 SYN detected immunohistochemistry western blot adenosine triphosphate (ATP) content hippocampus was assay kits, Mfn2, Drp1 Fis1 protein bolt test.SNS can alleviate depression-like anxiety-like behaviors MS rats, damage synapses mitochondria, reduce decrease ATP hippocampus, reverse PSD-95, SYN, Drp1, proteins.SNS reduced risk stress disorder via plasticity. Targeting may be a novel prospective therapeutic avenue antidepressant.

Язык: Английский

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The Stress Phenotyping Framework: A multidisciplinary biobehavioral approach for assessing and therapeutically targeting maladaptive stress physiology

Stress, Год журнала: 2024, Номер 27(1)

Опубликована: Май 6, 2024

Although dysregulated stress biology is becoming increasingly recognized as a key driver of lifelong disparities in chronic disease, we presently have no validated biomarkers toxic physiology; biological, behavioral, or cognitive treatments specifically focused on normalizing processes; and agreed-upon guidelines for treating the clinic evaluating efficacy interventions that seek to reduce improve human functioning. We address these critical issues by (a) systematically describing systems mechanisms are stress; (b) summarizing indicators, biomarkers, instruments assessing response systems; (c) highlighting therapeutic approaches can be used normalize stress-related biopsychosocial also present novel multidisciplinary Stress Phenotyping Framework bring researchers clinicians one step closer realizing goal using precision medicine-based prevent treat stress-associated health problems.

Язык: Английский

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Childhood adverse life events and skeletal muscle mitochondrial function

Science Advances, Год журнала: 2024, Номер 10(10)

Опубликована: Март 6, 2024

Social stress experienced in childhood is associated with adverse health later life. Mitochondrial function has been implicated as a mechanism for how stressful life events "get under the skin" to influence physical well-being. Using data from Study of Muscle, Mobility, and Aging (

Язык: Английский

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Ripple Effects of Early Life Stress on Vascular Health

Hypertension, Год журнала: 2025, Номер unknown

Опубликована: Янв. 30, 2025

The term early life stress encompasses traumatic events occurring before the age of 18 years, such as physical abuse, verbal household dysfunctions, sexual childhood neglect, child maltreatment, and adverse experiences. Adverse psychological experiences in are linked to enduring effects on mental health adulthood. In this review, we first describe potential mechanisms components vasculature. Next, dive into impact vasculature across lifespan through alterations epigenetic landscape. Finally, consolidate critical gaps knowledge for focusing future research including resilience combatting vascular health.

Язык: Английский

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Exploring the interplay between mitochondrial dysfunction, early life adversity and bipolar disorder

International Journal of Psychiatry in Clinical Practice, Год журнала: 2025, Номер unknown, С. 1 - 7

Опубликована: Март 14, 2025

Mitochondria are essential for energy production and reactive oxygen species (ROS) generation, with changes in ROS levels or demands affecting mitochondrial DNA (mtDNA) copy numbers, indicating function. Early life adversity (ELA) affects dynamics, influencing long-term health. Both ELA abnormalities have been independently associated bipolar disorder (BD). This study aims to explore the complex interplay between dysfunction, ELA, BD. The included 60 participants diagnosed BD 66 healthy controls (HCs). Data were collected using Childhood Trauma Questionnaire (CTQ), leukocyte mtDNA number (MCN) was determined from blood samples. results indicated CTQ sum scores significantly higher group, reflecting greater exposure ELA. In HCs, a marginally significant nonlinear relationship square of score MCN found. Further analysis demonstrated interaction on (p = 0.023), highlighting critical connection dysfunction reinforcing its biological underpinnings. Future treatments might target dysfunctions related chronic stress, potential pharmaceuticals designed address these issues mitigate negative effects stress.

Язык: Английский

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Effects of early-life stress on peripheral and central mitochondria in male mice across ages

Psychoneuroendocrinology, Год журнала: 2021, Номер 132, С. 105346 - 105346

Опубликована: Июнь 29, 2021

Exposure to early-life stress (ES) increases the vulnerability develop metabolic diseases as well cognitive dysfunction, but specific biological underpinning of ES-induced programming is unknown. Metabolic and disorders are often comorbid, suggesting possible converging underlying pathways. Mitochondrial dysfunction implicated in both chronic impairs mitochondrial functioning. However, if how mitochondria impacted by ES whether they remains be determined. was applied providing mice with limited nesting bedding material from postnatal day (P)2-P9, parameters, functions multiple aspects biology (i.e. electron transport chain (ETC) complex activity, DNA copy number, expression genes relevant for function, antioxidant capacity) were studied muscle, hypothalamus hippocampus at P9 late adulthood (10-12 months age). We show that altered bodyweight (gain), adiposity glucose levels P9, not adulthood. At this age, however, exposure led impairments. affected peripheral central an age-dependent manner. muscle hypothalamic ETC activity ES, while hippocampus, involved fission defence. In adulthood, alterations observed specifically, whereas mitophagy fission, respectively. Our study demonstrates affects throughout life, thereby uncovering a mechanism might contribute which could serve novel target intervention.

Язык: Английский

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Is early life adversity a trigger towards inflammageing?

Experimental Gerontology, Год журнала: 2021, Номер 150, С. 111377 - 111377

Опубликована: Апрель 24, 2021

Язык: Английский

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Antidepressants that increase mitochondrial energetics may elevate risk of treatment-emergent mania

Molecular Psychiatry, Год журнала: 2022, Номер 28(3), С. 1020 - 1026

Опубликована: Дек. 13, 2022

Preclinical evidence suggests that antidepressants (ADs) may differentially influence mitochondrial energetics. This study was conducted to investigate the relationship between function and illness vulnerability in bipolar disorder (BD), specifically risk of treatment-emergent mania (TEM). Participants with BD already clinically phenotyped as TEM+ (n = 176) or TEM- 516) were further classified whether TEM associated AD, based on preclinical studies, increased (Mito+, n 600) decreased (Mito-, 289) electron transport chain (ETC) activity. Comparison rates Mito+ Mito- ADs performed using generalized estimating equations account for participants exposed multiple while adjusting sex, age at time enrollment into biobank type (BD-I/schizoaffective vs. BD-II). A total 692 subjects (62.7% female, 91.4% White, mean 43.0 ± 14.0 years) including 176 cases (25.3%) 516 (74.7%) previous exposure and/or identified. Adjusting age, sex subtype, more frequent (24.7%), versus (13.5%) energetics (OR 2.21; p 0.000009). Our preliminary retrospective data there be merit reconceptualizing AD classification, not solely monoaminergic conventional drug mechanism action, but additionally Future prospective clinical studies specific activity are encouraged. Recognizing pharmacogenomic investigation response extend overlap genomics disease risk, future should potential interactions mechanisms response.

Язык: Английский

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Biological and behavioral pathways from prenatal depression to offspring cardiometabolic risk: Testing the developmental origins of health and disease hypothesis.

Developmental Psychology, Год журнала: 2024, Номер 60(9), С. 1620 - 1638

Опубликована: Фев. 15, 2024

Given prior literature focused on the Developmental Origins of Health and Disease framework, there is strong rationale to hypothesize that reducing depression in prenatal period will cause improvements offspring cardiometabolic health. The current review outlines evidence associated with risk health behaviors. We these associations humans nonhuman animals at multiple developmental periods, from (maternal preeclampsia, gestational diabetes), neonatal (preterm birth, small size birth), infancy (rapid weight gain), childhood adolescence (high blood pressure, impaired glucose-insulin homeostasis, unfavorable lipid profiles, abdominal obesity), into adulthood (diabetes, cardiovascular disease). In addition outcomes, we focus behaviors risk, such as child eating behaviors, diet, physical activity, sleep Our focuses (e.g., emotional eating, preference for highly palatable foods, short duration) parenting pressuring eat, modeling behaviors). These changes may be detected before which allow early identification prevention children poor adult outcomes. also discuss methods ongoing Care Project, a randomized clinical trial test whether maternal improves offspring's preschool. goal this Project are inform future research, interventions, policies support mental (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Язык: Английский

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Early life adversity is associated with differential gene expression in immune cells: A cluster-based analysis across an acute psychosocial stressor

Brain Behavior and Immunity, Год журнала: 2024, Номер 119, С. 724 - 733

Опубликована: Апрель 23, 2024

Язык: Английский

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