The Receptors, Год журнала: 2025, Номер unknown, С. 19 - 60
Опубликована: Янв. 1, 2025
Язык: Английский
Cancers, Год журнала: 2023, Номер 15(15), С. 3837 - 3837
Опубликована: Июль 28, 2023
The genomics-based concept of precision medicine began to emerge following the completion Human Genome Project. In contrast evidence-based medicine, will allow doctors and scientists tailor treatment different subpopulations patients who differ in their susceptibility specific diseases or responsiveness therapies. current model was proposed precisely classify into subgroups sharing a common biological basis for more effective tailored achieve improved outcomes. Precision has become term that symbolizes new age medicine. this review, we examine history, development, future perspective We also discuss concepts, principles, tools, applications related fields. our view, work, two essential objectives need be achieved. First, classified various subtypes. Second, targeted therapies must available each disease subtype. Therefore, focused review on progress meeting these objectives.
Язык: Английский
Процитировано
126
Pharmaceutics, Год журнала: 2024, Номер 16(3), С. 332 - 332
Опубликована: Фев. 27, 2024
The landscape of medical treatments is undergoing a transformative shift. Precision medicine has ushered in revolutionary era healthcare by individualizing diagnostics and according to each patient’s uniquely evolving health status. This groundbreaking method tailoring disease prevention treatment considers individual variations genes, environments, lifestyles. goal precision target the “five rights”: right patient, drug, time, dose, route. In this pursuit, silico techniques have emerged as an anchor, driving forward making realistic promising avenue for personalized therapies. With advancements high-throughput DNA sequencing technologies, genomic data, including genetic variants their interactions with other environment, can be incorporated into clinical decision-making. Pharmacometrics, gathering pharmacokinetic (PK) pharmacodynamic (PD) mathematical models further contribute drug optimization, behavior prediction, drug–drug interaction identification. Digital health, wearables, computational tools offer continuous monitoring real-time data collection, enabling adjustments. Furthermore, incorporation extensive datasets tools, such electronic records (EHRs) omics also another pathway acquire meaningful information field. Although they are fairly new, machine learning (ML) algorithms artificial intelligence (AI) resources researchers use analyze big develop predictive models. review explores interplay these multiple approaches advancing fostering healthcare. Despite intrinsic challenges, ethical considerations, protection, need more comprehensive research, marks new patient-centered Innovative hold potential reshape future generations come.
Язык: Английский
Процитировано
85
Cancers, Год журнала: 2023, Номер 15(13), С. 3474 - 3474
Опубликована: Июль 3, 2023
Non-small cell lung cancer (NSCLC) is a significant public health concern with high mortality rates. Recent advancements in genomic data, bioinformatics tools, and the utilization of biomarkers have improved possibilities for early diagnosis, effective treatment, follow-up NSCLC. Biomarkers play crucial role precision medicine by providing measurable indicators disease characteristics, enabling tailored treatment strategies. The integration big data artificial intelligence (AI) further enhances potential personalized through advanced biomarker analysis. However, challenges remain impact new on efficacy due to limited evidence. Data analysis, interpretation, adoption approaches clinical practice pose additional emphasize technologies such as analysis (AI), which enhance Despite these obstacles, into has shown promising results NSCLC, improving patient outcomes targeted therapies. Continued research discovery, utilization, evidence generation are necessary overcome medicine. Addressing obstacles will contribute continued improvement non-small cancer.
Язык: Английский
Процитировано
47
International Medical Science Research Journal, Год журнала: 2024, Номер 4(4), С. 509 - 520
Опубликована: Апрель 20, 2024
This review delves into Information Technology's (IT) transformative impact on precision medicine and genomics, spotlighting the pivotal role of bioinformatics, data mining, machine learning, blockchain technologies in advancing personalized healthcare. A comprehensive analysis outlines how these IT-enabled approaches facilitate analysis, interpretation, application vast genomic sets, thereby enhancing disease prediction, diagnosis, treatment an individual level. Despite promising advancements, also addresses significant challenges, including complexity, interoperability, ethical considerations, digital divide, underscoring necessity for multidisciplinary collaboration innovation to overcome hurdles. The paper concludes by emphasizing potential emerging patient-centred care realizing vision medicine, which promises improved healthcare outcomes through strategies. Keywords: Precision Medicine, Genomics, Bioinformatics, Machine Learning, Data Security.
Язык: Английский
Процитировано
27
Environmental Toxicology and Chemistry, Год журнала: 2023, Номер 43(3), С. 653 - 663
Опубликована: Янв. 17, 2023
Abstract The present study reviews options for reducing harm from pharmaceuticals that are known to cause adverse impacts by their presence in the environment. It recent global and European Union policy development, which could go further recognizing addressing issue a context. considers green chemistry, can help clean up production processes but holds only long‐term promise creating “green” alternatives. explores potential of health promotion disease prevention, contribute significantly reduction burden thus need medicines, both infectious noncommunicable disease. Eco‐directed sustainable prescribing practices reviewed, have been adopted successfully reduce use harmful pharmaceuticals. We note developments medicines optimization precision medicine, hold improving patient outcomes, saving costs, pharmaceutical use, through individually tailored whereby codecides therapy. Waste prevention reuse or redistribution is beginning find public support “take‐back” waste disposal schemes set via extended producer responsibility systems achieved high returns. Finally, paper summarizes preferred advanced wastewater technologies, including innovative low‐cost, low‐energy options. In summary, although end‐of‐pipe role play, particularly highly concentrated wastewaters, solutions medicinal chain interventions, informed broad view care, needed pursue much greater environment than be alone. Environ Toxicol Chem 2024;43:653–663. © 2023 Authors. Environmental Toxicology Chemistry published Wiley Periodicals LLC on behalf SETAC.
Язык: Английский
Процитировано
37
npj Digital Medicine, Год журнала: 2024, Номер 7(1)
Опубликована: Июнь 3, 2024
Abstract Digital twins represent a promising technology within the domain of precision healthcare, offering significant prospects for individualized medical interventions. Existing systematic reviews, however, mainly focus on technological dimensions digital twins, with limited exploration their impact health-related outcomes. Therefore, this review aims to explore efficacy in improving healthcare at population level. The literature search study encompassed PubMed, Embase, Web Science, Cochrane Library, CINAHL, SinoMed, CNKI, and Wanfang Database retrieve potentially relevant records. Patient outcomes were synthesized employing quantitative content analysis, whereas Joanna Briggs Institute (JBI) scales used evaluate quality potential bias inherent each selected study. Following established inclusion exclusion criteria, 12 studies screened from an initial 1321 records further analysis. These included patients various conditions, including cancers, type 2 diabetes, multiple sclerosis, heart failure, qi deficiency, post-hepatectomy liver dental issues. coded three types interventions: personalized health management, individual therapy effects, predicting risk, leading total 45 being measured. collective effectiveness these level was calculated 80% (36 out 45). No exhibited unacceptable differences quality. Overall, demonstrates practical advantages, warranting its expanded use facilitate transition development phase broad application. PROSPERO registry: CRD42024507256.
Язык: Английский
Процитировано
15
Frontiers in Pharmacology, Год журнала: 2024, Номер 15
Опубликована: Янв. 19, 2024
The global burden of cancer continues to rise, underscoring the urgency developing more effective and precisely targeted therapies. This comprehensive review explores confluence precision medicine CDC25 phosphatases in context research. Precision medicine, alternatively referred as customized aims customize medical interventions by taking into account genetic, genomic, epigenetic characteristics individual patients. identification particular genetic molecular drivers driving helps both diagnostic accuracy treatment selection. utilizes sophisticated technology such genome sequencing bioinformatics elucidate differences that underlie proliferation cells, hence facilitating development therapeutic interventions. phosphatases, which play a crucial role governing progression cell cycle, have garnered significant attention potential targets for treatment. dysregulation is characteristic feature observed various types malignancies, classifying them proto-oncogenes. proteins question, operate activation Cyclin-dependent kinases (CDKs), so promoting advancement cycle. inhibitors demonstrate drugs specifically blocking activity CDKs modulating cycle malignant cells. In brief, presents potentially fruitful option augmenting research, diagnosis, treatment, with an emphasis on individualized care predicated upon patients’ profiles. highlights significance identifies promising candidates intervention. statement underscores doing thorough profiling order uncover complex
Язык: Английский
Процитировано
10
Critical Reviews in Food Science and Nutrition, Год журнала: 2025, Номер unknown, С. 1 - 18
Опубликована: Фев. 5, 2025
Personalized nutrition (PN) delivers tailored dietary guidance by integrating health, lifestyle, and behavioral data to improve individual health outcomes. Recent technological advances have enhanced access diverse sources, yet challenges remain in collecting, integrating, analyzing complex datasets. To address these, the Nutrition Initiative at Illinois organized a workshop titled "Personalized Data: Challenges & Opportunities," which gathered experts explore three essential domains PN: 1) biological, 2) social, behavioral, environmental, 3) consumer purchasing data. Discussions underscored importance of cross-disciplinary collaboration standardize collection, enable secure sharing, develop fusion techniques that respect privacy build trust. Participants emphasized need for representative datasets include underserved populations, ensuring PN services are accessible equitable. Key principles responsible integration were proposed, alongside strategies overcome barriers effective use. By addressing these challenges, can enhance outcomes through precise, personalized recommendations population needs.
Язык: Английский
Процитировано
1
Chemical Biology Letters, Год журнала: 2024, Номер 11(2), С. 662 - 662
Опубликована: Апрель 18, 2024
Antimicrobial resistance (AMR) poses a significant threat to global health. It makes treating bacterial infections increasingly difficult. AMR arises from various mechanisms of antibiotic including enzymatic inactivation, target alteration, efflux pumps, and decreased permeability. The limited often ineffective treatments relying on antibiotics their combinations result in increased morbidity mortality. Therefore, it is essential explore alternative methods for combating the challenge AMR. In recent years, there has been notable shift towards precision medicine battle against Precision medicine, characterized by its focus individualized treatment tailored patients' specific genetic makeup, offers paradigm addressing challenges. By pinpointing molecular targets responsible infection, enables more targeted effective therapies, minimizing risk antimicrobial development. can provide an option combat focusing infection. Bacteriophages peptides (AMPs) are groups antimicrobials that serve as novel alternatives challenge. They have potential be used therapy. Despite challenges such host range, which refers bacteria they infect, regulatory concerns related approval usage, bacteriophages proven causing infections. Meanwhile, AMPs approach antibiotic-resistant due low weight broad-spectrum activity. first line defense microorganisms. When alone or combined with other biomaterials increase therapeutic action, This review article aims comprehensive overview current understanding clinical conventional pressing URN:NBN:sciencein.cbl.2024.v11.662
Язык: Английский
Процитировано
8
Frontiers in Medicine, Год журнала: 2024, Номер 11
Опубликована: Июль 18, 2024
In the relentless pursuit of precision medicine, intersection cutting-edge technology and healthcare has given rise to a transformative era. At forefront this revolution stands burgeoning field wearable implantable biosensors, promising paradigm shift in how we monitor, analyze, tailor medical interventions. As these miniature marvels seamlessly integrate with human body, they weave tapestry real-time health data, offering unprecedented insights into individual physiological landscapes. This log embarks on journey realm where convergence biology heralds new dawn personalized healthcare. Here, explore intricate web innovations, challenges, immense potential bioelectronics sentinels hold sculpting future medicine.
Язык: Английский
Процитировано
8