The bidirectional relationship between metabolism and cell cycle control

Trends in Cell Biology, Год журнала: 2023, Номер 34(2), С. 136 - 149

Опубликована: Июнь 27, 2023

Язык: Английский

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Pioneering the future of cancer therapy: Deciphering the p53-ferroptosis nexus for precision medicine

Cancer Letters, Год журнала: 2024, Номер 585, С. 216645 - 216645

Опубликована: Янв. 26, 2024

Язык: Английский

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Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cells

Nature Structural & Molecular Biology, Год журнала: 2024, Номер unknown

Опубликована: Июль 24, 2024

Язык: Английский

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Starvation signals in yeast are integrated to coordinate metabolic reprogramming and stress response to ensure longevity

Current Genetics, Год журнала: 2017, Номер 63(5), С. 839 - 843

Опубликована: Апрель 25, 2017

Studies on replicative and chronological aging in Saccharomyces cerevisiae have greatly advanced our understanding of how longevity is regulated all eukaryotes. Chronological lifespan (CLS) yeast defined as the age-dependent viability non-dividing cell populations. A number nutrient sensing signal transduction pathways (mainly TOR PKA) been shown to regulate CLS, yet it poorly understood starvation signals transduced via these lead CLS extension. Using reporters whose expressions are induced by glucose starvation, we screened majority 'signaling' mutants genome identified many genes that necessary for stress response. Subsequent analyses not only revealed novel regulators such GSK-3 ortholog Mck1, but also demonstrated transmitted SNF1/AMPK, PKC1 those negatively TOR/PKA, including Rim15, Yak1 Mck1 kinases, integrated enable metabolic reprogramming acquisition resistance. Coordinated ensures accumulation storage carbohydrates quiescent cells maintain viability. We provide new evidence Yak1, Rim15 kinases cooperate activate H2O2-scanvenging activities, thus limiting levels ROS entering quiescence. These findings support recent advances higher organisms flexibility balance between energetics resistance unifying principles Future work reveal switch response coordinated will help delineate molecular mechanisms shed insight into aging/anti-aging organisms.

Язык: Английский

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Targeted p53 on Small-Molecules-Induced Ferroptosis in Cancers

Frontiers in Oncology, Год журнала: 2018, Номер 8

Опубликована: Ноя. 2, 2018

Ferroptosis is a type of programmed cell death characterized by the accumulation lipid reactive oxygen species (L-ROS) driven oxidative degeneration lipids in an iron-dependent manner. The mechanism which degradation drives ROS-ferroptosis involves metabolic dysfunctions that result impaired intracellular processes and ROS production. Recent studies have found p53 acts as positive regulator ferroptosis promoting directly regulates versatility cells favoring mitochondrial respiration, leading to ROS-mediated ferroptosis. In mild stress, protects survival via eliminating ROS; additionally, human colorectal cancer, antagonizes formation DPP4–p53 complex. short, mechanisms p53-mediated production underlying cellular response are poorly understood. context recent research results, indistinct roles on scrutinized understand tumor suppression.

Язык: Английский

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Heat Oscillations Driven by the Embryonic Cell Cycle Reveal the Energetic Costs of Signaling

Developmental Cell, Год журнала: 2019, Номер 48(5), С. 646 - 658.e6

Опубликована: Фев. 1, 2019

Язык: Английский

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On the Molecular Mechanisms Regulating Animal Cell Size Homeostasis

Trends in Genetics, Год журнала: 2020, Номер 36(5), С. 360 - 372

Опубликована: Фев. 20, 2020

Язык: Английский

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G ₁ cyclin–Cdk promotes cell cycle entry through localized phosphorylation of RNA polymerase II

Science, Год журнала: 2021, Номер 374(6565), С. 347 - 351

Опубликована: Окт. 15, 2021

Control by RNA polymerase II Evidence indicates that yeast cells initiate DNA synthesis and transition from the G 1 to S phase of cell cycle when cyclin 3 accumulates causes phosphorylation Whi5, a functional equivalent mammalian Rb (retinoblastoma) protein. Kõivomägi et al . now present evidence for different cyclin-dependent kinase target (see Perspective Fisher). They found 3–cyclin-dependent (Cdk) complex in promoted thus increased transcription at genes control entry into cycle. Cdks regulate can act similar mechanisms so-called “transcriptional Cdks,” which are known as transcriptional regulators but not function division. —LBR

Язык: Английский

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The multifaceted role of cell cycle regulators in the coordination of growth and metabolism

FEBS Journal, Год журнала: 2020, Номер 288(12), С. 3813 - 3833

Опубликована: Окт. 8, 2020

Adapting to changes in nutrient availability and environmental conditions is a fundamental property of cells. This adaptation requires multi‐directional coordination between metabolism, growth, the cell cycle regulators (consisting family cyclin‐dependent kinases (CDKs), their regulatory subunits known as cyclins, CDK inhibitors, retinoblastoma members, E2F transcription factors). Deciphering mechanisms accountable for this crucial understanding various patho‐physiological processes. While it well established that metabolism growth affect division, review will focus on recent observations demonstrate how coordinate progression, growth. We discuss directly regulate metabolic enzymes pathways summarize involvement endolysosomal pathway functions dynamics mitochondria.

Язык: Английский

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Untargeted metabolomics links glutathione to bacterial cell cycle progression

Nature Metabolism, Год журнала: 2020, Номер 2(2), С. 153 - 166

Опубликована: Фев. 3, 2020

Язык: Английский

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