Molecular Biology of the Cell,
Год журнала:
2020,
Номер
31(10), С. 1069 - 1084
Опубликована: Май 1, 2020
In
several
systems,
including
budding
yeast,
cell
cycle-dependent
changes
in
the
transcriptome
are
well
studied.
contrast,
few
studies
queried
proteome
during
division.
There
is
also
little
information
about
dynamic
metabolites
and
lipids
cycle.
Here,
authors
present
such
for
dividing
yeast
cells.
Proceedings of the National Academy of Sciences,
Год журнала:
2020,
Номер
117(14), С. 7575 - 7583
Опубликована: Март 25, 2020
For
cells
to
replicate,
a
sufficient
supply
of
biosynthetic
precursors
is
needed,
necessitating
the
concerted
action
metabolism
and
protein
synthesis
during
progressive
phases
cell
division.
A
global
understanding
which
processes
are
involved
how
they
temporally
regulated
replication
is,
however,
currently
lacking.
Here,
quantitative
multiomics
analysis
used
generate
holistic
view
eukaryal
cycle,
using
budding
yeast
Saccharomyces
cerevisiae
Protein
central
carbon
pathways
such
as
glycolysis
amino
acid
shown
synchronize
their
respective
abundance
profiles
with
division,
pathway-specific
changes
in
metabolite
also
being
reflected
by
relative
increase
mitochondrial
volume,
fluorescence
microscopy.
These
results
show
precursor
production
be
meet
phase-specific
demands
Molecular Biology of the Cell,
Год журнала:
2020,
Номер
31(10), С. 1069 - 1084
Опубликована: Май 1, 2020
In
several
systems,
including
budding
yeast,
cell
cycle-dependent
changes
in
the
transcriptome
are
well
studied.
contrast,
few
studies
queried
proteome
during
division.
There
is
also
little
information
about
dynamic
metabolites
and
lipids
cycle.
Here,
authors
present
such
for
dividing
yeast
cells.