Nature Communications,
Год журнала:
2022,
Номер
13(1)
Опубликована: Авг. 10, 2022
Abstract
CDK4/6
inhibitors
(CDK4/6i)
and
oncolytic
viruses
are
promising
therapeutic
agents
for
the
treatment
of
various
cancers.
As
single
agents,
that
approved
breast
cancer
in
combination
with
endocrine
therapy
cause
G1
cell
cycle
arrest,
whereas
adenoviruses
induce
progression
into
S-phase
infected
cells
as
an
integral
part
their
life
cycle.
Both
adenovirus
replication
target
Retinoblastoma
protein
albeit
different
purposes.
Here
we
show
potentiate
anti-tumor
effect
XVir-N-31
bladder
murine
Ewing
sarcoma
xenograft
models.
This
increase
potency
correlates
virus-producing
cells,
enhanced
viral
genome
replication,
particle
formation
consequently
killing.
The
molecular
mechanism
regulates
this
response
is
fundamentally
based
on
reduction
expression
levels
by
inhibitors.
Cell Death and Differentiation,
Год журнала:
2022,
Номер
29(5), С. 946 - 960
Опубликована: Март 31, 2022
The
retinoblastoma
protein
RB
and
the
transcription
factor
p53
are
central
tumor
suppressors.
They
often
found
inactivated
in
various
types.
Both
proteins
play
roles
regulating
cell
division
cycle.
forms
complexes
with
E2F
family
of
factors
downregulates
numerous
genes.
Among
RB-E2F
target
genes,
a
large
number
code
for
key
cycle
regulators.
Their
transcriptional
repression
by
complex
is
released
through
phosphorylation
RB,
leading
to
expression
release
from
can
be
prevented
cyclin-dependent
kinase
inhibitor
p21/CDKN1A.
CDKN1A
gene
transcriptionally
activated
p53.
Taken
together,
these
elements
constitute
p53-p21-RB
signaling
pathway.
Following
activation
p53,
example
viral
infection
or
induction
DNA
damage,
p21
upregulated.
High
levels
then
result
formation
downregulation
Thus,
p53-dependent
indirect.
reduced
many
regulators
leads
arrest.
Examination
targets
genes
controlled
related
p53-p21-DREAM
pathway
reveals
that
there
overlap
two
groups.
Mechanistically
this
explained
replacing
DREAM
repressor
at
sites
promoters.
In
contrast
RB-E2F,
downregulate
also
CHR
binding
sites.
This
results
distinct
set
independent
RB-E2F.
Furthermore,
has
non-canonical
functions
without
DNA.
Such
role
supporting
may
exerted
RB-SKP2-p27-cyclin
A/E-CDK2-p130-DREAM
link.
current
synopsis,
mechanism
regulation
assessed
examined.
Advances in Nutrition,
Год журнала:
2023,
Номер
14(5), С. 1085 - 1110
Опубликована: Май 27, 2023
Cancer
is
one
of
the
primary
causes
death
worldwide,
and
its
incidence
continues
to
increase
yearly.
Despite
significant
advances
in
research,
search
for
effective
nontoxic
preventive
therapeutic
agents
remains
greatly
important.
a
multimodal
disease,
where
various
mechanisms
play
roles
occurrence
progression.
This
highlights
need
multitargeted
approaches
that
are
not
only
safe
inexpensive
but
also
provide
alternatives
current
regimens.
β-Sitosterol
(SIT),
most
abundant
phytosterol
found
plant
foods,
represents
such
an
option.
Preclinical
evidence
over
past
few
decades
has
overwhelmingly
shown
SIT
exhibits
multiple
anticancer
activities
against
varied
cancers,
as
liver,
cervical,
colon,
stomach,
breast,
lung,
pancreatic,
prostate
addition
leukemia,
myeloma,
melanoma,
fibrosarcoma.
In
this
article,
we
present
latest
perspectives
on
SIT-systematically
summarizing
antitumor
action
into
7
main
sections
combining
challenges
prospects-for
use
promising
agent
cancer
prevention
treatment.
particular,
plays
role
treatment
mainly
by
enhancing
apoptosis,
inducing
cell
cycle
arrest,
bidirectionally
regulating
oxidative
stress,
improving
metabolic
reprogramming,
inhibiting
invasion
metastasis,
modulating
immunity
inflammation,
combating
drug
resistance.
Although
holds
great
promise,
poor
aqueous
solubility
bioavailability
coupled
with
low
targeting
efficacy
limit
clinical
application.
Further
research
novel
delivery
systems
may
improve
these
deficiencies.
Overall,
through
complex
pleiotropic
mechanisms,
good
potential
tumor
chemoprevention
chemotherapy.
However,
no
trials
have
yet
proven
potential.
review
provides
theoretical
basis
rationality
further
design
conduct
confirm
activity
SIT.
Annual Review of Cell and Developmental Biology,
Год журнала:
2022,
Номер
38(1), С. 291 - 319
Опубликована: Май 14, 2022
The
most
fundamental
feature
of
cellular
form
is
size,
which
sets
the
scale
all
cell
biological
processes.
Growth,
form,
and
function
are
necessarily
linked
in
biology,
but
we
often
do
not
understand
underlying
molecular
mechanisms
nor
their
specific
functions.
Here,
review
progress
toward
determining
that
regulate
size
yeast,
animals,
plants,
as
well
understanding
regulation.
It
has
become
increasingly
clear
mechanism
regulation
deeply
intertwined
with
basic
biosynthesis,
how
biosynthesis
can
be
scaled
(or
not)
proportion
to
size.
Finally,
highlight
recent
findings
causally
linking
aberrant
senescence
implications
for
cancer
therapies.
Genes & Diseases,
Год журнала:
2022,
Номер
11(1), С. 218 - 233
Опубликована: Дек. 28, 2022
Ribonucleotide
reductase
M2
(RRM2)
is
a
small
subunit
in
ribonucleotide
reductases,
which
participate
nucleotide
metabolism
and
catalyze
the
conversion
of
nucleotides
to
deoxynucleotides,
maintaining
dNTP
pools
for
DNA
biosynthesis,
repair,
replication.
RRM2
performs
critical
role
malignant
biological
behaviors
cancers.
The
structure,
regulation,
function
its
inhibitors
were
discussed.
gene
can
produce
two
transcripts
encoding
same
ORF.
expression
regulated
at
multiple
levels
during
processes
from
transcription
translation.
Moreover,
this
associated
with
resistance,
cell
death,
tumor
immunity.
In
order
develop
design
RRM2,
appropriate
strategies
be
adopted
based
on
different
mechanisms.
Thus,
greater
appreciation
characteristics
benefit
understanding
tumorigenesis,
resistance
cancer,
microenvironment.
RRM2-targeted
therapy
will
more
attention
future
therapeutic
approaches
enhancement
treatment
effects
amelioration
dismal
prognosis.
